Recombinant Mouse C-terminal-binding protein 1 (Ctbp1)

中文名稱：

Recombinant Mouse C-terminal-binding protein 1(Ctbp1)
貨號：

CSB-YP006135MO
說明書：

MSDS Datasheet
規(guī)格：
來源：

Yeast
其他：

中文名稱：

Recombinant Mouse C-terminal-binding protein 1(Ctbp1)
貨號：

CSB-EP006135MO
說明書：

MSDS Datasheet
規(guī)格：
來源：

E.coli
其他：

中文名稱：

Recombinant Mouse C-terminal-binding protein 1(Ctbp1)
貨號：

CSB-EP006135MO-B
說明書：

MSDS Datasheet
規(guī)格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

Recombinant Mouse C-terminal-binding protein 1(Ctbp1)
貨號：

CSB-BP006135MO
說明書：

MSDS Datasheet
規(guī)格：
來源：

Baculovirus
其他：

中文名稱：

Recombinant Mouse C-terminal-binding protein 1(Ctbp1)
貨號：

CSB-MP006135MO
說明書：

MSDS Datasheet
規(guī)格：
來源：

Mammalian cell
其他：

產(chǎn)品詳情
產(chǎn)品評價
靶點詳情

產(chǎn)品詳情

純度：

>85% (SDS-PAGE)
基因名：

Ctbp1
Uniprot No.：

O88712
別名：

Ctbp1C-terminal-binding protein 1; CtBP1; EC 1.1.1.-
種屬：

Mus musculus (Mouse)
蛋白長度：

Full length protein
表達區(qū)域：

1-441
氨基酸序列

MGSSHLLNKG LPLGVRPPIM NGPMHPRPLV ALLDGRDCTV EMPILKDVAT VAFCDAQSTQ EIHEKVLNEA VGALMYHTIT LTREDLEKFK ALRIIVRIGS GFDNIDIKSA GDLGIAVCNV PAASVEETAD STLCHILNLY RRTTWLHQAL REGTRVQSVE QIREVASGAA RIRGETLGII GLGRVGQAVA LRAKAFGFNV LFYDPYLSDG IERALGLQRV STLQDLLFHS DCVTLHCGLN EHNHHLINDF TVKQMRQGAF LVNTARGGLV DEKALAQALK EGRIRGAALD VHESEPFSFS QGPLKDAPNL ICTPHAAWYS EQASIEMREE AAREIRRAIT GRIPDSLKNC VNKDHLTAAT HWASMDPAVV HPELNGAAYS RYPPGVVSVA PTGIPAAVEG IVPSAMSLSH GLPPVAHPPH APSPGQTVKP EADRDHTSDQ L
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產(chǎn)品提供形式：

Lyophilized powder Warning: in_array() expects parameter 2 to be array, null given in /www/web/cusabio_cn/public_html/caches/caches_template/default/content/show_product_protein.php on line 662
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質(zhì)期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產(chǎn)品評價

靶點詳情

功能：

Corepressor targeting diverse transcription regulators such as GLIS2 or BCL6. Has dehydrogenase activity. Involved in controlling the equilibrium between tubular and stacked structures in the Golgi complex. Functions in brown adipose tissue (BAT) differentiation.
基因功能參考文獻：
1. validated as novel and reliable, tissue-specific reference gene in qRT-PCR studies of postnatal mammary gland development PMID: 27752147
2. C-terminal binding protein 1 is a critical factor linking changes in cell metabolism to cell phenotype in hypoxic and other forms of pulmonary hypertension PMID: 27562971
3. CtBP1 protein is not essential for the formation of functional ribbon synapses in the retina. PMID: 23687428
4. Study demonstrates differential regional and subcellular expression patterns for CtBP1 and CtBP2 in brain and reveals a previously unknown synaptic localization for CtBP2 in particular brain regions. PMID: 22745816
5. CtBp proteins repress transcription in a histone deacetylase dependent or independent manner. PMID: 11864595
6. The leukemia-associated transcription repressor AML1/MDS1/EVI1 requires CtBP to induce abnormal growth and differentiation of murine hematopoietic cells. PMID: 12082639
7. Mice harboring various combinations of Ctbp1 and Ctbp2 mutant alleles exhibit dosage-sensitive defects in a wide range of developmental processes PMID: 12101226
8. Genetic knockout of Cbtp1 in mouse embryo fibroblasts upregulates several genes involved in apoptosis. PMID: 14567915
9. Smad6 repressed bone morphogenetic protein-induced Id1 transcription through recruiting transcriptional corepressor C-terminal binding protein (CtBP). PMID: 14645520
10. Mono-ADP-ribosylation of CtBP1/BARS inactivates its repressor function, which leads to the activation of genes that regulate neutral lipid storage. PMID: 17538025
11. p19Arf inhibits the invasion of hepatocellular carcinoma cells by binding to C-terminal binding protein. PMID: 18199542
12. basic Kruppel-like factor gene (Klf3) has a role with CtBP in adipogenesis PMID: 18391014
13. The regulated docking of the CtBP proteins on PRDM16 controls the brown and white fat-selective gene programs. PMID: 18483224
14. CtBP knockout increases Bax transcription, ablates mitochondrial morphology and reduces mitochondrial activities PMID: 19136938
15. CtBP1 expressed in human CD4(+) T cells crucially contribute to Th1/Th2 differentiation via selective down-regulation of IL-4 synthesis. PMID: 19275882
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亞細胞定位：

Cytoplasm. Nucleus.
蛋白家族：

D-isomer specific 2-hydroxyacid dehydrogenase family
組織特異性：

Expressed in a wide range of adult tissues.
數(shù)據(jù)庫鏈接：

KEGG: mmu:13016

STRING: 10090.ENSMUSP00000078682

UniGene: Mm.240076