Recombinant Mouse Breast cancer metastasis-suppressor 1 homolog (Brms1)

中文名稱：

Recombinant Mouse Breast cancer metastasis-suppressor 1 homolog(Brms1)
貨號：

CSB-YP859570MO
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

Recombinant Mouse Breast cancer metastasis-suppressor 1 homolog(Brms1)
貨號：

CSB-EP859570MO
說明書：

MSDS Datasheet
規格：
來源：

E.coli
其他：

中文名稱：

Recombinant Mouse Breast cancer metastasis-suppressor 1 homolog(Brms1)
貨號：

CSB-EP859570MO-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

Recombinant Mouse Breast cancer metastasis-suppressor 1 homolog(Brms1)
貨號：

CSB-BP859570MO
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：

Recombinant Mouse Breast cancer metastasis-suppressor 1 homolog(Brms1)
貨號：

CSB-MP859570MO
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

Brms1
Uniprot No.：

Q99N20
別名：

Brms1Breast cancer metastasis-suppressor 1 homolog
種屬：

Mus musculus (Mouse)
蛋白長度：

full length protein
表達區域：

1-246
氨基酸序列

MPIQPSGKET EEMEAEGDSA AEMNGEADES EEERSGSQTE SEEESSEMDD EDYERRRSEC VSEMLDLEKQ FSELKEKLFR ERLSQLRLRL EEVGAERAPE YTEPLGGLQQ SLKIRIQVAG IYKGFCLDVI RNKYECELQG AKQHLESEKM LLYDTLLGEL QERIQRLEED RQSLDISSEW WDDKLHSRSS SKAGDAMPPS KRKKAPLVSG PYIVYMLQEI DILEDWTAIK KARAAVSPQK RKADGP
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Transcriptional repressor. Down-regulates transcription activation by NF-kappa-B by promoting the deacetylation of RELA at 'Lys-310'. Promotes HDAC1 binding to promoter regions. Down-regulates expression of anti-apoptotic genes that are controlled by NF-kappa-B. Promotes apoptosis in cells that have inadequate adherence to a substrate, a process called anoikis, and may thereby inhibit metastasis.
基因功能參考文獻：
1. The Brms1 suppressed pulmonary metastasis and promoted apoptosis of tumor cells located in the lungs but not in the mammary glands. PMID: 22241150
2. Comparative sequence analysis in eight inbred strains PMID: 12115030
3. BRMS1 may participate in transcriptional regulation via interaction with the mSin3.HDAC complex PMID: 14581478
4. results show for the first time that BRMS1 contains both nuclear import and export signals enabling its nucleo-cytoplasmic shuttling PMID: 19649328
亞細胞定位：

Nucleus. Cytoplasm.
蛋白家族：

BRMS1 family
數據庫鏈接：

KEGG: mmu:107392

STRING: 10090.ENSMUSP00000112266

UniGene: Mm.29628