Recombinant Mouse Breast cancer anti-estrogen resistance protein 3 (Bcar3), partial

中文名稱：

Recombinant Mouse Breast cancer anti-estrogen resistance protein 3(Bcar3) ,partial
貨號：

CSB-YP879475MO
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

Recombinant Mouse Breast cancer anti-estrogen resistance protein 3(Bcar3) ,partial
貨號：

CSB-EP879475MO
說明書：

MSDS Datasheet
規格：
來源：

E.coli
其他：

中文名稱：

Recombinant Mouse Breast cancer anti-estrogen resistance protein 3(Bcar3) ,partial
貨號：

CSB-EP879475MO-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

Recombinant Mouse Breast cancer anti-estrogen resistance protein 3(Bcar3) ,partial
貨號：

CSB-BP879475MO
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：

Recombinant Mouse Breast cancer anti-estrogen resistance protein 3(Bcar3) ,partial
貨號：

CSB-MP879475MO
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

Bcar3
Uniprot No.：

Q9QZK2
別名：

Bcar3; And34Breast cancer anti-estrogen resistance protein 3 homolog; p130Cas-binding protein AND-34
種屬：

Mus musculus (Mouse)
蛋白長度：

Partial
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Acts as an adapter protein downstream of several growth factor receptors to promote cell proliferation, migration, and redistribution of actin fibers. Specifically involved in INS/insulin signaling pathway by mediating MAPK1/ERK2-MAPK3/ERK1 activation and DNA synthesis. Promotes insulin-mediated membrane ruffling. In response to vasoconstrictor peptide EDN1, involved in the activation of RAP1 downstream of PTK2B via interaction with phosphorylated BCAR1. Inhibits cell migration and invasion via regulation of TGFB-mediated matrix digestion, actin filament rearrangement, and inhibition of invadopodia activity. May inhibit TGFB-SMAD signaling, via facilitating BCAR1 and SMAD2 and/or SMAD3 interaction. Regulates EGF-induced DNA synthesis. Required for the maintenance of ocular lens morphology and structural integrity, potentially via regulation of focal adhesion complex signaling. Acts upstream of PTPRA to regulate the localization of BCAR1 and PTPRA to focal adhesions, via regulation of SRC-mediated phosphorylation of PTPRA. Positively regulates integrin-induced tyrosine phosphorylation of BCAR1. Acts as a guanine nucleotide exchange factor (GEF) for small GTPases RALA, RAP1A and RRAS. However, in a contrasting study, lacks GEF activity towards RAP1.
基因功能參考文獻：
1. The first spontaneous mutation in the Bcar3 gene associated with lens extrusion cataracts. PMID: 27364350
2. data presented here suggest that Bcar3 could play a role in testis development PMID: 21654156
3. many BCAR3-mediated signaling events in epithelial and mesenchymal cells are independent of p130Cas association PMID: 21262352
4. p130Cas- and HEF1-associated AND-34 may regulate B cell adhesion and motility through a Cdc42-mediated signaling pathway. PMID: 12517963
5. study presents a pluridisciplinary approach, including small-angle X-ray scattering, that provides first insights into the structure of the complex formed between BCAR3 and human enhancer of filamentation 1 (HEF1) PMID: 19103205
6. AND-34-mediated signaling is required for maintenance of the structural integrity of the adult ocular lens. PMID: 19365570
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亞細胞定位：

Cytoplasm. Cell junction, focal adhesion.
組織特異性：

Abundantly expressed in the lung and brain, with lower expression in splenic lymphocytes and liver (at protein level). Expressed in splenic lymphocytes (at protein level). Expressed in the lymph node cortical region, periphery of the splenic white pulp an
數據庫鏈接：

KEGG: mmu:29815

STRING: 10090.ENSMUSP00000029766

UniGene: Mm.398478