Recombinant Mouse Bile salt export pump (Abcb11), partial

中文名稱：

Recombinant Mouse Bile salt export pump(Abcb11) ,partial
貨號：

CSB-YP882557MO
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

Recombinant Mouse Bile salt export pump(Abcb11) ,partial
貨號：

CSB-EP882557MO
說明書：

MSDS Datasheet
規格：
來源：

E.coli
其他：

中文名稱：

Recombinant Mouse Bile salt export pump(Abcb11) ,partial
貨號：

CSB-EP882557MO-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

Recombinant Mouse Bile salt export pump(Abcb11) ,partial
貨號：

CSB-BP882557MO
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：

Recombinant Mouse Bile salt export pump(Abcb11) ,partial
貨號：

CSB-MP882557MO
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

Abcb11
Uniprot No.：

Q9QY30
別名：

Abcb11; Bsep; SpgpBile salt export pump; EC 7.6.2.-; ATP-binding cassette sub-family B member 11; Sister of P-glycoprotein
種屬：

Mus musculus (Mouse)
蛋白長度：

Partial
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Catalyzes the transport of the major hydrophobic bile salts, such as taurine and glycine-conjugated cholic acid across the canalicular membrane of hepatocytes in an ATP-dependent manner, therefore participates in hepatic bile acid homeostasis and consequently to lipid homeostasis through regulation of biliary lipid secretion in a bile salts dependent manner. Transports taurine-conjugated bile salts more rapidly than glycine-conjugated bile salts. Also transports non-bile acid compounds, such as pravastatin and fexofenadine in an ATP-dependent manner and may be involved in their biliary excretion.
基因功能參考文獻：
1. Studied effect of endotoxin exposure on liver following partial hepatectomy; found endotoxin exposure induced autoantibody production against Bsep (bile salt export pump) leading to dysfunction of hepatobiliary transporter systems. PMID: 29850541
2. mechanism of increased biliary lipid secretion in Bsep-/- mice is based on increased expression of the responsible canalicular transporter proteins. PMID: 25552583
3. expression repressed by estradiol in the late stages of pregnancy PMID: 24729004
4. CA feeding of Bsep (-/-) mice increased hepatic Cyp3a11 protein levels. PMID: 24399466
5. FXR regulates BSEP in an isoform-dependent and species-specific manner PMID: 24002920
6. Ursodeoxycholic acid fed to abcb11-/- mice caused liver damage and the appearance of biliary tetra- and penta-hydroxy bile acids. PMID: 23764895
7. Hepatic Abcb11 overexpression in mice increases the conservation of bile acids within the enterohepatic circulation. PMID: 23139217
8. The authors show that two of these transporters, ABCB11 and ATP8B1, are functional targets of miR-33, a micro-RNA that is expressed from within an intron of SREBP-2. PMID: 22767443
9. Abcb11 deficiency induces cholestasis coupled to impaired beta-fatty acid oxidation in mice. PMID: 22619174
10. hyperosmotic cholestasis is triggered by a NADPH oxidase-driven reactive oxygen species formation that mediates Fyn-dependent retrieval of the Mrp2 and Bsep from the canalicular membrane, which may involve an increased cortactin phosphorylation. PMID: 22057277
11. Hepatic overexpression of Abcb11 in mice promotes diet-induced obesity and hypercholesterolemia; increased intestinal cholesterol absorption by hydrophobic bile acids might cause these features. PMID: 21726512
12. bile salt export pump (BSEP) PMID: 21195347
13. Atypical 3 alpha,6 beta,7 beta,12 alpha-tetrahydroxy-5 beta-cholan-24-oic acid appears in spgp knockout mice PMID: 12562825
14. regulation of Abcb11 may be important for the pathogenesis and treatment of steatohepatitis PMID: 14570929
15. the effect of the D482G progressive familial intrahepatic cholestasis type 2 related mutation on BSEP function PMID: 14672610
16. We conclude that gallstone-susceptible C57L/J mice demonstrate increased gene and canalicular membrane expression of Abcb11, however, taurocholate transport is functionally diminished. PMID: 14724752
17. Elevated level of Mdr1 in Abcb11 knockout mice functions as an alternative pathway to transport bile acids PMID: 16156672
18. Hepatic overexpression of Abcb11 increases the rate of cholesterol gallstone formation,likely due to increases in bile salt hydrophobicity but not because of alterations of other biliary lipid transporters. This strongly support Abcb11 as a Lith 1 gene. PMID: 16341669
19. Hepatic expression of BSEP mRNA decreased after transplantation. PMID: 18551070
20. In the liver, histone H3 in the proximal promoter of Bsep is hyperacetylated, whereas acetylation in the kidney and cerebrum is minimal. PMID: 19047482
21. membrane cholesterol content is a critical determinant of ABCB11/ABCC2 transport activity, which might provide an explanation for the etiology of ATP8B1 disease PMID: 19228692
22. Report Role of hepatic Bsep transporter in prevention of bile acid toxicity after partial hepatectomy in mice. PMID: 19497955
23. triple knockout mouse (Mdr1a & Mdr1b &BSEP) is the most severe genetic model of intrahepatic cholestasis yet developed. P-glycoprotein functions as a critical compensatory mechanism, which reduces the severity of cholestasis in Bsep knockout mice. PMID: 19650158
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亞細胞定位：

Apical cell membrane; Multi-pass membrane protein. Recycling endosome membrane; Multi-pass membrane protein. Endosome. Cell membrane; Multi-pass membrane protein.
蛋白家族：

ABC transporter superfamily, ABCB family, Multidrug resistance exporter (TC 3.A.1.201) subfamily
組織特異性：

Expressed predominantly, if not exclusively in the liver, where it was further localized to the canalicular microvilli and to subcanalicular vesicles of the hepatocytes by in situ.
數據庫鏈接：

KEGG: mmu:27413

STRING: 10090.ENSMUSP00000099770

UniGene: Mm.439855