1. BATF plays a key role in the differentiation of T helper cell subsets and Ig class-switching. Apart from that we suggest an important function in mast cell development and in murine models of allergic asthma, it was observed that mice deficient for Batf are protected from the disease. Hence, the previous findings on BATF make it an interesting target for the treatment of Th cell-derived-cytokine-driven diseases. PMID: 26970726
2. repressed BATF expression contributes to impaired Treg functions caused by A384T mutation in Foxp3 PMID: 28778586
3. these findings reveal BATF as a central modulator of peripheral and humoral hallmarks of type-2 immunity and begin to elucidate a novel mechanism by which it regulates type-2 cytokine production through its modification of the Th2 locus control region. PMID: 27798167
4. Our studies uncovered the critical role of two transcription factors, IRF1 and BATF, in preparing the chromatin landscape for induction of the Tr1 gene network in response to IL-27 signaling, where BATF acted as a pioneer factor and prepared the genomic landscape for the binding of additional transcription factors that define the Tr1 lineage. PMID: 28166218
5. BATF/JUN-B and BATF/C-JUN complexes play important roles in OA cartilage destruction through regulating anabolic and catabolic gene expression in chondrocytes. PMID: 27147707
6. this study shows that the affinity of different enhancers for the BATF-IRF4 complex might underlie divergent signaling outcomes in response to various strengths of TCR signaling PMID: 28346410
7. BATF overexpression sufficiently rescues "unhelped" CD8 T cells. BATF and IRF4 cooperatively regulate Blimp-1 expression and effector T cell function . PMID: 26527008
8. These results indicate a positive role of Batf in promoting the generation of pro-allergic IL-4-producing T-follicular helper cells. PMID: 26278622
9. The transcription factors IRF4 and BATF are major regulators of antiviral cytotoxic T-cell immunity. PMID: 24531538
10. BATF is essential for initial commitment of naive T8 cells to effector development but becomes dispensable by 72h. This makes possible a study of gene function in vivo in unperturbed cells of hematopoietic origin that are refractory to viral transduction. PMID: 25548173
11. amplifies CD8+ T cell TCR-dependent expression of transcription factors and inflammatory signals but restrains the expression of effector molecules PMID: 24584090
12. knock-out mice have reduced pathophysiologic signs of asthma, decreased IL-3 production and mast cells development PMID: 24290279
13. The activator protein 1 (AP1) family transcription factor BATF (B cell, activating transcription factor-like) was among the genes enriched in Th9 cells and was required for the expression of IL-9 and other Th9-associated genes. PMID: 24216482
14. BATF joins RORgammat as the molecular signature for all IL-17 producing cells in vivo. PMID: 23537103
15. A previously unknown function of early growth response gene (Egr)-2 in the control of T helper (Th)17 cytokine expression and Th17 differentiation by inhibition of Batf function. PMID: 23203924
16. BATF-JUN family protein complexes cooperate with IRF4 in binding to AP1-IRF composite elements in pre-activated CD4( ) T cells stimulated with IL-21 and in T(H)17 differentiated cells PMID: 22992523
17. Compensation among BATF factors is based on the shared capacity of their leucine zipper domains to interact with non-AP1 factors such as IRF4 and IRF8 to mediate cooperative gene activation. PMID: 22992524
18. BATF, together with c-Jun, transcriptionally inhibited expression of the nicotinamide adenine dinucleotide (NAD(+))-dependent deacetylase Sirt1 PMID: 21873234
19. Data show that BATF functions at multiple hierarchical levels in two cell types to globally regulate switched antibody responses in vivo. PMID: 21572431
20. Batf mediates the differentiation-inducing effects of Stat3 signaling in M1 cells and suggest that Batf may play a similar role in other blood cell lineages where alterations to the Jak-Stat pathway are hallmarks of disrupted development and disease. PMID: 21296860
21. PD-1 inhibits T cell function by upregulating BATF. PMID: 20890291
22. Loss of Batf disrupts multiple components of the lymphocyte communication network that are required for a robust immune response. PMID: 20421391
23. This study revealed that older BAFF transgenic mice exhibit an anxiety-like phenotype associated with brain inflammation. PMID: 20185032
24. Stat3 mediates cellular growth by modulating AP-1 activity through the induction of BATF PMID: 12444555
25. Fos/Jdp2/Batf locus is associated with SL3-3 mouse leukemia virus B cell lymphoma. PMID: 15913695
26. results demonstrate that the AP-1 protein BATF has a critical role in T(H)17 differentiation PMID: 19578362

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KEGG: mmu:53314

STRING: 10090.ENSMUSP00000040706

UniGene: Mm.6672