Recombinant Mouse Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2 (Agap2), partial

中文名稱：

Recombinant Mouse Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2(Agap2) ,partial
貨號：

CSB-YP666260MO
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

Recombinant Mouse Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2(Agap2) ,partial
貨號：

CSB-EP666260MO
說明書：

MSDS Datasheet
規格：
來源：

E.coli
其他：

中文名稱：

Recombinant Mouse Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2(Agap2) ,partial
貨號：

CSB-EP666260MO-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

Recombinant Mouse Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2(Agap2) ,partial
貨號：

CSB-BP666260MO
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：

Recombinant Mouse Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2(Agap2) ,partial
貨號：

CSB-MP666260MO
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

Agap2
Uniprot No.：

Q3UHD9
別名：

Agap2; Centg1; Kiaa0167Arf-GAP with GTPase; ANK repeat and PH domain-containing protein 2; AGAP-2; Centaurin-gamma-1; Cnt-g1; Phosphatidylinositol 3-kinase enhancer; PIKE
種屬：

Mus musculus (Mouse)
蛋白長度：

Partial
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

GTPase-activating protein (GAP) for ARF1 and ARF5, which also shows strong GTPase activity. Participates in the prevention of neuronal apoptosis by enhancing PI3 kinase activity. Aids the coupling of metabotropic glutamate receptor 1 (GRM1) to cytoplasmic PI3 kinase by interacting with Homer scaffolding proteins, and also seems to mediate anti-apoptotic effects of NGF by activating nuclear PI3 kinase.
基因功能參考文獻：
1. Dopamine and DOPAC were not changed in 3-mo-old mice but were decreased at 8 mo in the striatum of PIKE-KO mice compared with wild-type mice. DA and DOPAC in hippocampus and substantia nigra were significantly decreased in 3-mo-old and 8-mo-old PIKE-KO mice as compared with wild-type mice. More severe motor defects in PIKE-KO and Fyn-KO mice than in wild-type mice exposed to alpha synuclein and MPTP. PMID: 28096359
2. Depletion of PIKE-A in C2C12 myotubes diminished the inhibitory activities of TNF-alpha on mitochondrial respiration and lipid oxidation, whereas PIKE-A overexpression exacerbated these cellular responses. PMID: 28404596
3. PIKE plays pivotal roles to advance oligodendroglia development and myelinogenesis through Akt/mTOR activation. PMID: 24449917
4. Results demonstrate that the integrity of PIKE signaling is essential for protecting the neurons from excitotoxicity-stimulated damage both in vitro and in vivo. PMID: 21925531
5. Fyn regulates the activity of the adipogenic transcription factor signal transducer and activator of transcription 5a (STAT5a) through enhancing its interaction with the GTPase phosphoinositide 3-kinase enhancer A (PIKE-A). PMID: 23438599
6. PIKE is a critical factor in controlling synaptic AMPA receptor insertion. PMID: 21847098
7. data established the critical role of PIKE in regulating neuronal survival and development by substantiating the PI3K/Akt pathway. PMID: 21632930
8. PIKE-A is required for prolactin-mediated STAT5a activation in mammary gland development. PMID: 20075866
9. PIKE knockout mice show augmented lipid oxidation, which is accompanied by enhanced AMPK phosphorylation in muscle and adipose tissue and is implicated in obesity and diabetes development. PMID: 20068140
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亞細胞定位：

Cytoplasm. Nucleus.
蛋白家族：

Centaurin gamma-like family
數據庫鏈接：

KEGG: mmu:216439

STRING: 10090.ENSMUSP00000043466

UniGene: Mm.336761