Recombinant Mouse Apoptosis regulatory protein Siva (Siva1)

中文名稱：

小鼠Siva1重組蛋白
貨號：

CSB-YP021347MO
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

小鼠Siva1重組蛋白
貨號：

CSB-EP021347MO
說明書：

MSDS Datasheet
規格：
來源：

E.coli
其他：

中文名稱：

小鼠Siva1重組蛋白
貨號：

CSB-EP021347MO-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

小鼠Siva1重組蛋白
貨號：

CSB-BP021347MO
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：

小鼠Siva1重組蛋白
貨號：

CSB-MP021347MO
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

Siva1
Uniprot No.：

O54926
別名：

Siva1; Siva; Apoptosis regulatory protein Siva; CD27-binding protein; CD27BP
種屬：

Mus musculus (Mouse)
蛋白長度：

Full length protein
表達區域：

1-175
氨基酸序列

MPKRSCPFAD AAPLQLKVHV GLKELSHGVF AERYSREVFE RTKQLLFQGA RAYRDHISSE DCSVNHLQES LKSGVVGAPQ PARGQMLIGP DGRLTRCQAQ ASEGGLPRTA PIACSSCMRS VDGKAVCSQC ERALCGQCVY TCWGCGALAC VLCGLADYAD DGEKTLCTSC AMFEA
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Induces CD27-mediated apoptosis. Inhibits BCL2L1 isoform Bcl-x(L) anti-apoptotic activity. Inhibits activation of NF-kappa-B and promotes T-cell receptor-mediated apoptosis.
基因功能參考文獻：
1. SIVA is a direct transcriptional target for the tumor suppressors p53 and E2F1 PMID: 15105421
2. Siva's expression pattern suggests that it plays an instructive role in apoptosis, and accordingly, we demonstrate that Siva is essential for p53-dependent apoptosis in cerebellar granule neurons. PMID: 17464332
3. lysophosphatidic acid 2 receptor mediates down-regulation of Siva-1 to promote cell survival PMID: 17965021
4. Data show that SLIMMER delayed Siva-1-dependent apoptosis in C2C12 myoblasts. PMID: 19643733
亞細胞定位：

Cytoplasm. Nucleus.
組織特異性：

Highly expressed in testis, heart, liver, lung, and muscle, and less in kidney, spleen and brain.
數據庫鏈接：

KEGG: mmu:30954

STRING: 10090.ENSMUSP00000021728

UniGene: Mm.289812