Recombinant Mouse Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase (St8sia1), partial

中文名稱：

小鼠St8sia1重組蛋白
貨號：

CSB-YP734123MO
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

小鼠St8sia1重組蛋白
貨號：

CSB-EP734123MO
說明書：

MSDS Datasheet
規格：
來源：

E.coli
其他：

中文名稱：

小鼠St8sia1重組蛋白
貨號：

CSB-EP734123MO-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

小鼠St8sia1重組蛋白
貨號：

CSB-BP734123MO
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：

小鼠St8sia1重組蛋白
貨號：

CSB-MP734123MO
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

St8sia1
Uniprot No.：

Q64687
別名：

St8sia1; Siat8; Siat8a; Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase; EC 2.4.99.8; Alpha-2,8-sialyltransferase 8A; Ganglioside GD3 synthase; Ganglioside GT3 synthase; Sialyltransferase 8A; SIAT8-A; Sialyltransferase St8Sia I; ST8SiaI
種屬：

Mus musculus (Mouse)
蛋白長度：

Partial
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Catalyzes the addition of sialic acid in alpha 2,8-linkage to the sialic acid moiety of the ganglioside GM3 to form ganglioside GD3; gangliosides are a subfamily of complex glycosphinglolipds that contain one or more residues of sialic acid. Can catalyze the addition of a second alpha-2,8- sialic acid to GD3 to form GT3. Can use GM1b, GD1a and GT1b as acceptor substrates to synthesize GD1c, GT1a and GQ1b respectively.
基因功能參考文獻：
1. Targeted deletion of GD3S protects substantia nigra degeneration and prevents motor deficits associated with MPTP-poisoning. PMID: 28239983
2. leptin/ObRb-mediated signals were enhanced in hypothalamus of GD3S KO mice due to increased a-series gangliosides, leading to the apparently similar features of energy expenditure between the KO and wild type mice PMID: 27644882
3. role of GD3 synthase in sciatic nerve and neuronal morphology during peripheral nerve regeneration PMID: 25330147
4. This study demonistrated that Ganglioside deficiency(B4galnt1 and ST8SIA1 knockout mice causes inflammation and neurodegeneration via the activation of complement system in the spinal cord. PMID: 24673754
5. Interaction of ganglioside GD3 with an EGF receptor sustains the self-renewal ability of mouse neural stem cells in vitro. PMID: 24198336
6. The results of this study indicated that destruction of glycolipid-enriched microdomain is caused by ganglioside deficiency with gradual intensity depending on the degree of defects of their compositions. PMID: 21214571
7. This study showed that NMJs of old mice lacking GD3-synthase (expressing only O- and a-series gangliosides), which do not show an overt neurological phenotype but may develop subclinical synaptic deficits PMID: 19233512
8. GD3 has a role in hypoxia susceptibility by disabling the c-Src/NF-kappaB survival pathway resulting in lower Mn-SOD expression PMID: 19956670
9. Molecular cloning and expression and sialylation of O-glycans PMID: 11980897
10. alpha2,8-sialyltransferase has roles in cell proliferation and mobility PMID: 15645117
11. The results of this study indicate that synaptic transmission at the NMJ is not crucially dependent on the particular presence of most ganglioside family members. PMID: 18801416
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亞細胞定位：

Golgi apparatus membrane; Single-pass type II membrane protein.
蛋白家族：

Glycosyltransferase 29 family
數據庫鏈接：

KEGG: mmu:20449

STRING: 10090.ENSMUSP00000032421

UniGene: Mm.260838