Recombinant Mouse Afadin- and alpha-actinin-binding protein (Ssx2ip)

中文名稱：

小鼠Ssx2ip重組蛋白
貨號：

CSB-YP823729MO
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

小鼠Ssx2ip重組蛋白
貨號：

CSB-EP823729MO
說明書：

MSDS Datasheet
規格：
來源：

E.coli
其他：

中文名稱：

小鼠Ssx2ip重組蛋白
貨號：

CSB-EP823729MO-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

小鼠Ssx2ip重組蛋白
貨號：

CSB-BP823729MO
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：

小鼠Ssx2ip重組蛋白
貨號：

CSB-MP823729MO
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

Ssx2ip
Uniprot No.：

Q8VC66
別名：

Ssx2ipAfadin- and alpha-actinin-binding protein; ADIP; Afadin DIL domain-interacting protein
種屬：

Mus musculus (Mouse)
蛋白長度：

full length protein
表達區域：

1-615
氨基酸序列

MGDWMTVTDP VLCTENKNLS QYTSETKMSP SSLYSQQVLC SSVPLSKNVH GVFGVFCTGE NIEQSISYLD QELTTFGFPS LYEESKSKEA KRELNIVAVL NCMNELLVLQ RKNLLAQESV ETQNLKLGSD MDHLQSCYAK LKEQLETSRR EMIGLQERDR QLQCKNRSLH QLLKNEKDEV QKLQNIIASR ATQYNHDVKR KEREYNKLKE RLHQLVMNKK DKNIAMDVLN YVGRADGKRG SWRTDKTEAR NEDEMYKILL NDYEYRQKQI LMENAELKKV LQQMKKEMIS LLSPQKKKPR ERAEDGTGTV AISDIEDDSG ELSRDSVWGL SCDTVREQLT NSIRKQWRIL KSHVEKLDNQ ASKVHSEGLN EEDVISRQDH EQETEKLELE IERCKEMIKA QQQLLQQQLA TTCDDDTTSL LRDCYLLEEK ERLKEEWTLF KEQKKNFERE RRSFTEAAIR LGLERKAFEE ERASWVKQQF LNMTNFDHQN SENVKLFSAF SGSSDPDNLI VHSRPRQKKL HSVANGVPAC TSKLTKSLPA SPSTSDFRQT HSCVSEHSSI SVLNITPEES KPSEVAREST DQKWSVQSRP SSREGCYSGC SSAFRSAHGD RDDLP
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Belongs to an adhesion system, which plays a role in the organization of homotypic, interneuronal and heterotypic cell-cell adherens junctions (AJs). May connect the nectin-afadin and E-cadherin-catenin system through alpha-actinin and may be involved in organization of the actin cytoskeleton at AJs through afadin and alpha-actinin. Acts as a centrosome maturation factor, probably by maintaining the integrity of the pericentriolar material and proper microtubule nucleation at mitotic spindle poles. The function seems to implicate at least in part WRAP73; the SSX2IP:WRAP73 complex is proposed to act as regulator of spindle anchoring at the mitotic centrosome. Involved in cell movement: localizes at the leading edge of moving cells in response to PDGF and is required for the formation of the leading edge and the promotion of cell movement, possibly via activation of Rac signaling. Involved in ciliogenesis. It is required for targeted recruitment of the BBSome, CEP290, RAB8, and SSTR3 to the cilia.
基因功能參考文獻：
1. The novel centriolar satellite protein SSX2IP targets Cep290 to the ciliary transition zone. PMID: 24356449
2. The results indicate that ADIP plays an essential role in PDGF-induced cell movement by interacting with afadin and Vav2 and regulating the activation of Rac. PMID: 22027834
3. localization at cell-cell adherens junctions PMID: 12446711
亞細胞定位：

Cell junction, adherens junction. Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite. Cytoplasm, cytoskeleton, cilium basal body. Note=Not found at cell-matrix AJs.
蛋白家族：

ADIP family
組織特異性：

Widely expressed.
數據庫鏈接：

KEGG: mmu:99167

STRING: 10090.ENSMUSP00000101759

UniGene: Mm.200783