Recombinant Mouse ATP-citrate synthase (Acly), partial

中文名稱：

Recombinant Mouse ATP-citrate synthase(Acly) ,partial
貨號：

CSB-YP820984MO
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

Recombinant Mouse ATP-citrate synthase(Acly) ,partial
貨號：

CSB-EP820984MO
說明書：

MSDS Datasheet
規格：
來源：

E.coli
其他：

中文名稱：

Recombinant Mouse ATP-citrate synthase(Acly) ,partial
貨號：

CSB-EP820984MO-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

Recombinant Mouse ATP-citrate synthase(Acly) ,partial
貨號：

CSB-BP820984MO
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：

Recombinant Mouse ATP-citrate synthase(Acly) ,partial
貨號：

CSB-MP820984MO
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

Acly
Uniprot No.：

Q91V92
別名：

AclyATP-citrate synthase; EC 2.3.3.8; ATP-citrate; pro-S-)-lyase; Citrate cleavage enzyme
種屬：

Mus musculus (Mouse)
蛋白長度：

Partial
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis.
基因功能參考文獻：
1. ACL regulates the net amount of acetyl groups available, leading to alterations in acetylation of H3(K9/14) and H3(K27) at the MYOD locus, thus increasing MYOD expression. PMID: 29241530
2. We propose that D2-HG promotes cardiac dysfunction by impairing alpha-ketoglutarate dehydrogenase and induces histone modifications in an ACL-dependent manner PMID: 27582470
3. these data indicate that engagement of acetate metabolism is a crucial, although partial, mechanism of compensation for ACLY deficiency. PMID: 27760311
4. ACL plays a critical role in epigenetic regulation of diabetic renal fibrosis. PMID: 28490526
5. ATP-citrate lyase inhibitor bempedoic acid effectively prevents plasma and tissue lipid elevations and attenuates the onset of inflammation, leading to the prevention of atherosclerotic lesion development in a Ldlr knockout mouse model of metabolic dysregulation. PMID: 28153881
6. IL-4 signaling co-opts the Akt-mTORC1 pathway to regulate Acly, a key enzyme in acetyl-CoA synthesis, leading to increased histone acetylation and macrophage gene induction. PMID: 26894960
7. These data demonstrate that ACLY mediates glucose-dependent de novo lipogenesis in response to LPS signaling and identify a role for ACLY in several phenotypic changes that define plasma cell differentiation PMID: 24469453
8. Results suggest a role for DNA methyltransferase 1 (DNMT1) in modulating the timing of differentiation and describe a novel ATP-citrate lyase (ACL)-miR-148a-dependent mechanism for regulating DNMT1 during adipogenesis. PMID: 23897429
9. Differences between human and rodent pancreatic islets: low pyruvate carboxylase, atp citrate lyase, and pyruvate carboxylation and high glucose-stimulated acetoacetate in human pancreatic islets. PMID: 21454710
10. Results demonstrate that hepatic ATP-citrate lyase suppression exerts profound effects on triglyceride mobilization as well as fatty acid compositions in the liver, suggesting an important role for ACL in lipid metabolism. PMID: 20488800
11. Data suggest that ATP-citrate lyase (ACLY) expression and activity can be suppressed by exogenous lipids and demonstrate a critical role for ACLY in pancreatic beta cell survival. PMID: 20693577
12. crucial role of hepatic ATP-citrate lyase in lipid and glucose metabolism PMID: 19177596
13. findings suggest that ATP-citrate lyase activity is required to link growth factor-induced increases in nutrient metabolism to the regulation of histone acetylation and gene expression PMID: 19461003
顯示更多

收起更多
亞細胞定位：

Cytoplasm, cytosol.
蛋白家族：

Succinate/malate CoA ligase beta subunit family; Succinate/malate CoA ligase alpha subunit family
數據庫鏈接：

KEGG: mmu:104112

STRING: 10090.ENSMUSP00000103012

UniGene: Mm.282039