Recombinant Mouse A-kinase-interacting protein 1 (Akip1)

中文名稱：

Recombinant Mouse A-kinase-interacting protein 1(Akip1)
貨號(hào)：

CSB-YP862384MO
說明書：

MSDS Datasheet
規(guī)格：
來源：

Yeast
其他：

中文名稱：

Recombinant Mouse A-kinase-interacting protein 1(Akip1)
貨號(hào)：

CSB-EP862384MO
說明書：

MSDS Datasheet
規(guī)格：
來源：

E.coli
其他：

中文名稱：

Recombinant Mouse A-kinase-interacting protein 1(Akip1)
貨號(hào)：

CSB-EP862384MO-B
說明書：

MSDS Datasheet
規(guī)格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

Recombinant Mouse A-kinase-interacting protein 1(Akip1)
貨號(hào)：

CSB-BP862384MO
說明書：

MSDS Datasheet
規(guī)格：
來源：

Baculovirus
其他：

中文名稱：

Recombinant Mouse A-kinase-interacting protein 1(Akip1)
貨號(hào)：

CSB-MP862384MO
說明書：

MSDS Datasheet
規(guī)格：
來源：

Mammalian cell
其他：

產(chǎn)品詳情
產(chǎn)品評(píng)價(jià)
靶點(diǎn)詳情

產(chǎn)品詳情

純度：

>85% (SDS-PAGE)
基因名：

Akip1
Uniprot No.：

Q9JJR5
別名：

Akip1; Bca3; A-kinase-interacting protein 1; Breast cancer-associated gene 3 protein; PKA-interacting protein; Proline-rich protein BCA3
種屬：

Mus musculus (Mouse)
蛋白長(zhǎng)度：

full length protein
表達(dá)區(qū)域：

1-212
氨基酸序列

MEYCLAAAAL NGVDRRSLQR SARLGREVLE RAKRRAVDWH SPERSRGNVG VLYRQGPYQE RWSVPGSQRL LGEREERCPT LSSSFGAMAE FMDYTSSQCG KYYLSMPEEG GATHVYRYHR RKPPEMHMYS DTGHSQEQRN CRGETSVGQE SIYQTSEHSQ ESSWPTENIS KDLYIEVYPG TYSVTVGSSA LSKKTHVVAV DPGQSVDLVF PV
蛋白標(biāo)簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產(chǎn)品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復(fù)溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲(chǔ)存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質(zhì)期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項(xiàng)：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

功能：

Enhances NF-kappa-B transcriptional activity by regulating the nuclear localization of the NF-kappa-B subunit RELA and promoting the phosphorylation of RELA by PRKACA. Regulates the effect of the cAMP-dependent protein kinase signaling pathway on the NF-kappa-B activation cascade.
基因功能參考文獻(xiàn)：
1. miR-320 plays an important role in regulating cardiomyocyte apoptosis induced by ischemia-reperfusion injury by targeting AKIP1 and inducing the mitochondrial apoptotic pathway. PMID: 30181740
2. BCA3 interacts with Rac1 and augments NF-kappaB signaling in vitro, but has no effect on RANKL-induced bone resorption in vivo. PMID: 28791343
3. AKIP1 overexpression does not influence cardiac remodelling in response to chronic cardiac stress, or heart failure development. AKIP1 does, however, reduce myocardial I/R injury through stabilization of the MPT pore. PMID: 27302402
4. Data indicate A-kinase interacting protein 1 (AKIP1) as a critical molecular regulator and a therapeutic control point for stress adaptation in the heart. PMID: 23319652
亞細(xì)胞定位：

Nucleus.
數(shù)據(jù)庫鏈接：

KEGG: mmu:57373

STRING: 10090.ENSMUSP00000033335

UniGene: Mm.334138