Recombinant Mouse A-kinase anchor protein 12 (Akap12), partial

中文名稱：

Recombinant Mouse A-kinase anchor protein 12(Akap12) ,partial
貨號：

CSB-YP896230MO
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

Recombinant Mouse A-kinase anchor protein 12(Akap12) ,partial
貨號：

CSB-EP896230MO
說明書：

MSDS Datasheet
規格：
來源：

E.coli
其他：

中文名稱：

Recombinant Mouse A-kinase anchor protein 12(Akap12) ,partial
貨號：

CSB-EP896230MO-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

Recombinant Mouse A-kinase anchor protein 12(Akap12) ,partial
貨號：

CSB-BP896230MO
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：

Recombinant Mouse A-kinase anchor protein 12(Akap12) ,partial
貨號：

CSB-MP896230MO
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

Akap12
Uniprot No.：

Q9WTQ5
別名：

Akap12; Gag12; Ssecks; A-kinase anchor protein 12; AKAP-12; Germ cell lineage protein gercelin; Src-suppressed C kinase substrate; SSeCKS
種屬：

Mus musculus (Mouse)
蛋白長度：

Partial
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Anchoring protein that mediates the subcellular compartmentation of protein kinase A (PKA) and protein kinase C (PKC).
基因功能參考文獻：
1. fibrosis induced by Ang II may be alleviated by AKAP12 expression through inactivation of the TGF-beta1 pathway. PMID: 29501491
2. gravin is an important component of cardiac contraction PMID: 28428008
3. The enrichment of activated Cdc42 in SSeCKS-null leading edge filopodia correlated with recruitment of the Cdc42-specific guanine nucleotide exchange factor, Frabin. PMID: 25356636
4. AKAP12 scaffolding protein mediates meningeal reconstruction after central nervous system injury PMID: 25229625
5. Results suggest that AKAP12-positive cells in the fibrotic scar may restrict excessive inflammation, demonstrating mechanisms that could underlie the beneficial actions of the fibrotic scar in the new tissue formation stage during the CNS repair process. PMID: 24760034
6. Disruption of gravin's scaffold mediated signaling is able to increase baseline cardiac function as well as to augment contractility in response to acute beta-AR stimulation. PMID: 24058627
7. We conclude that gravin compartmentalizes a significant pool of PKA that regulates learning-induced beta2-adrenergic receptor signaling and ERK activation in the hippocampus PMID: 23238728
8. Our study implicates a role for SSeCKS in preventing of skin cancer progression possibly through negatively regulating FAK expression. PMID: 21128249
9. controls the localization and activity of cyclin D1 in parietal epithelial cells and influences proliferative injury in the glomerulus PMID: 22249313
10. PKC-mediated remodeling of the actin cytoskeleton is likely regulated by the ability of SSeCKS to control PKC signaling and activity through a direct scaffolding function PMID: 21903576
11. Akap12 controls Rb-mediated cell aging and oncogenic progression by directly scaffolding and attenuating PKCalpha/delta. PMID: 21099353
12. SERPINB5 and AKAP12 may have a role in increased metastasis in pancreatic ductal adenocarcinoma PMID: 20939879
13. induced in vascular endothelial cells by bacterial lipopolysaccharide PMID: 11799143
14. SSeCKS has a restricted distribution within the nervous system and that expression of this protein may reflect the specific signaling requirements of a distinct population of nociceptive sensory neurons. PMID: 11814414
15. Phosphorylation of SSeCKS by mitogenically activated kinases decreases intrinsic cell scaffolding activities and suggests that SSeCKS regulatory functions are lost in the late G1 phase. PMID: 11820772
16. a role for SSeCKS in mitogen-induced cytoskeletal reorganization. PMID: 12083796
17. SSeCKS expression in endothelial cells and reticular cells is a functional index of the reticulo-endothelial system PMID: 15468953
18. alternately targeted anchoring protein isoforms provide a mechanism for genetic control of signaling specificity by AKAP12 PMID: 15496411
19. AKAP12alpha belongs to a novel class of atypical SRF-dependent target genes PMID: 15590635
20. v-Src-mediated down-regulation of SSeCKS metastasis suppressor gene promoter by the recruitment of HDAC1 into a USF1-Sp1-Sp3 complex. PMID: 17626016
21. SSeCKS-null mice have increased susceptibility for oncogenic transformation in the prostate. PMID: 18593908
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亞細胞定位：

Cytoplasm, cytoskeleton. Membrane; Lipid-anchor.
組織特異性：

Isoform 1 is predominantly found in the nervous system. Isoform 3 is testis specific.
數據庫鏈接：

KEGG: mmu:83397

STRING: 10090.ENSMUSP00000035829

UniGene: Mm.27481