Recombinant Human adenovirus A serotype 12 E1B protein, large T-antigen

中文名稱：

Recombinant Human adenovirus A serotype 12 E1B protein, large T-antigen
貨號：

CSB-YP361278HIB
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

Recombinant Human adenovirus A serotype 12 E1B protein, large T-antigen
貨號：

CSB-EP361278HIB
說明書：

MSDS Datasheet
規格：
來源：

E.coli
其他：

中文名稱：

Recombinant Human adenovirus A serotype 12 E1B protein, large T-antigen
貨號：

CSB-EP361278HIB-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

Recombinant Human adenovirus A serotype 12 E1B protein, large T-antigen
貨號：

CSB-BP361278HIB
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：

Recombinant Human adenovirus A serotype 12 E1B protein, large T-antigen
貨號：

CSB-MP361278HIB
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

N/A
Uniprot No.：

P04491
別名：

E1B 55 kDa protein; E1B-55K; E1B protein; large T-antigen; E1B-495R
種屬：

Human adenovirus A serotype 12 (HAdV-12) (Human adenovirus 12)
蛋白長度：

full length protein
表達區域：

1-482
氨基酸序列

MEREIPPELG LHAGLHVNAA VEGMAEEEGL HLLAGAAFDH AAAADVARGE GGGAEPCGGG EVNMEQQVQE GHVLDSGEGP SCADDRDKQE KKESLKEAAV LSRLTVNLMS RPRLETVYWQ ELQDEFQRGD MHLQYKYSFE QLKTHWLEPW EDMECAIKAF AKLALRPDCS YRITKTVTIT SCAYIIGNGA IVEVDTSDRV AFRCRMQGMG PGVVGLDGIT FINVRFAGDK FKGIMFEANT CLVLHGVYFL NFSNICVESW NKVSARGCTF YGCWKGLVGR PKSKLSVKKC LFEKCVLALI VEGDAHIRHN AASENACFVL LKGMAILKHN MVCGVSDQTM RRFVTCADGN CHTLKTVHIV SHSRHCWPVC DHNMFMRCTI HLGLRRGMFR PSQCNFSHSN IMLEPEVFSR VCLNGVFDLS VELCKVIRYN DDTRHRCRQC ECGSSHLELR PIVLNVTEEL RSDHLTLSCL RTDYESSDED DN
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder Warning: in_array() expects parameter 2 to be array, null given in /www/web/cusabio_cn/public_html/caches/caches_template/default/content/show_product_protein.php on line 662
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Plays a major role to prevent cellular inhibition of viral genome replication. Assembles an SCF-like E3 ubiquitin ligase complex based on the cellular proteins ELOB, ELOC, CUL5 and RBX1, in cooperation with viral E4orf6. This viral RING-type ligase ubiquitinates cellular substrates and targets them to proteasomal degradation: TP53/p53, LIG4, MRE11-RAD50-NBS1 (MRN) complex, ITGA3, DAXX and BLM. Degradation of host TP53/p53 activity is essential for preventing E1A-induced TP53 accumulation that would otherwise lead to cell apoptosis and growth arrest. E1B-55K also inactivates TP53 transcription-factor activity by binding its transactivation domain. E1B-55K also functions as a SUMO1 E3 ligase for TP53 which causes the latter to be sequestered in promyelocytic leukemia (PML) nuclear bodies thereby contributing to maximal inhibition of TP53 function.
亞細胞定位：

Host nucleus. Host cytoplasm.
蛋白家族：

Adenoviridae E1B 55 kDa protein family
數據庫鏈接：

KEGG: vg:1460854