Recombinant Human Zinc finger protein GLIS1 (GLIS1)

中文名稱：

人GLIS1重組蛋白
貨號：

CSB-YP818752HU
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

人GLIS1重組蛋白
貨號：

CSB-EP818752HU
說明書：

MSDS Datasheet
規格：
來源：

E.coli
其他：

中文名稱：

人GLIS1重組蛋白
貨號：

CSB-EP818752HU-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

人GLIS1重組蛋白
貨號：

CSB-BP818752HU
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：

人GLIS1重組蛋白
貨號：

CSB-MP818752HU
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

GLIS1
Uniprot No.：

Q8NBF1
別名：

GLIS1; Zinc finger protein GLIS1; GLI-similar 1
種屬：

Homo sapiens (Human)
蛋白長度：

full length protein
表達區域：

1-620
氨基酸序列

MAEARTSLSA HCRGPLATGL HPDLDLPGRS LATPAPSCYL LGSEPSSGLG LQPETHLPEG SLKRCCVLGL PPTSPASSSP CASSDVTSII RSSQTSLVTC VNGLRSPPLT GDLGGPSKRA RPGPASTDSH EGSLQLEACR KASFLKQEPA DEFSELFGPH QQGLPPPYPL SQLPPGPSLG GLGLGLAGRV VAGRQACRWV DCCAAYEQQE ELVRHIEKSH IDQRKGEDFT CFWAGCVRRY KPFNARYKLL IHMRVHSGEK PNKCMFEGCS KAFSRLENLK IHLRSHTGEK PYLCQHPGCQ KAFSNSSDRA KHQRTHLDTK PYACQIPGCS KRYTDPSSLR KHVKAHSAKE QQVRKKLHAG PDTEADVLTE CLVLQQLHTS TQLAASDGKG GCGLGQELLP GVYPGSITPH NGLASGLLPP AHDVPSRHHP LDATTSSHHH LSPLPMAEST RDGLGPGLLS PIVSPLKGLG PPPLPPSSQS HSPGGQPFPT LPSKPSYPPF QSPPPPPLPS PQGYQGSFHS IQSCFPYGDC YRMAEPAAGG DGLVGETHGF NPLRPNGYHS LSTPLPATGY EALAEASCPT ALPQQPSEDV VSSGPEDCGF FPNGAFDHCL GHIPSIYTDT
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Acts as both a repressor and activator of transcription. Binds to the consensus sequence 5'-GACCACCCAC-3'. By controlling the expression of genes involved in cell differentiation inhibits the lineage commitment of multipotent cells. Prevents, for instance, the differentiation of multipotent mesenchymal cells into adipocyte and osteoblast.
基因功能參考文獻：
1. These results suggest that the hypoxic signaling pathway may play a pivotal role in regulating the reprogramming factor GLIS1, via non-canonical mechanisms involving partner transcription factor rather than by direct HIF transactivation. PMID: 24383088
2. found that allele 'A' of rs797906 SNP increases the risk for late-onset Parkinson Disease in the Han Chinese population. PMID: 22759478
3. results therefore show that Glis1 effectively promotes the direct reprogramming of somatic cells during iPSC generation. PMID: 21654807
4. Transcriptional factor Glis1 is involved in the regulation of aberrant differentiation observed in psoriatic epidermis. PMID: 16417217
亞細胞定位：

Nucleus.
蛋白家族：

GLI C2H2-type zinc-finger protein family
數據庫鏈接：

HGNC: 29525

OMIM: 610378

KEGG: hsa:148979

STRING: 9606.ENSP00000309653

UniGene: Hs.306691