Recombinant Human UNC119-binding protein C5orf30 (C5orf30)

中文名稱：

Recombinant Human UNC119-binding protein C5orf30(C5orf30)
貨號：

CSB-YP842679HU
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

Recombinant Human UNC119-binding protein C5orf30(C5orf30)
貨號：

CSB-EP842679HU
說明書：

MSDS Datasheet
規格：
來源：

E.coli
其他：

中文名稱：

Recombinant Human UNC119-binding protein C5orf30(C5orf30)
貨號：

CSB-EP842679HU-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

Recombinant Human UNC119-binding protein C5orf30(C5orf30)
貨號：

CSB-BP842679HU
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：

Recombinant Human UNC119-binding protein C5orf30(C5orf30)
貨號：

CSB-MP842679HU
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

C5orf30
Uniprot No.：

Q96GV9
別名：

C5orf30; CE030_HUMAN; chromosome 5 open reading frame 30; D1Ertd622e; FLJ25291; UNC119-binding protein C5orf30
種屬：

Homo sapiens (Human)
蛋白長度：

full length protein
表達區域：

1-206
氨基酸序列

MEVDINGESR STLTTLPFPG AEANSPGKAE AEKPRCSSTP CSPMRRTVSG YQILHMDSNY LVGFTTGEEL LKLAQKCTGG EESKAEAMPS LRSKQLDAGL ARSSRLYKTR SRYYQPYEIP AVNGRRRRRM PSSGDKCTKS LPYEPYKALH GPLPLCLLKG KRAHSKSLDY LNLDKMIKEP ADTEVLQYQL QHLTLRGDRV FARNNT
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Regulates the macrophage function, by enhancing the resolution of inflammation and wound repair functions mediated by M2 macrophages. The regulation of macrophage function is, due at least in part, to its ability to inhibit glycolysis. May also play a role in trafficking of proteins via its interaction with UNC119 and UNC119B cargo adapters: may help the release of UNC119 and UNC119B cargo or the recycling of UNC119 and UNC119B. May play a role in ciliary membrane localization via its interaction with UNC119B and protein transport into photoreceptor cells.
基因功能參考文獻：
1. C5orf30 is a previously unidentified negative regulator of tissue damage in rheumatoid arthritis, and this protein may act by modulating the autoaggressive phenotype that is characteristic of synovial fibroblasts PMID: 26316022
2. The variant rs26232, in the first intron of the C5orf30 locus, is associated with the severity of radiologic damage in rheumatoid arthritis and is independent of established prognostic biomarkers. PMID: 23817893
亞細胞定位：

Cytoplasm. Cell projection, cilium.
蛋白家族：

UNC119-binding protein family
組織特異性：

High expression in normal macrophages, monocytes, and cultured rheumatoid arthritis synovial fibroblasts (RASFs), with lower expression in B- and T-cells, and little to no expression in other tissues and cell lines.
數據庫鏈接：

HGNC: 25052

OMIM: 616608

KEGG: hsa:90355

STRING: 9606.ENSP00000326110

UniGene: Hs.482976