Recombinant Human Transcription factor 15 (TCF15)

中文名稱：

人TCF15重組蛋白
貨號：

CSB-YP619636HU
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

人TCF15重組蛋白
貨號：

CSB-EP619636HU
說明書：

MSDS Datasheet
規格：
來源：

E.coli
其他：

中文名稱：

人TCF15重組蛋白
貨號：

CSB-EP619636HU-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

人TCF15重組蛋白
貨號：

CSB-BP619636HU
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：

人TCF15重組蛋白
貨號：

CSB-MP619636HU
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

TCF15
Uniprot No.：

Q12870
別名：

bHLH EC2 protein; bHLHa40; BHLHEC2; Class A basic helix-loop-helix protein 40; EC2; Paraxis; Protein bHLH-EC2; TCF-15; Tcf15; TCF15_HUMAN; Transcription factor 15
種屬：

Homo sapiens (Human)
蛋白長度：

full length protein
表達區域：

1-199
氨基酸序列

MAFALLRPVG AHVLYPDVRL LSEDEENRSE SDASDQSFGC CEGPEAARRG PGPGGGRRAG GGGGAGPVVV VRQRQAANAR ERDRTQSVNT AFTALRTLIP TEPVDRKLSK IETVRLASSY IAHLANVLLL GDSADDGQPC FRAAGSAKGA VPAAADGGRQ PRSICTFCLS NQRKGGGRRD LGGSCLKVRG VAPLRGPRR
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Early transcription factor that plays a key role in somitogenesis, paraxial mesoderm development and regulation of stem cell pluripotency. Essential for the mesenchymal to epithelial transition associated with somite formation. Required for somite morphogenesis, thereby regulating patterning of the axial skeleton and skeletal muscles. Required for proper localization of somite epithelium markers during the mesenchymal to epithelial transition. Also plays a key role in regulation of stem cell pluripotency. Promotes pluripotency exit of embryonic stem cells (ESCs) by priming ESCs for differentiation. Acts as a key regulator of self-renewal of hematopoietic stem cells (HSCs) by mediating HSCs quiescence and long-term self-renewal. Together with MEOX2, regulates transcription in heart endothelial cells to regulate fatty acid transport across heart endothelial cells. Acts by forming a heterodimer with another helix-loop-helix (bHLH) protein, such as TCF3/E12, that binds DNA on E-box motifs (5'-CANNTG-3') and activates transcription of target genes.
基因功能參考文獻：
1. Genetic variation in MEOX2, but not TCF15, is a strong predictor of CHD. Further experimental studies should elucidate the underlying molecular mechanisms. PMID: 26428460
2. Microarray profiling on freshly isolated ECs had a genetic signature for microvascular heart ECs and identified Meox2/Tcf15 heterodimers as novel transcriptional determinants. This signature was similar in skeletal muscle and adipose tissue endothelium. PMID: 25561514
3. Activation of TGFbeta recruits p300 to the KLF5-Smad complex to acetylate KLF5, and the complex with acetylated KLF5 binds to the Smad binding element and alters the binding of other factors to p15 promoter to induce its transcription PMID: 19419955
亞細胞定位：

Nucleus.
數據庫鏈接：

HGNC: 11627

OMIM: 601010

KEGG: hsa:6939

STRING: 9606.ENSP00000246080

UniGene: Hs.437