Recombinant Human Trafficking kinesin-binding protein 1 (TRAK1), partial

中文名稱：

人TRAK1重組蛋白
貨號：

CSB-YP891465HU
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

人TRAK1重組蛋白
貨號：

CSB-EP891465HU
說明書：

MSDS Datasheet
規格：
來源：

E.coli
其他：

中文名稱：

人TRAK1重組蛋白
貨號：

CSB-EP891465HU-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

人TRAK1重組蛋白
貨號：

CSB-BP891465HU
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：

人TRAK1重組蛋白
貨號：

CSB-MP891465HU
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

TRAK1
Uniprot No.：

Q9UPV9
別名：

TRAK1; KIAA1042; OIP106; Trafficking kinesin-binding protein 1; 106 kDa O-GlcNAc transferase-interacting protein; Protein Milton
種屬：

Homo sapiens (Human)
蛋白長度：

Partial
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Involved in the regulation of endosome-to-lysosome trafficking, including endocytic trafficking of EGF-EGFR complexes and GABA-A receptors. Involved in mitochondrial motility. When O-glycosylated, abolishes mitochondrial motility. Crucial for recruiting OGT to the mitochondrial surface of neuronal processes. TRAK1 and RHOT form an essential protein complex that links KIF5 to mitochondria for light chain-independent, anterograde transport of mitochondria.
基因功能參考文獻：
1. Data show that the ADP-ribosylation factor 6 (Arf6)-trafficking kinesin protein 1 (trak1) promote the anterograde trafficking of mitochondria. PMID: 29992963
2. This study confirms the role of TRAK1 in mitochondrial dynamics and constitutes the first report of this gene in association with a severe neurodevelopmental disorder. PMID: 28364549
3. This study showed that the TRAK1 was prevalently localized in axons of hippocampal and cortical neurons. PMID: 25653102
4. Data suggest that vitamin D receptor target genes (TRAK1; DUSP10, dual specificity phosphatase 10; NRIP1, nuclear receptor interacting protein 1; THBD, thrombomodulin) can be used as markers for individual's response to vitamin D3 supplements. PMID: 24975273
5. By mapping and mutating four key sites of GlcNAc addition in hMilton1 (hMilton1Qmut), study demonstrated that Milton is the key and essential substrate through which OGT inhibits mitochondrial motility. PMID: 24995978
6. Details of a robust association of DISC1 with mitochondrial transport complexes containing TRAK1 and Miro1. PMID: 24092329
7. The results of this study established a key role for mammalian TRAK1 proteins in axonal and dendritic targeting of mitochondria. PMID: 23395375
8. MGb2-Ag/TRAK1 may play an important role in the development of colorectal cancer (CRC) and may be a valuable prognostic indicator of CRC. PMID: 21573901
9. GRIF-1 and OIP106 have roles in protein and/or organelle transport in excitable cells in a manner analogous to glutamate receptor-interacting-protein 1 PMID: 15644324
10. Data show that Trak1 interacts with hepatocyte-growth-factor-regulated tyrosine kinase substrate (Hrs), an essential component of the endosomal sorting and trafficking machinery. PMID: 18675823
11. TRAK1/MGb2-Ag is a promising diagnostic marker for gastric cancer and may help to detect signet-ring cell carcinoma and mucinous adenocarcinoma PMID: 18986759
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亞細胞定位：

Cytoplasm. Nucleus. Mitochondrion. Early endosome. Endosome. Mitochondrion membrane. Cytoplasm, cell cortex.
組織特異性：

High expression in spinal cord and moderate expression in all other tissues and specific brain regions examined. Expressed in all cell lines examined.
數據庫鏈接：

HGNC: 29947

OMIM: 608112

KEGG: hsa:22906

STRING: 9606.ENSP00000328998

UniGene: Hs.535711