Recombinant Human Testis-specific Y-encoded-like protein 5 (TSPYL5)

中文名稱：

人TSPYL5重組蛋白
貨號：

CSB-YP768219HU
說明書：

MSDS Datasheet
規(guī)格：
來源：

Yeast
其他：

中文名稱：

人TSPYL5重組蛋白
貨號：

CSB-EP768219HU
說明書：

MSDS Datasheet
規(guī)格：
來源：

E.coli
其他：

中文名稱：

人TSPYL5重組蛋白
貨號：

CSB-EP768219HU-B
說明書：

MSDS Datasheet
規(guī)格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

人TSPYL5重組蛋白
貨號：

CSB-BP768219HU
說明書：

MSDS Datasheet
規(guī)格：
來源：

Baculovirus
其他：

中文名稱：

人TSPYL5重組蛋白
貨號：

CSB-MP768219HU
說明書：

MSDS Datasheet
規(guī)格：
來源：

Mammalian cell
其他：

產(chǎn)品詳情
產(chǎn)品評價
靶點詳情

產(chǎn)品詳情

純度：

>85% (SDS-PAGE)
基因名：

TSPYL5
Uniprot No.：

Q86VY4
別名：

KIAA1750; OTTHUMP00000227724; Testis-specific Y-encoded-like protein 5; TSPY like 5; TSPY-like protein 5; Tspyl5; TSYL5_HUMAN
種屬：

Homo sapiens (Human)
蛋白長度：

full length protein
表達區(qū)域：

1-417
氨基酸序列

MSGRSRGRKS SRAKNRGKGR AKARVRPAPD DAPRDPDPSQ YQSLGEDTQA AQVQAGAGWG GLEAAASAQL LRLGEEAACR LPLDCGLALR ARAAGDHGQA AARPGPGKAA SLSERLAADT VFVGTAGTVG RPKNAPRVGN RRGPAGKKAP ETCSTAGRGP QVIAGGRQKK GAAGENTSVS AGEEKKEERD AGSGPPATEG SMDTLENVQL KLENMNAQAD RAYLRLSRKF GQLRLQHLER RNHLIQNIPG FWGQAFQNHP QLASFLNSQE KEVLSYLNSL EVEELGLARL GYKIKFYFDR NPYFQNKVLI KEYGCGPSGQ VVSRSTPIQW LPGHDLQSLS QGNPENNRSF FGWFSNHSSI ESDKIVEIIN EELWPNPLQF YLLSEGARVE KGKEKEGRQG PGKQPMETTQ PGVSQSN
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產(chǎn)品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質(zhì)期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產(chǎn)品評價

靶點詳情

功能：

Involved in modulation of cell growth and cellular response to gamma radiation probably via regulation of the Akt signaling pathway. Involved in regulation of p53/TP53. Suppresses p53/TP53 protein levels and promotes its ubiquitination; the function is dependent on USP7 and independent on MDM2. Proposed to displace p53/TP53 from interaction with USP7.
基因功能參考文獻：
1. The expression of spermatogenic phenotypes of TSPY1 defects is independent of variations in TSPYL1 and TSPYL5 in the Han Chinese population. PMID: 28847364
2. Transcriptome analysis of MUC16 KD showed a downregulation (P = 0.005) of TSPYL5 gene, which encodes for a testis-specific Y-like protein...Also, MUC16 overexpression induced cisplatin and gemcitabine resistance by downregulation of p53 PMID: 28196872
3. More advanced tumor tissues had an inverse correlation between methylation and TSPYL5 gene or protein expression. TSPYL5 may play a role in sensitivity to chemotherapy likely by modulating pleiotropic protein such as CDKN1A. PMID: 28235398
4. Increasing the expression of TSPYL5 in HT29 cells or inhibiting miR-19-5p promotes apoptosis of HT29 cells. PMID: 29240449
5. Overexpression of miR-629 promoted the cell ability of migration and invasion and reduced ovarian cancer cell apoptosis. In addition, elevated cancer inhibition ability of TSPYL5 induced by the miR-629 inhibitor was significantly blocked by inhibition of TSPYL5. PMID: 28972400
6. TSPYL5 overexpression is associated with Down syndrome. PMID: 26911678
7. Suggest that hypermethylation of ACP1, BMP4, and TSPYL5 are common events in HCC and could be used as potentially detectable biomarkers in HCC tissues. PMID: 26386860
8. TSPYL5 knockdown decreased, and overexpression increased aromatase (CYP19A1) expression through the skin/adipose (I.4) promoter. PMID: 23518928
9. Data identify TSPYL5 as a suppressor of p53 function through its interaction with USP7. PMID: 21170034
10. This study provides the first demonstration that TSPYL5 modulates cell growth and sensitization of cells to the detrimental effects of damaging agents via regulation of p21(WAF1/Cip1) and PTEN/AKT pathway. PMID: 20079711
11. aberrant methylation at a CpG island of TSPYL5 may play an important role in development of gastric cancers PMID: 18059362
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蛋白家族：

Nucleosome assembly protein (NAP) family
數(shù)據(jù)庫鏈接：

HGNC: 29367

OMIM: 614721

KEGG: hsa:85453

STRING: 9606.ENSP00000322802

UniGene: Hs.173094