Recombinant Human Target of Myb protein 1 (TOM1)

中文名稱：

人TOM1重組蛋白
貨號：

CSB-YP024043HU
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

人TOM1重組蛋白
貨號：

CSB-EP024043HU
說明書：

MSDS Datasheet
規格：
來源：

E.coli
其他：

中文名稱：

人TOM1重組蛋白
貨號：

CSB-EP024043HU-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

人TOM1重組蛋白
貨號：

CSB-BP024043HU
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：

人TOM1重組蛋白
貨號：

CSB-MP024043HU
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

TOM1
Uniprot No.：

O60784
別名：

TOM1; Target of Myb protein 1
種屬：

Homo sapiens (Human)
蛋白長度：

Full length protein
表達區域：

1-492
氨基酸序列

MDFLLGNPFS SPVGQRIEKA TDGSLQSEDW ALNMEICDII NETEEGPKDA LRAVKKRIVG NKNFHEVMLA LTVLETCVKN CGHRFHVLVA SQDFVESVLV RTILPKNNPP TIVHDKVLNL IQSWADAFRS SPDLTGVVTI YEDLRRKGLE FPMTDLDMLS PIHTPQRTVF NSETQSGQDS VGTDSSQQED SGQHAAPLPA PPILSGDTPI APTPEQIGKL RSELEMVSGN VRVMSEMLTE LVPTQAEPAD LELLQELNRT CRAMQQRVLE LIPQIANEQL TEELLIVNDN LNNVFLRHER FERFRTGQTT KAPSEAEPAA DLIDMGPDPA ATGNLSSQLA GMNLGSSSVR AGLQSLEASG RLEDEFDMFA LTRGSSLADQ RKEVKYEAPQ ATDGLAGALD ARQQSTGAIP VTQACLMEDI EQWLSTDVGN DAEEPKGVTS EEFDKFLEER AKAADRLPNL SSPSAEGPPG PPSGPAPRKK TQEKDDDMLF AL
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder Warning: in_array() expects parameter 2 to be array, null given in /www/web/cusabio_cn/public_html/caches/caches_template/default/content/show_product_protein.php on line 662
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

May be involved in intracellular trafficking. Probable association with membranes.
基因功能參考文獻：
1. This study demonstrated that Tom1 is localized in dystrophic neurites of brain in patient with Alzheimer's disease. PMID: 27206884
2. Tom1 modulates binding of Tollip to phosphatidylinositol 3-phosphate via a coupled folding and binding mechanism. PMID: 26320582
3. candidate multiple myeloma risk locus PMID: 26007630
4. phosphatidylinositol 5-monophosphate (PI5P) enrichment in signaling endosomes prevents endosomal maturation through the recruitment of TOM1, and point to a new function of PI5P in regulating discrete maturation steps in the endosomal system. PMID: 25588840
5. It was shown that that myosin VI, in concert with Tom1, plays a crucial role in autophagy. Tom1 was identified as a myosin VI binding partner on endosomes. PMID: 23023224
6. TOM1 is a microRNA-126 target that may have an important role in regulating innate immune responses in the cystic fibrosis lung. PMID: 20083669
7. a Tom1-Tollip complex functions as a factor that links polyubiquitinated proteins to clathrin PMID: 14563850
8. marked recruitment of TOM1 to endosomes was observed in cells overexpressing endofin or its carboxyl-terminal fragment PMID: 14613930
9. Tollip and Tom1 form a complex and regulate endosomal trafficking of ubiquitinated proteins PMID: 15047686
10. The results suggest that TOM1 is an important molecule for membrane recruitment of clathrin, and that endofin is able to exploit this recruitment at the endosome. PMID: 15657082
11. A 3-marker haplotype of SNPs within TOM1 was associated with psychotic bipolar affective disorder linkage PMID: 17671966
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亞細胞定位：

Cytoplasm. Membrane; Peripheral membrane protein.
蛋白家族：

TOM1 family
組織特異性：

Widely expressed. Highly expressed in skeletal muscle, heart, placenta and liver.
數據庫鏈接：

HGNC: 11982

OMIM: 604700

KEGG: hsa:10043

STRING: 9606.ENSP00000413697

UniGene: Hs.474705