Recombinant Human Synaptotagmin-like protein 2 (SYTL2), partial

中文名稱：

人SYTL2重組蛋白
貨號：

CSB-YP867200HU
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

人SYTL2重組蛋白
貨號：

CSB-EP867200HU
說明書：

MSDS Datasheet
規格：
來源：

E.coli
其他：

中文名稱：

人SYTL2重組蛋白
貨號：

CSB-EP867200HU-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

人SYTL2重組蛋白
貨號：

CSB-BP867200HU
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：

人SYTL2重組蛋白
貨號：

CSB-MP867200HU
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

SYTL2
Uniprot No.：

Q9HCH5
別名：

Breast cancer-associated antigen SGA-72M; CHR11SYT; EXO4; Exophilin-4; FLJ20163; FLJ21219; KIAA1597; MGC102768; SGA72M; SLP2; SLP2A; Synaptotagmin-like protein 2; SYTL2; SYTL2_HUMAN
種屬：

Homo sapiens (Human)
蛋白長度：

Partial
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Isoform 1 acts as a RAB27A effector protein and plays a role in cytotoxic granule exocytosis in lymphocytes. It is required for cytotoxic granule docking at the immunologic synapse. Isoform 4 binds phosphatidylserine (PS) and phosphatidylinositol-4,5-bisphosphate (PIP2) and promotes the recruitment of glucagon-containing granules to the cell membrane in pancreatic alpha cells. Binding to PS is inhibited by Ca(2+) while binding to PIP2 is Ca(2+) insensitive.
基因功能參考文獻：
1. Overexpression of SYTL2 promoted metastatic potential. PMID: 27220283
2. SLP2 may play an important role in tumorigenesis of esophageal squamous cell carcinoma. PMID: 21223688
3. A high expression level of SLP-2 may be associating with the development of invasion and metastasis in laryngeal squamous cell carcinoma and breast cancer. PMID: 20654157
4. Calmodulin suppresses synaptotagmin-2 transcription in cortical neurons PMID: 20729199
5. Exophilin4/Slp2-a is specifically expressed in pancreatic alpha cells. PMID: 17182843
6. These results suggest that both Slp1 and Slp2-a may form part of a docking complex, capturing secretory lysosomes at the immunological synapse. PMID: 18266782
7. Rab27a recruits Slp2a-hem on vesicular structures in peripheral CTLs and following CTL-target cell conjugate formation, the Slp2a-hem/Rab27a complex colocalizes with perforin-containing granules at the immunologic synapse PMID: 18812475
8. Rab27A/Slp2a expression in limb girdle muscular dystrophy 2B muscle provides a compensatory vesicular trafficking pathway that is able to repair membrane damage in the absence of dysferlin. PMID: 18832576
9. occurrence of an unusual TG 3' splice site in intron 9 PMID: 17672918
10. Synaptotagmin-like protein 2-a (Slp2-a) contains an N-terminal Slp homology domain (SHD) (PMID: 11327731). The SHD of Slp2-a specifically and directly binds the GTP-bound form of Rab27A. PMID: 11773082
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亞細胞定位：

[Isoform 1]: Cytoplasm. Cell membrane.; [Isoform 4]: Cell membrane.
組織特異性：

Isoform 1 is expressed in hematopoietic lineages with a strong expression in CD4 and CD8 T-lymphocytes. It is also widely expressed in nonhematopoietic tissues. Isoform 5 is expressed only in nonhematopoietic tissues. Isoform 4 is expressed in pancreatic
數據庫鏈接：

HGNC: 15585

OMIM: 612880

KEGG: hsa:54843

STRING: 9606.ENSP00000346576

UniGene: Hs.369520