Recombinant Human Synaptotagmin-like protein 1 (SYTL1)

中文名稱：

人SYTL1重組蛋白
貨號：

CSB-YP815582HU
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

人SYTL1重組蛋白
貨號：

CSB-EP815582HU
說明書：

MSDS Datasheet
規格：
來源：

E.coli
其他：

中文名稱：

人SYTL1重組蛋白
貨號：

CSB-EP815582HU-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

人SYTL1重組蛋白
貨號：

CSB-BP815582HU
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：

人SYTL1重組蛋白
貨號：

CSB-MP815582HU
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

SYTL1
Uniprot No.：

Q8IYJ3
別名：

exophilin 7; Exophilin-7; JFC1; NADPH oxidase related, C2 domain containing protein; Protein JFC1; PSGL 1; SLP1; Synaptotagmin-like protein 1; SYTL1; SYTL1_HUMAN
種屬：

Homo sapiens (Human)
蛋白長度：

full length protein
表達區域：

1-562
氨基酸序列

MPQRGHPSQE GLWALPSLPM AHGPKPETEG LLDLSFLTEE EQEAIAGVLQ RDARLRQLEE GRVSKLRASV ADPGQLKILT GDWFQEARSQ RHHNAHFGSD LVRASMRRKK STRGDQAPGH DREAEAAVKE KEEGPEPRLT IDEAPQERLR ETEGPDFPSP SVPLKASDPE EASQAQEDPG QGDQQVCAEE ADPELEPASG GEQEPRPQQA QTKAASQILE NGEEAPGPDP SLDRMLSSSS SVSSLNSSTL SGSQMSLSGD AEAVQVRGSV HFALHYEPGA AELRVHVIQC QGLAAARRRR SDPYVKSYLL PDKQSKRKTA VKKRNLNPVF NETLRYSVPQ AELQGRVLSL SVWHRESLGR NIFLGEVEVP LDTWDWGSEP TWLPLQPRVP PSPDDLPSRG LLALSLKYVP AGSEGAGLPP SGELHFWVKE ARDLLPLRAG SLDTYVQCFV LPDDSQASRQ RTRVVRRSLS PVFNHTMVYD GFGPADLRQA CAELSLWDHG ALANRQLGGT RLSLGTGSSY GLQVPWMDST PEEKQLWQAL LEQPCEWVDG LLPLRTNLAP RT
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder Warning: in_array() expects parameter 2 to be array, null given in /www/web/cusabio_cn/public_html/caches/caches_template/default/content/show_product_protein.php on line 662
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

May play a role in vesicle trafficking. Binds phosphatidylinositol 3,4,5-trisphosphate. Acts as a RAB27A effector protein and may play a role in cytotoxic granule exocytosis in lymphocytes.
基因功能參考文獻：
1. results reveal that MEIS1, through induction of SYTL1, promotes leukemogenesis and supports leukemic cell homing and engraftment, facilitating interactions between leukemic cells and bone marrow stroma. PMID: 27018596
2. High Expression of secretory leukocyte protease inhibitor is associated with metastasis in colorectal cancer. PMID: 25441765
3. SLPI regulation and activity is altered in the nasal mucosa of smokers. PMID: 24285265
4. during exocytosis, actin depolymerization commences near the secretory organelle, not the plasma membrane, and secretory granules use a JFC1- and GMIP-dependent molecular mechanism to traverse cortical actin. PMID: 22438581
5. transcriptional activation of JFC1 by the TNFalpha/NF-kappaB pathway is significant in prostate carcinoma cell lines PMID: 12137562
6. evidence that JFC1 differentially regulates the secretion of PSAP and PSA, and that Rab27a and PI3K play a central role in the exocytosis of prostate-specific markers PMID: 16004602
7. Levels of mRNA and immunostaining of the antiproteases elafin and SLPI were enhanced strongly in inflamed versus noninflamed UC. Elafin and SLPI may be added to the list of defensin-like peptides with diminished induction in CD versus UC. PMID: 17200145
8. Slp1 inhibits dense granule secretion in platelets and that Rap1GAP2 modulates secretion by binding to Slp1. PMID: 19528539
9. Jfc1/synaptotagmin-like protein 1 (Slp1) contains an N-terminal Slp homology domain (SHD) (PMID: 11327731). The SHD of Slp1/Jfc1 specifically and directly binds the GTP-bound form of Rab27A (J. Biol. Chem. 277, (2002) 9212-9218; PMID: 11773082). PMID: 11773082
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亞細胞定位：

Cell membrane; Peripheral membrane protein; Cytoplasmic side. Note=Peripheral membrane protein tightly bound to the cytoplasmic side of cellular membranes.
組織特異性：

Highly expressed in bone marrow and lymphoid tissues. Detected at lower levels in cerebellum, occipital lobe, prostate, stomach, kidney, appendix, lung and trachea. Expressed in cytotoxic T-lymphocytes (CTL).
數據庫鏈接：

HGNC: 15584

OMIM: 608042

KEGG: hsa:84958

STRING: 9606.ENSP00000440704

UniGene: Hs.469175