Recombinant Human Synaptopodin (SYNPO), partial

中文名稱：

人SYNPO重組蛋白
貨號：

CSB-YP023020HU
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

人SYNPO重組蛋白
貨號：

CSB-EP023020HU
說明書：

MSDS Datasheet
規格：
來源：

E.coli
其他：

中文名稱：

人SYNPO重組蛋白
貨號：

CSB-EP023020HU-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

人SYNPO重組蛋白
貨號：

CSB-BP023020HU
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：

人SYNPO重組蛋白
貨號：

CSB-MP023020HU
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

SYNPO
Uniprot No.：

Q8N3V7
別名：

KIAA1029; Synaptopodin; SYNPO; SYNPO_HUMAN
種屬：

Homo sapiens (Human)
蛋白長度：

Partial
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Actin-associated protein that may play a role in modulating actin-based shape and motility of dendritic spines and renal podocyte foot processes. Seems to be essential for the formation of spine apparatuses in spines of telencephalic neurons, which is involved in synaptic plasticity.
基因功能參考文獻：
1. The postsynaptic protein, synaptopodin (SYNPO) was significantly down-regulated in both dementia with Lewy bodies and Parkinson's disease dementia subgroups, suggesting a defective synaptic transmission in the demented patients. PMID: 28800743
2. Urine synaptopodin is associated with serum creatinine elevation in the patients with glomerulonephritis including diabetic kidney disease regardless of urine albumin excretion. We suggest that the urine synaptopodin level can predict glomerular damage independently of the urine albumin excretion. PMID: 27604800
3. SYNPO variants are involved in AMPA receptor trafficking and neuronal plasticity, which are associated with cognitive impairment and schizophrenia susceptibility. PMID: 26405221
4. This study identified and confirmed SYNPO protein changes within the postsynaptic density in schizophrenia PMID: 25048004
5. Case Report: immunohistologically detected synaptopodin upregulation in foamy podocytes in Fabry disease due to novel alpha-galactosidase A mutation. PMID: 25295576
6. expression significantly down-regulated in presence of WT1 R458Q mutation PMID: 25145932
7. Shear stress induced actin binding proteins including SYNPO may play a critical role in endothelial wound healing. PMID: 24561195
8. These results suggested that the SA is an important component of the molecular machinery controlling the calcium-dependent accumulation of AMPA-receptors (AMPA-R) at excitatory synapses. [review] PMID: 22217474
9. The urinary mRNA profiles of synaptopodin, podocalyxin, CD2-AP, alpha-actin4, and podocin were found to increase with the progression of diabetic nephropathy. PMID: 21655212
10. Podocyte BK(Ca) channels are regulated by synaptopodin, Rho, and actin microfilaments. PMID: 20630939
11. Heterozygous mutations in the promoters of the ACTN4 and SYNPO genes are found in patients with idiopathic focal segmental glomerulosclerosis. PMID: 19666657
12. interaction with tight junction protein MAGI-1 PMID: 12042308
13. Our data suggest dendritic spine accumulation of SYNPO critically depends on interaction with postsynaptic alpha-actinin and that SYNPO may regulate spine morphology, motility and function via its distinct modes of association with the actin cytoskeleton. PMID: 15659229
14. Synaptopodin, an actin-associated protein, as a novel regulator of RhoA signalling and cell migration in kidney podocytes. PMID: 16622418
15. We conclude that down-regulation of nephrin and synaptopodin is associated with proteinuria in women with preeclampsia. PMID: 17255128
16. Discusses isoforms of mouse Synpo, two of which are consistent with those found in human. PMID: 15841212
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亞細胞定位：

Cytoplasm, cytoskeleton. Cell junction, tight junction. Perikaryon. Cell projection, dendritic spine. Cell junction, synapse, postsynaptic density. Cell junction, synapse. Cytoplasm, cytosol.
蛋白家族：

Synaptopodin family
組織特異性：

Expressed in cerebral cortex.
數據庫鏈接：

HGNC: 30672

OMIM: 608155

KEGG: hsa:11346

STRING: 9606.ENSP00000377789

UniGene: Hs.435228