Recombinant Human Spermatogenesis- and oogenesis-specific basic helix-loop-helix-containing protein 1 (SOHLH1)

中文名稱：

人SOHLH1重組蛋白
貨號：

CSB-YP705513HU
說明書：

MSDS Datasheet
規(guī)格：
來源：

Yeast
其他：

中文名稱：

人SOHLH1重組蛋白
貨號：

CSB-EP705513HU
說明書：

MSDS Datasheet
規(guī)格：
來源：

E.coli
其他：

中文名稱：

人SOHLH1重組蛋白
貨號：

CSB-EP705513HU-B
說明書：

MSDS Datasheet
規(guī)格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

人SOHLH1重組蛋白
貨號：

CSB-BP705513HU
說明書：

MSDS Datasheet
規(guī)格：
來源：

Baculovirus
其他：

中文名稱：

人SOHLH1重組蛋白
貨號：

CSB-MP705513HU
說明書：

MSDS Datasheet
規(guī)格：
來源：

Mammalian cell
其他：

產(chǎn)品詳情
產(chǎn)品評價
靶點詳情

產(chǎn)品詳情

純度：

>85% (SDS-PAGE)
基因名：

SOHLH1
Uniprot No.：

Q5JUK2
別名：

GM110; Helix Loop Helix Protein TOHLH1; Sohlh1; SOLH1_HUMAN; Spermatogenesis- and oogenesis-specific basic helix-loop-helix-containing protein 1; TOHLH1
種屬：

Homo sapiens (Human)
蛋白長度：

full length protein
表達區(qū)域：

1-328
氨基酸序列

MASRCSEPYP EVSRIPTVRG CNGSLSGALS CCEDSARGSG PPKAPTVAEG PSSCLRRNVI SERERRKRMS LSCERLRALL PQFDGRREDM ASVLEMSVQF LRLASALGPS QEQHAILASS KEMWHSLQED VLQLTLSSQI QAGVPDPGTG ASSGTRTPDV KAFLESPWSL DPASASPEPV PHILASSRQW DPASCTSLGT DKCEALLGLC QVRGGLPPFS EPSSLVPWPP GRSLPKAVRP PLSWPPFSQQ QTLPVMSGEA LGWLGQAGPL AMGAAPLGEP AKEDPMLAQE AGSALGSDVD DGTSFLLTAG PSSWPGEWGP GFRAGPPA
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產(chǎn)品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復(fù)溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質(zhì)期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產(chǎn)品評價

靶點詳情

功能：

Transcription regulator of both male and female germline differentiation. Suppresses genes involved in spermatogonial stem cells maintenance, and induces genes important for spermatogonial differentiation. Coordinates oocyte differentiation without affecting meiosis I.
基因功能參考文獻：
1. the expression of Sohlh genes in human tissues PMID: 26375665
2. No association between SOHLH1 SNPs and azoospermia risk in the Chinese population. PMID: 25463635
3. In Chinese and Serbian patients with primary ovarian insufficiency, SOHLH1 was found to be a candidate gene. PMID: 25527234
4. Findings indicate that a splice-acceptor site mutation that probably causes a nonfunctional SOHLH1 protein results in nonobstructive azoospermia by the lack of normal spermatogenesis. PMID: 20506135
5. Observational study of gene-disease association. (HuGE Navigator) PMID: 20506135
6. Sohlh1 and Lhx8 are two germ cell-specific, critical regulators of oogenesis PMID: 16690745
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相關(guān)疾病：

Ovarian dysgenesis 5 (ODG5)
亞細胞定位：

Cytoplasm. Nucleus.
數(shù)據(jù)庫鏈接：

HGNC: 27845

OMIM: 610224

KEGG: hsa:402381

STRING: 9606.ENSP00000404438

UniGene: Hs.120464