Recombinant Human Signal peptide, CUB and EGF-like domain-containing protein 2 (SCUBE2), partial

中文名稱：

人SCUBE2重組蛋白
貨號：

CSB-YP865101HU
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

人SCUBE2重組蛋白
貨號：

CSB-EP865101HU
說明書：

MSDS Datasheet
規格：
來源：

E.coli
其他：

中文名稱：

人SCUBE2重組蛋白
貨號：

CSB-EP865101HU-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

人SCUBE2重組蛋白
貨號：

CSB-BP865101HU
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：

人SCUBE2重組蛋白
貨號：

CSB-MP865101HU
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

SCUBE2
Uniprot No.：

Q9NQ36
別名：

4932442O19Rik; Cegb1; Cegf1; CEGP1; Cegp1 protein; CUB domain and EGF-like repeat containing 1; FLJ16792; FLJ35234; ICRFP703B1614Q5.1; MGC133057; Protein CEGP1; RGD1563998; SCUB2_HUMAN; Scube2; Signal peptide; CUB and EGF-like domain-containing protein 2; Signal peptide; CUB domain; EGF-like 2
種屬：

Homo sapiens (Human)
蛋白長度：

Partial
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Lipid-binding protein required for SHH long-range signaling by binding to the dually lipid-modified SHH (ShhNp) and by promoting ShhNp mobilization, solubilization and release from the cell membrane. Acts by enhancing the proteolytic processing (shedding) of the lipid-modified N- and C- terminal of ShhNp at the cell surface. Synergizes with DISP1 to increase SHH secretion. Probable cell surface coreceptor for VEGFR2 involved in VEGFR2-mediated angiogenesis.
基因功能參考文獻：
1. Overexpression of SCUBE2 inhibits non-small cell lung cancer cell proliferation and invasion through suppressing the Sonic hedgehog signaling pathway. PMID: 29883759
2. Results confirm that heparan sulfate (HS) proteoglycans enrich Scube2 at the surface of Shh-producing cells and that Scube2-regulated proteolytic Shh processing and release depends on specific HS. PMID: 27199253
3. Endothelial SCUBE2 may be a novel coreceptor for VEGFR2 and potentiate VEGF-induced signaling in adult angiogenesis. PMID: 27834687
4. The Sonic hedgehog (Shh) signaling pathway was involved in the inhibitory effect of SCUBE2 overexpression on glioma cells. PMID: 27697090
5. Overexpression of SCUBE2 is associated with Breast Cancer Recurrence. PMID: 27165221
6. SCUBE2 expression was decreased at the transcriptional and translational levels in colorectal cancer tissues and significantly associated with clinical stage, the depth of tumor invasion, lymphnode metastasis, distant metastasis and histological grade. PMID: 25672935
7. Sheddases and Scube2 act cooperatively to increase the pool of soluble bioactive Shh. PMID: 24522195
8. Tumor suppressor SCUBE2 inhibits breast-cancer cell migration and invasion through the reversal of epithelial-mesenchymal transition. PMID: 24213532
9. data suggest that signal peptide CUB domain (SCUBE2), like in breast cancer, associates with estrogen receptor alpha and might have a potential as prognostic or predictive marker in endometrial cancer PMID: 24053619
10. Via obligate assistance of Scube1 and 3, Scube2 plays a center role to recruit dually lipid-modified Hedgehog transferred from Dispatched A (DispA), increasing Hh secretion by promoting its solubility. PMID: 24084593
11. Domain and functional analysis of a novel breast tumor suppressor protein, SCUBE2. PMID: 21652720
12. identification as secreted protein that is expressed in vascular endothelium and may play important roles in development, inflammation, and thrombosis PMID: 12270931
13. Altered SCUBE2 expression is important in breast cancer progression and SCUBE2 may serve as a useful prognostic marker. PMID: 19369267
14. The full-length cDNA of human SCUBE2 was isolated and the role in the hedgehog signalling cascade, was studied. PMID: 19480626
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亞細胞定位：

Secreted. Cell surface.
組織特異性：

Expressed in a broad spectrum of adult tissues.
數據庫鏈接：

HGNC: 30425

OMIM: 611747

KEGG: hsa:57758

UniGene: Hs.523468