Recombinant Human Serine protease inhibitor Kazal-type 2 (SPINK2)

中文名稱：

人SPINK2重組蛋白
貨號：

CSB-YP022576HU
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

人SPINK2重組蛋白
貨號：

CSB-EP022576HU
說明書：

MSDS Datasheet
規格：
來源：

E.coli
其他：

中文名稱：

人SPINK2重組蛋白
貨號：

CSB-EP022576HU-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

人SPINK2重組蛋白
貨號：

CSB-BP022576HU
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：

人SPINK2重組蛋白
貨號：

CSB-MP022576HU
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

SPINK2
Uniprot No.：

P20155
別名：

SPINK2Serine protease inhibitor Kazal-type 2; Acrosin-trypsin inhibitor; Epididymis tissue protein Li 172; HUSI-II
種屬：

Homo sapiens (Human)
蛋白長度：

Full Length of Mature Protein
表達區域：

24-84
氨基酸序列

QFGLFSK YRTPNCSQYR LPGCPRHFNP VCGSDMSTYA NECTLCMKIR EGGHNIKIIR NGPC
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder Warning: in_array() expects parameter 2 to be array, null given in /www/web/cusabio_cn/public_html/caches/caches_template/default/content/show_product_protein.php on line 662
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

As a strong inhibitor of acrosin, it is required for normal spermiogenesis. It probably hinders premature activation of proacrosin and other proteases, thus preventing the cascade of events leading to spermiogenesis defects. May be involved in the regulation of serine protease-dependent germ cell apoptosis. It also inhibits trypsin.
基因功能參考文獻：
1. These results demonstrate that SPINK2 is necessary to neutralize proteases during their cellular transit toward the acrosome and that its deficiency induces a pathological continuum ranging from oligoasthenoteratozoospermia in heterozygotes to azoospermia in homozygotes. PMID: 28554943
2. Data showed that the expression level of SPINK2 is significantly elevated in most leukemia cell lines except B-lymphoblast TK-6 cells. Data demonstrated that Arg(24) at the P1 site is crucial for the specificity of SPINK2 on target enzyme. PMID: 19422058
亞細胞定位：

Secreted. Cytoplasmic vesicle, secretory vesicle, acrosome.
組織特異性：

Expressed in epididymis (at protein level).
數據庫鏈接：

HGNC: 11245

OMIM: 605753

KEGG: hsa:6691

UniGene: Hs.98243