Recombinant Human Retinoic acid early transcript 1G protein (RAET1G), partial

中文名稱：

人RAET1G重組蛋白
貨號：

CSB-YP750234HU
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

人RAET1G重組蛋白
貨號：

CSB-EP750234HU
說明書：

MSDS Datasheet
規格：
來源：

E.coli
其他：

中文名稱：

人RAET1G重組蛋白
貨號：

CSB-EP750234HU-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

人RAET1G重組蛋白
貨號：

CSB-BP750234HU
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：

人RAET1G重組蛋白
貨號：

CSB-MP750234HU
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

RAET1G
Uniprot No.：

Q6H3X3
別名：

RAET1G; ULBP5; UL-16 binding protein 5; Retinoic acid early transcript 1G protein
種屬：

Homo sapiens (Human)
蛋白長度：

Partial
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Binds and activates the KLRK1/NKG2D receptor, mediating natural killer cell cytotoxicity.; Down-regulates the expression of KLRK1 and stimulates natural killer cells to secrete IFNG.; Stimulates natural killer cells to secrete IFNG.
基因功能參考文獻：
1. Human anaplastic thyroid carcinoma cells are sensitive to NK cell-mediated lysis via ULBP2/5/6 and chemoattract NK cells. PMID: 25212604
2. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) PMID: 20379614
3. RAET1G is regulated post-translationally to produce a GPI-anchored isoform PMID: 20304922
4. Observational study of genotype prevalence. (HuGE Navigator) PMID: 20219610
5. Binds the activating receptor NKG2D and the the human cytomegalovirus protein UL16. PMID: 15240696
6. the expression patterns of ULBP5RAET1G are very similar to the well-characterised NKG2D ligand, MICA. However the two isoforms of ULBP5/RAET1G have very different cellular localisations that are likely to reflect unique functionality. PMID: 19223974
7. RAET1G, like ULBP2, appears broadly expressed, but exhibits a lower apparent avidity for NKG2D due to a mutation in the center of the MHC-like fold. PMID: 19424970
8. Observational study of genotype prevalence. (HuGE Navigator) PMID: 19688209
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亞細胞定位：

[Isoform 1]: Cell membrane; Lipid-anchor, GPI-anchor. Endoplasmic reticulum.; [Isoform 2]: Secreted.
蛋白家族：

MHC class I family
組織特異性：

Isoform 1 is highly expressed in colon and in a number of tumor cell lines and highly restricted in normal tissues. Both isoforms are frequently expressed in cell lines derived from epithelial cancers, and in primary breast cancers.
數據庫鏈接：

HGNC: 16795

OMIM: 609244

KEGG: hsa:353091

STRING: 9606.ENSP00000356329

UniGene: Hs.535023