Recombinant Human Ras-related protein Rab-18 (RAB18)

中文名稱：

人RAB18重組蛋白
貨號：

CSB-EP878835HU
說明書：

MSDS Datasheet
規(guī)格：

￥1344
圖片：
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
其他：

產(chǎn)品詳情
產(chǎn)品評價
相關(guān)產(chǎn)品
靶點詳情

產(chǎn)品詳情

純度：

Greater than 90% as determined by SDS-PAGE.
基因名：

RAB18
Uniprot No.：

Q9NP72
別名：

AA959686; RAB18; RAB18 small GTPase; RAB18; member RAS oncogene family; RAB18_HUMAN; RAB18LI1; Ras related protein Rab 18; Ras-asssociated protein RAB18; Ras-related protein Rab-18; RP11-148B2.1; WARBM3
種屬：

Homo sapiens (Human)
蛋白長度：

Full Length
來源：

E.coli
分子量：

49.7kDa
表達區(qū)域：

1-206aa
氨基酸序列

MDEDVLTTLKILIIGESGVGKSSLLLRFTDDTFDPELAATIGVDFKVKTISVDGNKAKLAIWDTAGQERFRTLTPSYYRGAQGVILVYDVTRRDTFVKLDNWLNELETYCTRNDIVNMLVGNKIDKENREVDRNEGLKFARKHSMLFIEASAKTCDGVQCAFEELVEKIIQTPGLWESENQNKGVKLSHREEGQGGGACGGYC
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
蛋白標簽：

N-terminal GST-tagged
產(chǎn)品提供形式：

Liquid or Lyophilized powder Warning: in_array() expects parameter 2 to be array, null given in /www/web/cusabio_cn/public_html/caches/caches_template/default/content/show_product_protein.php on line 662
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
緩沖液：

If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol.
Note: If you have any special requirement for the glycerol content, please remark when you place the order.
If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質(zhì)期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet & COA：

Please contact us to get it.

產(chǎn)品評價

靶點詳情

功能：

Required for the localization of ZFYVE1 to lipid droplets and for its function in mediating the formation of endoplasmic reticulum-lipid droplets (ER-LD) contacts. Plays a role in apical endocytosis/recycling. Plays a key role in eye and brain development and neurodegeneration.
基因功能參考文獻：
1. The authors found that the previously documented interaction between TRAPPII and COPI was also required for the recruitment of Rab18 to the lipid droplet. PMID: 28003315
2. findings suggest that RAB18 rs3765133 polymorphism affects the development of specific brain regions, particularly the cerebellum, in healthy people. PMID: 24996981
3. RAB18 is the direct target of miR-455-5p in gastric cancer. PMID: 27451075
4. Warburg Micro syndrome is caused by RAB18 deficiency. PMID: 26063829
5. These results suggest that Rab18 has an important role in viral assembly through the trafficking of the hepatitis C virus core protein to lipid droplets. PMID: 24997429
6. High RAB18 expression is associated with glioma. PMID: 24477653
7. Rab18-mediated membrane trafficking of FASN and NS3 facilitates dengue virus replication. PMID: 24696471
8. Rab18 interacts with the HCV nonstructural protein NS5A. PMID: 23935497
9. Hepatitis B virus X protein enhances proliferation of hepatoma cells through Rab18. PMID: 23471881
10. Micro syndrome has been associated with causative mutations in three disease genes: RAB3GAP1, RAB3GAP2 and RAB18. Martsolf syndrome has been associated with a mutation in RAB3GAP2. [Review] PMID: 23176487
11. performed autozygosity mapping in five consanguineous families with Warburg micro syndrome without RAB3GAP1/2 mutations and identified loss-of-function mutations in RAB18 PMID: 21473985
12. Rab18 regulates lipid droplet-associated membrane formation PMID: 15914536
13. analysis of a novel splice variant of human Rab18 gene PMID: 16147880
14. Rab18 is reduced in pituitary tumors causing acromegaly and its overexpression reverts growth hormone hypersecretion. PMID: 18349058
15. Rab18 and Rab43 have key roles in ER-Golgi trafficking. PMID: 18664496
16. Rab18 is recruited to lipid droplets during lipolysis PMID: 16207721
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相關(guān)疾病：

Warburg micro syndrome 3 (WARBM3)
亞細胞定位：

Apical cell membrane. Lipid droplet.
蛋白家族：

Small GTPase superfamily, Rab family
組織特異性：

Ubiquitous.
數(shù)據(jù)庫鏈接：

HGNC: 14244

OMIM: 602207

KEGG: hsa:22931

STRING: 9606.ENSP00000349415

UniGene: Hs.406799