Recombinant Human Ras-GEF domain-containing family member 1B (RASGEF1B)

中文名稱：

人RASGEF1B重組蛋白
貨號：

CSB-YP610807HU
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

人RASGEF1B重組蛋白
貨號：

CSB-EP610807HU
說明書：

MSDS Datasheet
規格：
來源：

E.coli
其他：

中文名稱：

人RASGEF1B重組蛋白
貨號：

CSB-EP610807HU-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

人RASGEF1B重組蛋白
貨號：

CSB-BP610807HU
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：

人RASGEF1B重組蛋白
貨號：

CSB-MP610807HU
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

RASGEF1B
Uniprot No.：

Q0VAM2
別名：

FLJ31695; GPI gamma-4; GPIG4; MGC46251; Ras-GEF domain-containing family member 1B; RasGEF domain family member 1B; RASGEF1B; RGF1B_HUMAN
種屬：

Homo sapiens (Human)
蛋白長度：

full length protein
表達區域：

1-473
氨基酸序列

MPQTPPFSAM FDSSGYNRNL YQSAEDSCGG LYYHDNNLLS GSLEALIQHL VPNVDYYPDR TYIFTFLLSS RLFMHPYELM AKVCHLCVEH QRLSDPDSDK NQMRKIAPKI LQLLTEWTET FPYDFRDERM MRNLKDLAHR IASGEEQTYR KNVQQMMQCL IRKLAALSQY EEVLAKISST STDRLTVLKT KPQSIQRDII TVCNDPYTLA QQLTHIELER LNYIGPEEFV QAFVQKDPLD NDKSCYSERK KTRNLEAYVE WFNRLSYLVA TEICMPVKKK HRARMIEYFI DVARECFNIG NFNSLMAIIS GMNMSPVSRL KKTWAKVKTA KFDILEHQMD PSSNFYNYRT ALRGAAQRSL TAHSSREKIV IPFFSLLIKD IYFLNEGCAN RLPNGHVNFE KFWELAKQVS EFMTWKQVEC PFERDRKILQ YLLTVPVFSE DALYLASYES EGPENHIEKD RWKSLRSSLL GRV
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Guanine nucleotide exchange factor (GEF) with specificity for RAP2A, it doesn't seems to activate other Ras family proteins (in vitro).
基因功能參考文獻：
1. We show that knockdown of the expression of mcircRasGEF1B reduces LPS-induced ICAM-1 expression. Additionally, we demonstrate that mcircRasGEF1B regulates the stability of mature ICAM-1 mRNAs. PMID: 27362560
2. As an addition to PRKG2 and RASGEFIB genes, we propose to include BMP3 gene as the principal determinant of the observed common phenotype. PMID: 22303795
3. Mutation of the Ser39 in Rap1 changed the specificity and allowed the nucleotide exchange of Rap1(S39F) to be stimulated by RasGEF1B PMID: 19645719
亞細胞定位：

Early endosome. Late endosome. Midbody.
數據庫鏈接：

HGNC: 24881

OMIM: 614532

KEGG: hsa:153020

STRING: 9606.ENSP00000264400

UniGene: Hs.591696