Recombinant Human RAB6-interacting golgin (GORAB)

中文名稱：

人GORAB重組蛋白
貨號：

CSB-YP713131HU
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

人GORAB重組蛋白
貨號：

CSB-EP713131HU
說明書：

MSDS Datasheet
規格：
來源：

E.coli
其他：

中文名稱：

人GORAB重組蛋白
貨號：

CSB-EP713131HU-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

人GORAB重組蛋白
貨號：

CSB-BP713131HU
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：

人GORAB重組蛋白
貨號：

CSB-MP713131HU
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

GORAB
Uniprot No.：

Q5T7V8
別名：

FLJ11752; GO; Golgin RAB6 interacting; GORAB; GORAB_HUMAN; hNTKL BP1; hNTKL-BP1; MGC51263; MGC70512; N terminal kinase like binding protein 1; N-terminal kinase-like-binding protein 1; NTKL binding protein 1; NTKL BP1; NTKL-binding protein 1; NTKL-BP1; NTKLBP 1; NTKLBP1; OTTHUMP00000033164; RAB6-interacting golgin; RP11 545I10.1; SCY1 like 1 binding protein 1; SCY1-like 1-binding protein 1; SCYL1 binding protein 1; SCYL1 BP1; SCYL1-binding protein 1; SCYL1-BP1; SCYL1BP1
種屬：

Homo sapiens (Human)
蛋白長度：

full length protein
表達區域：

1-394
氨基酸序列

MSWAAVLAVA AARFGHFWGC RWPGPMAQGW AGFSEEELRR LKQTKDPFEP QRRLPAKKSR QQLQREKALV EQSQKLGLQD GSTSLLPEQL LSAPKQRVNV QKPPFSSPTL PSHFTLTSPV GDGQPQGIES QPKELGLENS HDGHNNVEIL PPKPDCKLEK KKVELQEKSR WEVLQQEQRL MEEKNKRKKA LLAKAIAERS KRTQAETMKL KRIQKELQAL DDMVSADIGI LRNRIDQASL DYSYARKRFD RAEAEYIAAK LDIQRKTEIK EQLTEHLCTI IQQNELRKAK KLEELMQQLD VEADEETLEL EVEVERLLHE QEVESRRPVV RLERPFQPAE ESVTLEFAKE NRKCQEQAVS PKVDDQCGNS SSIPFLSPNC PNQEGNDISA ALAT
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

基因功能參考文獻：
1. Novel compound heterozygous nonsense mutations were identified in the GORAB gene of a geroderma osteodysplastica patient. PMID: 28807865
2. in the present study a de novo deletion on 1q23.3-q24.2 combined with a GORAB missense mutation leads to a distinctive phenotype with features from Gerodermia osteodysplastica and also short stature, cutis laxa, frequent fractures, facial dysmorphism, cup-shaped ears and intellectual disability PMID: 27604556
3. SCYL1- BP1 affects the cell cycle through increasing steady state levels of Cyclin F and RRM2 proteins, thus constituting a dual regulatory circuit PMID: 25980818
4. SCYL1-BP1 plays a critical role in the regulation of EEA1, BMPR2 and BRCA2 expression. PMID: 25234469
5. SCYL1BP1 can promote the degradation of MDM2 protein and further inhibit the G1/S transition of lung SCC lines. Reintroduction of SCYL1BP1 into lung SCC lines significantly inhibited cell proliferation, migration, invasion and tumor formation. PMID: 25227860
6. Data suggest that SCYL1-BP1 is a novel regulator of the MDM2-p53 feedback loop and that it may be a potential tumor suppressor. PMID: 20849854
7. The chemotaxis signal pathway induced by chemokines CKbeta8 and CKbeta8-1 is mediated via the Gi/Go protein, phospholipase C (PLC) and protein kinase C delta (PKC delta). PMID: 19951712
8. study supplements the limited available data on SCYL1BP1 and further establishes deficiency of this recently described golgin as the only known cause of geroderma osteodysplastica PMID: 19681135
9. assessment of interaction with hPirh2 PMID: 15781263
10. Study demonstrates that gerodermia osteodysplastica is caused by loss-of-function mutations in SCYL1BP1, which is highly expressed in skin and osteoblasts. PMID: 18997784
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相關疾?。?/div>
Geroderma osteodysplasticum (GO)
亞細胞定位：

Cytoplasm. Golgi apparatus.
蛋白家族：

GORAB family
數據庫鏈接：

HGNC: 25676

OMIM: 231070

KEGG: hsa:92344

STRING: 9606.ENSP00000356737

UniGene: Hs.183702