Recombinant Human Protocadherin-12 (PCDH12), partial

中文名稱：

人PCDH12重組蛋白
貨號：

CSB-YP885683HU
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

人PCDH12重組蛋白
貨號：

CSB-EP885683HU
說明書：

MSDS Datasheet
規格：
來源：

E.coli
其他：

中文名稱：

人PCDH12重組蛋白
貨號：

CSB-EP885683HU-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

人PCDH12重組蛋白
貨號：

CSB-BP885683HU
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：

人PCDH12重組蛋白
貨號：

CSB-MP885683HU
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

PCDH12
Uniprot No.：

Q9NPG4
別名：

PCD12_HUMAN; Pcdh12; Protocadherin 12; Protocadherin-12; Vascular cadherin 2; Vascular cadherin-2; Vascular endothelial cadherin 2; Vascular endothelial cadherin-2; VE cadherin 2; VE-cad-2; VE-cadherin-2; VECAD2
種屬：

Homo sapiens (Human)
蛋白長度：

Partial
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Cellular adhesion molecule that may play an important role in cell-cell interactions at interendothelial junctions. Acts as a regulator of cell migration, probably via increasing cell-cell adhesion. Promotes homotypic calcium-dependent aggregation and adhesion and clusters at intercellular junctions. Unable to bind to catenins, weakly associates with the cytoskeleton.
基因功能參考文獻：
1. Genome-wide analysis to determine the genetic cause of a microcephaly syndrome; found that loss of function of PCDH12 leads to recessive congenital microcephaly with profound developmental disability PMID: 27164683
2. PCDH12 may play an important role in human placental development, and proteolytic cleavage in response to external factors, such as cytokines and pathological settings, regulates its activity PMID: 21402705
3. A putative association was also found between protocadherin 12 and cortical folding (asymmetry coefficient of gyrification index). PMID: 19054571
亞細胞定位：

[Protocadherin-12]: Cell membrane; Single-pass type I membrane protein. Cell junction.; [Protocadherin-12, secreted form]: Secreted.
組織特異性：

Expressed in highly vascularized tissues including the heart and placenta, but most tissues contain a low level of expression. Prominent expression in the spleen. Present in villous and extravillous trophoblast (at protein level).
數據庫鏈接：

HGNC: 8657

OMIM: 251280

KEGG: hsa:51294

UniGene: Hs.439474