Recombinant Human Protocadherin-10 (PCDH10), partial
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中文名稱：人PCDH10重組蛋白
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貨號：CSB-EP889183HU-B
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說明書：
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規(guī)格：
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來源：E.coli
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共軛：Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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其他：
產(chǎn)品詳情
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純度：>85% (SDS-PAGE)
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基因名：PCDH10
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Uniprot No.：
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別名：DKFZp761O2023; KIAA1400; MGC133344; OL PCDH; Ortholog of OL pcdh; OTTHUMP00000220001; PCD10_HUMAN; PCDH10; PCDH19; Protocadherin 10 ; Protocadherin-10
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種屬：Homo sapiens (Human)
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蛋白長度：Partial
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蛋白標簽：Tag?type?will?be?determined?during?the?manufacturing?process.
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially. -
產(chǎn)品提供形式：Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand. -
復溶：We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
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儲存條件：Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
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保質期：The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C. -
貨期：Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
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注意事項：Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
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Datasheet ：Please contact us to get it.
產(chǎn)品評價
相關產(chǎn)品
靶點詳情
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功能：Potential calcium-dependent cell-adhesion protein.
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基因功能參考文獻：
- PCDH10 hypermethylation were found in 54.2% (58/107) of DLBCL cases, but only 12.5% (1/8) in reactive lymph node/follicular hyperplasia. PMID: 29202805
- This study provides insights into the tumorigenesis and progression of hepatocellular carcinoma (HCC), and puts forward the novel hypothesis that PCDH10 could be a new biomarker for HCC, or that combined with other molecular markers could increase the specificity and sensitivity of diagnostic tests for HCC. Restoration of PCDH10 could be a valuable therapeutic target for HCC. PMID: 28498423
- we found that the malignant character of GISTs was initiated and amplified by PCDH10 in a process regulated by HOTAIR. In summary, our findings imply that PCDH10 and HOTAIR may be useful markers of disease progression and therapeutic targets. PMID: 27659532
- we found that long noncoding RNA (lncRNA) MALAT1 binds EZH2, suppresses the tumor suppressor PCDH10, and promotes gastric cellular migration and invasion PMID: 26871474
- These findings suggest that Pcdh10 may influence subcellular actin cytoskeletal organization and axon-axon interactions in the course of familial amyloidotic polyneuropathy PMID: 27338109
- PCDH10 methylation in serum is a potential prognostic biomarker for prostate cancer. PMID: 26881880
- Study found that hypermethylation of CpG probes in the promoter regions of HOXA9 and PCDH10 was associated with mature B-cell neoplasms. PMID: 26679037
- Data show that protocadherin 10 (PCDH10) over-expression could significantly induce cell apoptosis, and restrain proliferation, invasion and migration ability of BXPC-3 pancreatic cancer cells. PMID: 26927373
- Our present findings suggested that the hypermethylated CpG site counts of PCDH10 DNA promoter for evaluating the prognosis of GC was reasonable by using the D-BGS PMID: 26406945
- PCDH10 methylation is a potential biomarker that predicts a poor prognosis after curative resection of pathological stage I non-small-cell lung cancer. PMID: 26276761
- PCDH10 antagonized MM cell proliferation via the downregulation of Wnt/beta-catenin/BCL-9 signaling, whereas PCDH10 repressed the expression of AKT to promote the expression of GSK3beta and then to restrain the activation of beta-catenin PMID: 26081897
- These results suggest an important role of p53 in regulating tumor cell migration through activating PCDH10 expression. PMID: 25590240
- Aberrant methylation of PCDH10 predicts worse biochemical recurrence-free survival in patients with prostate cancer after radical prostatectomy. PMID: 25086586
- Gastric cancer patients with 5 or more methylated CpG sites of PCDH10 promoter had significantly poorer survival. PMID: 25260683
- Findings establish a novel PCDH10-Wnt/beta-catenin-MALAT1 regulatory axis that contributes to EEC development. PMID: 25085246
- These results indicate that promoter methylation status of PCDH10, SPARC, and UCHL1 may be used both as prognostic and predictive molecular marker for colorectal cancer patients PMID: 24309322
- Loss of PCDH10 expression is associated with metastasis in colorectal cancer. PMID: 24740680
- suppression of the expression of PCDH10 by RNA interference induces the growth arrest and apoptosis of glioblastoma cells in vitro PMID: 24406169
- study suggests that PCDH10 methylation occurs early in lymphomagenesis. PCDH10 expression was down regulated via promoter hypermethylation in T- and B-cell lymphoma cell lines PMID: 23929756
- The expression of PCDH10 was silenced in hepatocellular carcinoma via de novo DNA methylation. PMID: 22543497
- There was a significant correlation between PCDH10 methylation in cfDNA and tumour tissue in patients with early CRC. PMID: 23839493
- PCDH10 promoter methylation was detected in 59/117 (50.4%) of patients with bladder cancer, and none of 37 (0%) controls. Methylation was significantly associated with advanced stage, high grade, tumour recurrence and larger tumour size. PMID: 23321168
- Downregulated PCDH10 levels correlated with malignant behaviour and poor overall survival in patients with bladder cancer. PMID: 23569128
- PCDH10 methylation is closely associated with malignancy of bladder transitional cell carcinoma PMID: 23171734
- PCDH10 is frequently downregulated by promoter methylation and may serve as a tumor suppressor gene in non-small cell lung cancer. PMID: 23321465
- PCDH10 is an important tumor suppression gene with key roles of suppressing cell proliferation, clonogenicity, and inhibiting cell invasion in the development of colorectal cancer. PMID: 23180019
- PCDH10 gene is a target for epigenetic silencing in multiple myeloma and provides a link between the dysregulation of angiogenesis and DNA methylation. PMID: 22245948
- Data show that expression of PCDH10 is markedly reduced in gastric cancer cells and tissues, and suggest that it functions as a tumor suppressor gene in gastric cancer. PMID: 22206871
- PCDH10 promoter hypermethylation was frequent in both B-cell (81.9%) and T-cell (80%) acute lymphoblastic leukemia (ALL). PMID: 21960365
- genetic and epigenetic deregulation of PCDH10 occurs in a significant portion of medulloblastoma patients PMID: 21597995
- The decreased PCDH10 expression in prostate cancer cells was associated with the aberrant methylation of PCDH10 promoter CpG islands. PMID: 21314642
- Sp1/Sp3 and CBF/NF-Y transcription factors play a crucial role in the basal expression of the human PCDH10 gene. PMID: 21237250
- epigenetic regulation of PCDH10 was associated with carcinogenesis. PMID: 20353276
- Showed aberrant promoter hypermethylation of PCDH10 is assoc'd with downreg'n of gene expression in cervical cancer, and the promoter methylation in the PCDH10 gene occurs at an earliest identifiable stage of low-grade squamous intraepithelial lesion. PMID: 19681120
- Ectopic expression of PCDH10 strongly suppressed tumor cell growth, migration, invasion and colony formation. PMID: 16247458
- These results suggest that OL-pc remodels the motility and adhesion machinery at cell junctions by recruiting the Nap1-WAVE1 complex to these sites and, in turn, promotes the migration of cells. PMID: 18644894
- PCDH10 is a gastric tumor suppressor; its methylation at early stages of gastric carcinogenesis is an independent prognostic factor. PMID: 19084528
- The role of OL-protocadherin-dependent striatal axon growth in neural circuit formation. PMID: 19262141
- field methylation of the PCDH10 gene specifically in the invasion stage of cervical carcinogenesis, which might be used to develop a highly specific diagnostic test for cervical scrapings. PMID: 19709077
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亞細胞定位：Cell membrane; Single-pass type I membrane protein.
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組織特異性：Moderately expressed in all regions of the brain examined, as well as in testis and ovary, and low expression in all other tissues tested.
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