Recombinant Human Protein atonal homolog 1 (ATOH1)

中文名稱：

Recombinant Human Protein atonal homolog 1(ATOH1)
貨號：

CSB-YP846107HU
說明書：

MSDS Datasheet
規格：

￥1146
圖片：
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

純度：

Greater than 90% as determined by SDS-PAGE.
基因名：

ATOH1
Uniprot No.：

Q92858
別名：

ATH1; ATOH1; ATOH1_HUMAN; Atonal homolog 1 (Drosophila); Atonal homolog 1; bHLHa14; Class A basic helix-loop-helix protein 14; hATH1; Helix loop helix protein hATH 1; Helix-loop-helix protein hATH-1; MATH 1; MATH1; Protein atonal homolog 1
種屬：

Homo sapiens (Human)
蛋白長度：

Full Length
來源：

Yeast
分子量：

40.2kDa
表達區域：

1-354aa
氨基酸序列

MSRLLHAEEWAEVKELGDHHRQPQPHHLPQPPPPPQPPATLQAREHPVYPPELSLLDSTDPRAWLAPTLQGICTARAAQYLLHSPELGASEAAAPRDEVDGRGELVRRSSGGASSSKSPGPVKVREQLCKLKGGVVVDELGCSRQRAPSSKQVNGVQKQRRLAANARERRRMHGLNHAFDQLRNVIPSFNNDKKLSKYETLQMAQIYINALSELLQTPSGGEQPPPPPASCKSDHHHLRTAASYEGGAGNATAAGAQQASGGSQRPTPPGSCRTRFSAPASAGGYSVQLDALHFSTFEDSALTAMMAQKNLSPSLPGSILQPVQEENSKTSPRSHRSDGEFSPHSHYSDSDEAS
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
蛋白標簽：

N-terminal 6xHis-tagged
產品提供形式：

Liquid or Lyophilized powder Warning: in_array() expects parameter 2 to be array, null given in /www/web/cusabio_cn/public_html/caches/caches_template/default/content/show_product_protein.php on line 662
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
緩沖液：

If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol.
Note: If you have any special requirement for the glycerol content, please remark when you place the order.
If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet & COA：

Please contact us to get it.

產品評價

靶點詳情

功能：

Transcriptional regulator. Activates E box-dependent transcription in collaboration with TCF3/E47, but the activity is completely antagonized by the negative regulator of neurogenesis HES1. Plays a role in the differentiation of subsets of neural cells by activating E box-dependent transcription.
基因功能參考文獻：
1. Our results suggest that KN promotes goblet cell differentiation by regulating Wnt, Notch, and AhR signals and expression of Hes1 and Hath1. PMID: 29436668
2. The authors discovered tyrosine 78 of Atoh1 is phosphorylated by a Jak2-mediated pathway only in tumor-initiating cells and in human Sonic Hedgehog-type medulloblastoma. PMID: 29168692
3. ATOH1 expression was detected consistently in recurrent and metastatic SHH medulloblastoma. Chromatin immunoprecipitation sequencing and gene expression profiling identified candidate ATOH1 targets in tumor cells involved in development and tumorigenesis. PMID: 28490517
4. These data indicate that the regulation of Atoh1 by the ubiquitin proteasome pathway is necessary for hair cell fate determination and survival. PMID: 27542412
5. ATOH1 is increased in advanced Merkel cell carcinoma (MCC) indicating that ATOH1 is involved in MCC progression. PMID: 27624714
6. Study provides evidence that Sox2 expression is required for the late stages of progenitor cell differentiation to hair cells and stimulates Atoh1 expression through a concentration dependent molecular interaction with the 3' enhancer of Atoh1. PMID: 26988140
7. mutation not found in group of children with sensorineural hearing loss PMID: 26634621
8. Downregulation of Hath1 expression promoted the proliferation and reduced the apoptosis of KUMA5 squamous cell carcinoma cells. PMID: 26648003
9. ATOH1 can induce the differentiation of gastric cancer stem cells. PMID: 25950549
10. ATOH1 acts in concert with other transcription factors to directly regulate the cochlear hair cell phenotype. PMID: 25015561
11. Testosterone-bovine serum albumin and Math1 treatment could promote an increase in hair-cell like cells in the lesser epithelial ridge through proliferation and transdifferentiation. PMID: 25957791
12. Atoh1 epigenetic regulation guides hair cell development in the mammalian cochlea PMID: 26487780
13. Atoh1 protein stabilization induced both a cancer stem cell phenotype and a mucinous phenotype, resulting in the acquisition of chemoresistance in colorectal cancer PMID: 26017781
14. Chicken Atoh1 might have intrinsic functional differences to mammalian Atoh1. PMID: 25412697
15. In this review, expression of the Atoh1 gene in supporting cells, results in their transformation into immature hair cells. PMID: 25648190
16. Data suggest that Atoh1 high expression correlates with a good prognosis and it may serve as a favorable prognostic factor for GIST. PMID: 25400808
17. Expression of Hath1, Muc2, cyclin D1 and p27 in the xenograft tumors was also detected. PMID: 23464457
18. Atoh1 transfection drives highly efficient differentiation of human pluripotent stem cells into dopaminergic neurons. PMID: 24904172
19. cotransfection of Pax2 and Math1 strongly stimulates in situ hair cell regeneration in neomycin-damaged cochlear explants. PMID: 24141260
20. The transcription factor Atoh1, which is both necessary and sufficient for hair cell development. PMID: 23724999
21. the Atoh1 protein regulates malignant potential rather than the differentiation phenotype of mucinous colon cancer (MC), suggesting the mechanism by which MC and signet ring cell carcinoma are more malignant than non-mucinous adenocarcinoma. PMID: 23333391
22. Nuclear expression of Atoh1 was inversely correlated with the differentiation and primary tumor stage of lung cancers and also the downregulation of the Wnt pathway. PMID: 23030416
23. H. pylori up-regulates Hath1 expression through inducing the release of IL-8 in MKN28 cells. PMID: 22786753
24. Transfection of hATOH1 in combination with hTCF3 or hGATA3 induced 2-3X more Pou4f3/GFP cells, and similarly enhanced Pou4f3/GFP and myosin VIIa double-positive cells, when compared to hATOH1 alone PMID: 22985730
25. involved in differentiation of neurons, secretory cells in the gut, and mechanoreceptors including auditory hair cells [review] PMID: 22370966
26. In vivo conversion of pillar cells and Deiters' cells into immature auditory hair cells by Atoh1 is age dependent and resembles normal auditory hair cell development. PMID: 22573682
27. Atoh1 activates cell proliferation within the normally postmitotic cochlear epithelium. PMID: 22573692
28. Math1/Atoh1 ectopic expression significantly reduced cell proliferation and altered cell morphology in Barrett esophagus PMID: 22147253
29. Longitudinal cell formation in the small intestine was regulated by the colocalization of Hath1 and Klf4 that converted Paneth cell differentiation into goblet cell differentiation. PMID: 21125297
30. Atonal homolog 1 is required for growth and differentiation effects of notch/gamma-secretase inhibitors on normal and cancerous intestinal epithelial cells. PMID: 20621629
31. we investigated by immunohistochemistry the expression of Hath1 in 63 neuroendocrine tumors PMID: 19924642
32. Maps to 10q21-22. Candidate gene for optic nerve aplasia and related syndromes. PMID: 11889557
33. Proneural and proneuroendocrine transcription factor expression in cutaneous mechanoreceptor (Merkel) cells and Merkel cell carcinoma PMID: 12209986
34. Hath1 may regulate the expression of MUC2, a mucin secreted by goblet cells, and Hath1 may also be a novel factor normally repressed as a consequence of activation of the Wnt signaling pathway [review] PMID: 16382053
35. Hath1 is one of the transcriptional regulators for MUC6 and MUC5AC in gastric cancer cells. PMID: 16647036
36. Based on these results, we hypothesize that Cdx2 is involved in activating Math1 expression in intestinal epithelial cells. PMID: 16831200
37. HATH1 is an important factor in the up-regulation of MUC2 expression that occurs in mucinous cancers and signet ring carcinomas. PMID: 17000673
38. GSK3beta-dependent protein degradation was switched between Hath1 and beta-catenin by Wnt signaling, leading to the dramatic alteration of cell status between proliferation and differentiation in colon cancer PMID: 17241872
39. In the chimeric environment, genotypically wild-type cells that possess Math1 have the competence to differentiate into hair cells by providing appropriate environmental interactions. PMID: 17397818
40. Patients with ATOH1-expressing adenocarcinomas might have a worse prognosis. PMID: 17549667
41. ATOH1 activates hairy and enhancer of split 6 transcription through binding to three clustered E boxes of its promoter PMID: 17826772
42. Hath1 protein degradation may be required for maintaining the undifferentiated state of colon cancers, and that GSK3 inhibitors have potential for use in cancer therapy. PMID: 18275842
43. Our data indicate that ATOH1 may be an early target for oncogenic mutations in tissues where it instructs cellular differentiation. PMID: 19243219
44. Adult Atoh1-conditional knock-out mice are behaviorally deaf, have diminished auditory brainstem responses and disrupted auditory nuclei morphology. PMID: 19741118
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亞細胞定位：

Nucleus.
數據庫鏈接：

HGNC: 797

OMIM: 601461

KEGG: hsa:474

STRING: 9606.ENSP00000302216

UniGene: Hs.532680