Recombinant Human Protein NPAT (NPAT), partial

中文名稱：

人NPAT重組蛋白
貨號：

CSB-YP621766HU
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

人NPAT重組蛋白
貨號：

CSB-EP621766HU
說明書：

MSDS Datasheet
規格：
來源：

E.coli
其他：

中文名稱：

人NPAT重組蛋白
貨號：

CSB-EP621766HU-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

人NPAT重組蛋白
貨號：

CSB-BP621766HU
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：

人NPAT重組蛋白
貨號：

CSB-MP621766HU
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

NPAT
Uniprot No.：

Q14207
別名：

NPAT; CAND3; E14; Protein NPAT; Nuclear protein of the ataxia telangiectasia mutated locus; Nuclear protein of the ATM locus; p220
種屬：

Homo sapiens (Human)
蛋白長度：

Partial
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Required for progression through the G1 and S phases of the cell cycle and for S phase entry. Activates transcription of the histone H2A, histone H2B, histone H3 and histone H4 genes in conjunction with MIZF. Also positively regulates the ATM, MIZF and PRKDC promoters. Transcriptional activation may be accomplished at least in part by the recruitment of the NuA4 histone acetyltransferase (HAT) complex to target gene promoters.
基因功能參考文獻：
1. Cpn10 has a role in the spatial regulation of NPAT signaling PMID: 26429916
2. The conserved C-terminal domain shared by FLASH, YARP, and Mute recognizes the C-terminal sequence of NPAT orthologues, thus acting as a signal targeting proteins to histone locus bodies. PMID: 25339177
3. Genetic variants of NPAT-ATM and AURKA are associated with an individual early adverse reaction in the gastrointestinal tract of patients with cervical cancer treated with pelvic radiation therapy PMID: 21050672
4. NPAT is thus far the first gene implicated in nodular lymphocyte predominant Hodgkin lymphoma predisposition. PMID: 21562039
5. NPAT is essential for histone mRNA 3' end processing and recruits CDK9 to replication-dependent histone genes. PMID: 20190802
6. Results characterize the functional signals required for NPAT localization to the cell nucleus. PMID: 12473189
7. NPAT links E2F to the activation of S-phase-specific histone gene transcription. PMID: 12665581
8. the ability of p220 to promote S phase is independent of its ability to promote histone H4 transcription and p220 may link cyclin E/Cdk2 to multiple independent downstream functions PMID: 12724424
9. OCA-S, the multicomponent Oct-1 coactivator, intercts with NPAT. PMID: 12887926
10. p220 is an essential downstream component of the cyclin E/Cdk2 signaling pathway and functions to coordinate multiple elements of the G1/S transition. PMID: 14612403
11. NPAT, together with CUL5 and PPP2R1B, is implicated in the deregulation of the cell-cycle and apoptosis regulators and in the pathogenesis of B-CLL. PMID: 17449237
12. NPAT recruits the TRRAP-Tip60 complex to histone gene promoters to coordinate the transcriptional activation of multiple histone genes during the G(1)/S-phase transition PMID: 17967892
13. HiNF-P/P220NPAT regulates expression of nonhistone targets that influence competency for cell cycle progression. PMID: 17974976
14. Only the number of FLASH/NPAT histone gene locus bodies correlates with ploidy and only these organelles appear to be regulated during the cell cycle. PMID: 18677100
15. Results suggest that cyclin-dependent kinase inhibitors selectively control stimulation of the histone H4 gene promoter by the p220(NPAT)/HiNF-P complex. PMID: 19170105
16. The subnuclear organization of histone gene regulatory proteins and 3' end processing factors (NPAT/LSM10) of normal somatic and embryonic stem cells is compromised in selected human cancer cell types. PMID: 19277982
17. Cyclin D2 and the CDK substrate p220(NPAT) are required for self-renewal of human embryonic stem cells. PMID: 19890848
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亞細胞定位：

Nucleus. Nucleus, Cajal body. Note=Concentrates in two Cajal bodies tethered to histone gene clusters at chromosome 6p21 during G1, S and G2 phases. Also concentrates in two additional Cajal bodies tethered to histone gene clusters at chromosome 1q21 specifically during S and G2 phases.
蛋白家族：

NPAT family
組織特異性：

Ubiquitously expressed.
數據庫鏈接：

HGNC: 7896

OMIM: 601448

KEGG: hsa:4863

STRING: 9606.ENSP00000278612

UniGene: Hs.171061