Recombinant Human Potassium voltage-gated channel subfamily H member 5 (KCNH5), partial

中文名稱：

人KCNH5重組蛋白
貨號：

CSB-YP839852HU
說明書：

MSDS Datasheet
規(guī)格：
來源：

Yeast
其他：

中文名稱：

人KCNH5重組蛋白
貨號：

CSB-EP839852HU
說明書：

MSDS Datasheet
規(guī)格：
來源：

E.coli
其他：

中文名稱：

人KCNH5重組蛋白
貨號：

CSB-EP839852HU-B
說明書：

MSDS Datasheet
規(guī)格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

人KCNH5重組蛋白
貨號：

CSB-BP839852HU
說明書：

MSDS Datasheet
規(guī)格：
來源：

Baculovirus
其他：

中文名稱：

人KCNH5重組蛋白
貨號：

CSB-MP839852HU
說明書：

MSDS Datasheet
規(guī)格：
來源：

Mammalian cell
其他：

產(chǎn)品詳情
產(chǎn)品評價
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靶點詳情

產(chǎn)品詳情

純度：

>85% (SDS-PAGE)
基因名：

KCNH5
Uniprot No.：

Q8NCM2
別名：

KCNH5; EAG2Potassium voltage-gated channel subfamily H member 5; Ether-a-go-go potassium channel 2; hEAG2; Voltage-gated potassium channel subunit Kv10.2
種屬：

Homo sapiens (Human)
蛋白長度：

Partial
蛋白標(biāo)簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產(chǎn)品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復(fù)溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質(zhì)期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產(chǎn)品評價

靶點詳情

功能：

Pore-forming (alpha) subunit of voltage-gated potassium channel. Elicits a non-inactivating outward rectifying current. Channel properties may be modulated by cAMP and subunit assembly.
基因功能參考文獻：
1. EAG2 potassium channel has an evolutionarily conserved function for promoting brain tumor growth. PMID: 26258683
2. The observed Ca(2+)-induced proteolytic cleavage of EAG2 channel may act as an adaptive response under physiological and/or pathological conditions. PMID: 25542181
3. Study propose that hypomethylation of the placental-specific KCNH5 promoter is frequently associated with KCNH5 expression in melanoma cells. PMID: 24759919
4. Our results demonstrate the critical role of the Arg327 residue in stabilizing the channel closed state and explicate for the first time the structural and functional change of a Kv10.2 channel mutation associated with neurological disease. PMID: 24133262
5. This study performed whole exome sequencing demonistrated that the true de novo variants represent mutations in genes (KCNH5, CLCN4, and ARHGEF15) not previously associated with epilepsies in humans. PMID: 23647072
6. Three-dimensional structure of human Kv10.2 ion channel studied by single particle electron microscopy and molecular modeling PMID: 22792721
7. molecular identification and characterisation PMID: 12135768
8. Methylation of KCNH5 was present in 80% of NSCLC tissues but only in 14% of noncancerous tissues. PMID: 18349282
9. data suggest that the 'Per-Ant-Sim' (PAS) and cyclic nucleotide binding (cNBD) domains at the N- and C-termini form interacting oligomers that have roles in channel function PMID: 19172261
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亞細(xì)胞定位：

Membrane; Multi-pass membrane protein.
蛋白家族：

Potassium channel family, H (Eag) (TC 1.A.1.20) subfamily, Kv10.2/KCNH5 sub-subfamily
組織特異性：

Detected in brain, skeletal muscle, heart, placenta, lung and liver, and at low levels in kidney.
數(shù)據(jù)庫鏈接：

HGNC: 6254

OMIM: 605716

KEGG: hsa:27133

STRING: 9606.ENSP00000321427

UniGene: Hs.27043