Recombinant Human Phosphatidate phosphatase LPIN2 (LPIN2), partial

中文名稱：

人LPIN2重組蛋白
貨號：

CSB-YP838780HU
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

人LPIN2重組蛋白
貨號：

CSB-EP838780HU
說明書：

MSDS Datasheet
規格：
來源：

E.coli
其他：

中文名稱：

人LPIN2重組蛋白
貨號：

CSB-EP838780HU-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

人LPIN2重組蛋白
貨號：

CSB-BP838780HU
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：

人LPIN2重組蛋白
貨號：

CSB-MP838780HU
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

LPIN2
Uniprot No.：

Q92539
別名：

KIAA0249; Lipin-2; Lipin2; LPIN 2; LPIN2; LPIN2_HUMAN; OTTHUMP00000162242; Phosphatidate phosphatase LPIN2
種屬：

Homo sapiens (Human)
蛋白長度：

Partial
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Acts as a magnesium-dependent phosphatidate phosphatase enzyme which catalyzes the conversion of phosphatidic acid to diacylglycerol during triglyceride, phosphatidylcholine and phosphatidylethanolamine biosynthesis in the reticulum endoplasmic membrane. Plays important roles in controlling the metabolism of fatty acids at different levels. Acts also as a nuclear transcriptional coactivator for PPARGC1A to modulate lipid metabolism.
基因功能參考文獻：
1. Structural variants unique to the malignant cell line inactivated: LPIN2, a phosphatidic acid phosphatase and a co-factor of PGC1a that is important for lipid metabolism and for suppressing autoinflammation. PMID: 23792589
2. We describe two brothers with Majeed syndrome, homozygous novel 2-base pair deletion in LPIN2 (c.1312_1313delCT; p.Leu438fs+16X) PMID: 23087183
3. LPIN1-related myolysis constitutes a major cause of early-onset rhabdomyolysis and occasionally in adults. Heterozygous LPIN1 mutations may cause mild muscular symptoms. No major defects of LPIN2 or LPIN3 genes were associated with muscle manifestations. PMID: 22481384
4. role of lipin-2 in the proinflammatory action of saturated fatty acids in murine and human macrophages PMID: 22334674
5. Data revealed that lipin 1 formed stable homo-oligomers with itself and hetero-oligomers with lipin 2/3. PMID: 20735359
6. LPIN2 gene was excluded as a candidate for myopia 2 (MYP2), but the SNPs detected in this study will aid in future mapping and association studies involving this gene. PMID: 15862761
7. We conclude that homozygous mutations in LPIN2 result in Majeed syndrome. Understanding the aberrant immune response in this condition will shed light on the aetiology of other inflammatory disorders of multifactorial aetiology PMID: 15994876
8. A single nucleotide polymorphism of the LPIN2 gene is associated with type 2 diabetes and fat distribution. PMID: 17804763
9. distinct and non-redundant functions of lipin 1 and 2 regulate lipid production during the cell cycle and adipocyte differentiation PMID: 18694939
10. lipin 2 plays an important role as a hepatic PAP-1 enzyme. PMID: 19136718
11. A conserved serine residue is required for the phosphatidate phosphatase activity but not the transcriptional coactivator functions of lipin-1 and lipin-2. PMID: 19717560
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相關疾病：

Majeed syndrome (MJDS)
亞細胞定位：

Nucleus. Cytoplasm, cytosol. Endoplasmic reticulum membrane.
蛋白家族：

Lipin family
組織特異性：

Expressed in liver, lung, kidney, placenta, spleen, thymus, lymph node, prostate, testes, small intestine, and colon.
數據庫鏈接：

HGNC: 14450

OMIM: 605519

KEGG: hsa:9663

STRING: 9606.ENSP00000261596

UniGene: Hs.132342