Recombinant Human Period circadian protein homolog 3 (PER3), partial
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中文名稱：人PER3重組蛋白
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貨號：CSB-EP017788HU-B
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說明書：
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規格：
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來源：E.coli
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共軛：Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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其他：
產品詳情
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純度：>85% (SDS-PAGE)
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基因名：PER3
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Uniprot No.：
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別名：2810049O06Rik ; Cell growth inhibiting gene 13 protein; Cell growth-inhibiting gene 13 protein; Circadian clock protein PERIOD 3; GIG13; gPER3; Growth inhibiting protein 13; HGNC:8847; hPER3; mPer3; Per3; PER3_HUMAN; Period 3; Period circadian clock 3; Period circadian protein 3; Period circadian protein homolog 3; Period homolog 3 (Drosophila); Period homolog 3; Period homolog 3; Drosophila; Period3
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種屬：Homo sapiens (Human)
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蛋白長度：Partial
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蛋白標簽：Tag?type?will?be?determined?during?the?manufacturing?process.
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially. -
產品提供形式：Lyophilized powder Warning: in_array() expects parameter 2 to be array, null given in /www/web/cusabio_cn/public_html/caches/caches_template/default/content/show_product_protein.php on line 662
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand. -
復溶：We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
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儲存條件：Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
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保質期：The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C. -
貨期：Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
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注意事項：Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
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Datasheet ：Please contact us to get it.
產品評價
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靶點詳情
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功能：Originally described as a core component of the circadian clock. The circadian clock, an internal time-keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in metabolism and behavior. It is derived from the Latin roots 'circa' (about) and 'diem' (day) and acts as an important regulator of a wide array of physiological functions including metabolism, sleep, body temperature, blood pressure, endocrine, immune, cardiovascular, and renal function. Consists of two major components: the central clock, residing in the suprachiasmatic nucleus (SCN) of the brain, and the peripheral clocks that are present in nearly every tissue and organ system. Both the central and peripheral clocks can be reset by environmental cues, also known as Zeitgebers (German for 'timegivers'). The predominant Zeitgeber for the central clock is light, which is sensed by retina and signals directly to the SCN. The central clock entrains the peripheral clocks through neuronal and hormonal signals, body temperature and feeding-related cues, aligning all clocks with the external light/dark cycle. Circadian rhythms allow an organism to achieve temporal homeostasis with its environment at the molecular level by regulating gene expression to create a peak of protein expression once every 24 hours to control when a particular physiological process is most active with respect to the solar day. Transcription and translation of core clock components (CLOCK, NPAS2, ARNTL/BMAL1, ARNTL2/BMAL2, PER1, PER2, PER3, CRY1 and CRY2) plays a critical role in rhythm generation, whereas delays imposed by post-translational modifications (PTMs) are important for determining the period (tau) of the rhythms (tau refers to the period of a rhythm and is the length, in time, of one complete cycle). A diurnal rhythm is synchronized with the day/night cycle, while the ultradian and infradian rhythms have a period shorter and longer than 24 hours, respectively. Disruptions in the circadian rhythms contribute to the pathology of cardiovascular diseases, cancer, metabolic syndromes and aging. A transcription/translation feedback loop (TTFL) forms the core of the molecular circadian clock mechanism. Transcription factors, CLOCK or NPAS2 and ARNTL/BMAL1 or ARNTL2/BMAL2, form the positive limb of the feedback loop, act in the form of a heterodimer and activate the transcription of core clock genes and clock-controlled genes (involved in key metabolic processes), harboring E-box elements (5'-CACGTG-3') within their promoters. The core clock genes: PER1/2/3 and CRY1/2 which are transcriptional repressors form the negative limb of the feedback loop and interact with the CLOCK|NPAS2-ARNTL/BMAL1|ARNTL2/BMAL2 heterodimer inhibiting its activity and thereby negatively regulating their own expression. This heterodimer also activates nuclear receptors NR1D1, NR1D2, RORA, RORB and RORG, which form a second feedback loop and which activate and repress ARNTL/BMAL1 transcription, respectively. Has a redundant role with the other PER proteins PER1 and PER2 and is not essential for the circadian rhythms maintenance. In contrast, plays an important role in sleep-wake timing and sleep homeostasis probably through the transcriptional regulation of sleep homeostasis-related genes, without influencing circadian parameters. Can bind heme.
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基因功能參考文獻：
- Study identified several CpG sites and specifically several CpGs in the PTPRS and PER3 genes differentially methylated between obese and non-obese children, suggesting a role for DNA methylation concerning development of childhood obesity. PMID: 28614626
- these findings suggest that rhythmic expression of the circadian clock gene PER3 is associated with the amount of daily physical activity and physical fitness in older adults PMID: 28045078
- PER3 polymorphisms links with chronotype and affective dimensions PMID: 28708003
- data suggest that, PER3(4/4) genotype may accelerate the course of disease in multiple sclerosis susceptible individuals especially in women PMID: 29055480
- The impact of PER3 polymorphisms on sleep cycle and insomnia in older adults is reported. PMID: 28276850
- there is a significant association between the PER3 polymorphism and the extraversion personality trait PMID: 28055273
- PER34/4 genotype may accelerate the course of disease in multiple sclerosis susceptible individuals. PMID: 29055479
- CLOCK rs1801260*C and PER3(4/4) influence myelination processes by regulating sleep quality and quantity. PMID: 27996307
- 4 and 5 variable-number tandem-repeat polymorphisms appear to influence sensitivity to the effects of stressful urban environments on sleep PMID: 27593530
- Data suggest that three E box-like response elements are located upstream of PER3 transcription start sites; these response elements appear to additively contribute to cell-autonomous transcriptional oscillation of PER3 and other circadian proteins. PMID: 28821614
- This study showed that Lack of Association between Genetic Polymorphism of PER3 gene with Late Onset Depression and Alzheimer's Disease in a Sample of a Brazilian Population PMID: 27335043
- This study shown a possible association between Per3 polymorphism and consciousness recovery level in Disorders of Consciousness patients. PMID: 26359345
- PER3 variants may be associated with decreased risk for depressive symptoms, including subthreshold levels of depressive symptoms, in older adults. PMID: 25892098
- The PER1 c.2884C > G polymorphism and PER3 54bp VNTR were associated with annual percent changes in bone mineral density of femoral neck after 1 year of hormone therapy. PMID: 26624862
- PER3 polymorphism is associated with sleep quality after a mild traumatic brain injury. PMID: 26440425
- PER3 VNTR polymorphism influences both response to antidepressant chronotherapeutics and total sleep time after the repeated sleep deprivation treatment in patients with bipolar depression. PMID: 26707349
- No association between cluster headache, PER3 VNTR polymorphism and chronotype was found in this study. PMID: 26922944
- There was no significant association between the PER3 VNTR polymorphism and the irregularity of the menstrual cycle in Korean adolescents. PMID: 26453284
- A role for PER3 in modulating circadian clock and mood during seasonal changes PMID: 26903630
- This work suggests a role of PER3 rs10462020 in predicting a prognosis in Diffuse large B-cell lymphoma overall survival of patients. PMID: 26406960
- evidence of an association between PER3 gene and planning performance in a sample of healthy subjects PMID: 25798540
- PER3 VNTR genotype does not explain the difference in chronotype between South African and Dutch marathon runners PMID: 26102236
- minor polymorphisms of PER3 may be associated with poor morning gastric motility, and may have a combinatorial effect with CLOCK. PMID: 25775462
- The findings support the notion that PER3 polymorphisms could be a potential genetic marker for an individual's circadian and sleep phenotypes. PMID: 25201053
- PER3 long allele carriers were more vulnerable to sleep-loss associated attentional lapses than those with the short allele. PMID: 25940842
- length polymorphism in the Period 3 gene is associated with sleepiness and maladaptive circadian phase in night-shift workers PMID: 25545397
- In patients with non-small cell lung cancer, those with lower expression of Per1, Per2 and Per3 had a shorter survival time than those with higher expression. PMID: 25550826
- PERIOD3 clock gene length polymorphism may have a role in colorectal adenoma formation PMID: 25501848
- The data indicate that humans homozygous for the PER3(5/5) allele are more sensitive to NIF light effects, as indexed by specific changes in sleep EEG activity. PMID: 24893318
- no evidence supporting a global association of PER3 genetic variants with the incidence of cancer (Meta-Analysis) PMID: 25837749
- The polymorphisms studied in PER3 did not demonstrate any relationship with Bone Mineral Density or the odds of osteoporosis in postmenopausal Korean women. PMID: 24678593
- Provide some evidence that circadian rhythm of flight cadets with the PER3 (5) allele are less likely to be affected compared to those with the PER3 (4) allele. PMID: 25400784
- A wild genotype of rs228729 in PER3 was the primary risk factor contributing to Chinese hepatocellular carcinoma patients recurrence-free survival. PMID: 25344870
- An association is outlined of Per3 five repeat allele with T2DM occurrence and suggest that individuals with five repeat allele may be at a greater risk for T2DM as compared to those carrying the four repeat allele. PMID: 25390010
- PER3, at least partially, was targeted by miRNA-103, which might affect cells apoptosis in G2/M phase by modulating apoptosis-related gene in p53 pathway. PMID: 24393525
- Per3 VNTR may contribute to modulation of cardiac functions and interindividual differences in development and progression of myocardial infarction PMID: 24866331
- Per3 variable number tandem repeat polymorphism is not a major risk factor for chronic heart failure (CHF) or a factor modulating the severity of the CHF in this population. PMID: 23128810
- there is significant association between diurnal preference and a polymorphism in PER3 and a novel nominally significant association between diurnal preference and a polymorphism in ARNTL2 PMID: 24635757
- Five SNPs (rs228727, rs228644, rs228729, rs707467, rs104620202) in the period 3 (PER3) gene are significant correlation with genotype and allele frequency in lung cancer. PMID: 24821610
- No association with SNPs or haplotypes of the PER3 gene was observed in prophylactic lithium response. PMID: 24636202
- there is a greater detrimental impact of sleep deprivation in PER3(5/5) than PER3(4/4) carriers. the group with greater attentional performance impairment due to sleep deprivation (PER3(5/5) carriers) is superior at initiating sleep over the 24-h cycle. PMID: 24439663
- Women with the 4/5 or 5/5 PER3 genotype had a nonstatistically significant 33% increased odds of breast cancer. PMID: 24903750
- PER3 genotype predicted circadian rhythm period lengthening by lithium, specifically among bipolar disorder cases. PMID: 24150227
- the association of rs934945 with "morning alertness" and rs2640909 with "morningness". PMID: 23969301
- there is significant daily variation in PER2, PER3, and ARNTL1 expression with earlier timing of expression in women than in men PMID: 23606611
- polymorphisms more behaviorally salient with increasing severity and/or duration of sleep restriction PMID: 23171222
- These data document for the first time that the expression of BMAL1, PER3, PPARD and CRY2 genes is altered in gestational diabetes compared to normal pregnant women. deranged expression of clock genes may play a pathogenic role in GDM. PMID: 23323702
- Studies indicate that in the cytoplasm, PER3 protein heterodimerizes with PER1, PER2, CRY1, and CRY2 proteins and enters into the nucleus, resulting in repression of CLOCK-BMAL1-mediated transcription. PMID: 23546644
- Cortisol secretion was modified among police officers with different PER3 VNTR clock gene variants. PMID: 23524621
- the association study of the 54-nucleotide repeat in exon 18 of the hPer3 gene with a predisposition to opioid dependence among residents of the West Siberian region of Russia PMID: 22976125
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相關疾病：Advanced sleep phase syndrome, familial, 3 (FASPS3)
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亞細胞定位：Cytoplasm. Nucleus.
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