Recombinant Human Neurabin-2 (PPP1R9B), partial

中文名稱：

人PPP1R9B重組蛋白
貨號(hào)：

CSB-YP839413HU
說(shuō)明書(shū)：

MSDS Datasheet
規(guī)格：
來(lái)源：

Yeast
其他：

中文名稱：

人PPP1R9B重組蛋白
貨號(hào)：

CSB-EP839413HU
說(shuō)明書(shū)：

MSDS Datasheet
規(guī)格：
來(lái)源：

E.coli
其他：

中文名稱：

人PPP1R9B重組蛋白
貨號(hào)：

CSB-EP839413HU-B
說(shuō)明書(shū)：

MSDS Datasheet
規(guī)格：
來(lái)源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

人PPP1R9B重組蛋白
貨號(hào)：

CSB-BP839413HU
說(shuō)明書(shū)：

MSDS Datasheet
規(guī)格：
來(lái)源：

Baculovirus
其他：

中文名稱：

人PPP1R9B重組蛋白
貨號(hào)：

CSB-MP839413HU
說(shuō)明書(shū)：

MSDS Datasheet
規(guī)格：
來(lái)源：

Mammalian cell
其他：

產(chǎn)品詳情
產(chǎn)品評(píng)價(jià)
相關(guān)產(chǎn)品
靶點(diǎn)詳情

產(chǎn)品詳情

純度：

>85% (SDS-PAGE)
基因名：

PPP1R9B
Uniprot No.：

Q96SB3
別名：

FLJ30345; NEB2_HUMAN; Neurabin II; Neurabin-2; Neurabin-II; Neurabin2; NeurabinII; Neural tissue specific F actin binding protein II; p130; PP1bp134; PPP1R6; PPP1R9; Ppp1r9b; Protein phosphatase 1 regulatory subunit 9B; SPINO; Spinophilin
種屬：

Homo sapiens (Human)
蛋白長(zhǎng)度：

Partial
蛋白標(biāo)簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產(chǎn)品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復(fù)溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲(chǔ)存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質(zhì)期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項(xiàng)：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

功能：

Seems to act as a scaffold protein in multiple signaling pathways. Modulates excitatory synaptic transmission and dendritic spine morphology. Binds to actin filaments (F-actin) and shows cross-linking activity. Binds along the sides of the F-actin. May play an important role in linking the actin cytoskeleton to the plasma membrane at the synaptic junction. Believed to target protein phosphatase 1/PP1 to dendritic spines, which are rich in F-actin, and regulates its specificity toward ion channels and other substrates, such as AMPA-type and NMDA-type glutamate receptors. Plays a role in regulation of G-protein coupled receptor signaling, including dopamine D2 receptors and alpha-adrenergic receptors. May establish a signaling complex for dopaminergic neurotransmission through D2 receptors by linking receptors downstream signaling molecules and the actin cytoskeleton. Binds to ADRA1B and RGS2 and mediates regulation of ADRA1B signaling. May confer to Rac signaling specificity by binding to both, RacGEFs and Rac effector proteins. Probably regulates p70 S6 kinase activity by forming a complex with TIAM1. Required for hepatocyte growth factor (HGF)-induced cell migration.
基因功能參考文獻(xiàn)：
1. Study determined that spinophilin binding to neurofilament medium required overexpression of the catalytic subunit of protein kinase A and was decreased by cyclin-dependent protein kinase 5. PMID: 28634551
2. Clinical onset of AD is marked by the loss of PreC spinophilin-ir dendritic spines that is related to Abeta pathology and may contribute to cognitive symptoms early in the disease. PMID: 28259365
3. The increased cancer stem cells-like properties induced by the downregulation of Spn might account for the increased malignant phenotype observed in Spn-null breast tumors. PMID: 26387546
4. homo-oligomerization of neurabin is required for stabilizing RGS4 on the plasma membrane to attenuate A1R signaling PMID: 28954816
5. Data identify Spn as a critical adhesion and signaling protein that is essential for modulating glioblastoma cell invasion in the brain microenvironment. Spn suppresses brain tumor cell invasion, in part, via control of Rac1 GTPase activities and invadopodia disassembly. Its C-terminus binds directly to the beta 8 integrin cytoplasmic tail. PMID: 27655131
6. results indicate that spinophilin plays an important role in regulating the activity of Group I mGluRs as well as their influence on synaptic activity. PMID: 27358397
7. Low spinophilin expression enhances aggressive biological behavior of breast cancer. PMID: 25857299
8. Colorectal carcinoma expression of spinophilin expression determines cellular growth, cancer stemness and 5-flourouracil resistance. PMID: 25261368
9. spinophilin might play a previously unrecognized role in the pathogenesis of head and neck squamous cell carcinoma PMID: 24565202
10. Spn downregulation contributes to a more aggressive biologic behavior, induces chemoresistance, and is associated with a poorer survival in patients with advanced stages of colorectal carcinoma. PMID: 23729363
11. study found a substantial number of hepatocellular carcinomas (HCC) show reduced or absent Spn expression; the low expression of Spn in tumour tissue is an independent negative prognostic factor for clinical outcome in HCC; spinophilin expression inversely correlates with proliferative activity PMID: 23591196
12. Spinophilin associates with both delta- and mu-OmicronR and G protein subunits in HEK293 cells participating in a multimeric signaling complex that displays a differential regulatory role in opioid receptor signaling. PMID: 22922354
13. Spinophilin-deficient mice have enhanced antidepressant response to desipramine compared with wild-type controls. PMID: 22369787
14. The molecular size and subcellular location of myotube glycogen particles is determined by the PPP1R6, PTG and G(M) scaffolding. PMID: 22054094
15. IRSp53 and spinophilin regulate localized Rac activation by T-lymphocyte invasion and metastasis protein 1 PMID: 20360004
16. The actin-binding domain of spinophilin is necessary and sufficient for targeting of spinophilin to dendrites and dendritic spines. PMID: 12230305
17. Decreased spinophilin but unchanged MAP2 expression provides molecular evidence for a hippocampal dendritic pathology in schizophrenia that preferentially affects the spines. PMID: 15465982
18. PPP1R9B is required for synapse formation in the NK cells and suggest that it may be involved in the maintenance of cellular architecture by regulation of actin assembly, possibly acting to stabilize the NKIS until granule release is eminent. PMID: 19130477
19. Asef2, Neurabin2 and APC cooperatively regulate actin cytoskeletal organization and are required for HGF-induced cell migration. PMID: 19151759
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亞細(xì)胞定位：

Cytoplasm, cytoskeleton. Nucleus. Cell projection, dendritic spine. Cell junction, synapse, postsynaptic density. Cell junction, synapse. Cell junction, adherens junction. Cytoplasm. Cell membrane. Cell projection, lamellipodium. Cell projection, filopodium. Cell projection, ruffle membrane.
數(shù)據(jù)庫(kù)鏈接：

HGNC: 9298

OMIM: 603325

KEGG: hsa:84687

UniGene: Hs.514323