Recombinant Human NACHT, LRR and PYD domains-containing protein 10 (NLRP10)

中文名稱：

人NLRP10重組蛋白
貨號：

CSB-YP773044HU
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

人NLRP10重組蛋白
貨號：

CSB-EP773044HU
說明書：

MSDS Datasheet
規格：
來源：

E.coli
其他：

中文名稱：

人NLRP10重組蛋白
貨號：

CSB-EP773044HU-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

人NLRP10重組蛋白
貨號：

CSB-BP773044HU
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：

人NLRP10重組蛋白
貨號：

CSB-MP773044HU
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
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靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

NLRP10
Uniprot No.：

Q86W26
別名：

CLR11.1; NACHT, leucine rich repeat and PYD containing 10; NACHT, LRR and PYD domains containing protein 10; NACHT, LRR and PYD domains-containing protein 10; NAL10_HUMAN; NALP10; NLR family, pyrin domain containing 10; Nlrp10; NOD8; Nucleotide-binding oligomerization domain protein 8; Nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing 10; PAN5; PYNOD
種屬：

Homo sapiens (Human)
蛋白長度：

full length protein
表達區域：

1-655
氨基酸序列

MAMAKARKPR EALLWALSDL EENDFKKLKF YLRDMTLSEG QPPLARGELE GLIPVDLAEL LISKYGEKEA VKVVLKGLKV MNLLELVDQL SHICLHDYRE VYREHVRCLE EWQEAGVNGR YNQVLLVAKP SSESPESLAC PFPEQELESV TVEALFDSGE KPSLAPSLVV LQGSAGTGKT TLARKMVLDW ATGTLYPGRF DYVFYVSCKE VVLLLESKLE QLLFWCCGDN QAPVTEILRQ PERLLFILDG FDELQRPFEE KLKKRGLSPK ESLLHLLIRR HTLPTCSLLI TTRPLALRNL EPLLKQARHV HILGFSEEER ARYFSSYFTD EKQADRAFDI VQKNDILYKA CQVPGICWVV CSWLQGQMER GKVVLETPRN STDIFMAYVS TFLPPDDDGG CSELSRHRVL RSLCSLAAEG IQHQRFLFEE AELRKHNLDG PRLAAFLSSN DYQLGLAIKK FYSFRHISFQ DFFHAMSYLV KEDQSRLGKE SRREVQRLLE VKEQEGNDEM TLTMQFLLDI SKKDSFSNLE LKFCFRISPC LAQDLKHFKE QMESMKHNRT WDLEFSLYEA KIKNLVKGIQ MNNVSFKIKH SNEKKSQSQN LFSVKSSLSH GPKEEQKCPS VHGQKEGKDN IAGTQKEAST GKGRGTEETP KNTYI
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder Warning: in_array() expects parameter 2 to be array, null given in /www/web/cusabio_cn/public_html/caches/caches_template/default/content/show_product_protein.php on line 662
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Inhibits autoprocessing of CASP1, CASP1-dependent IL1B secretion, PYCARD aggregation and PYCARD-mediated apoptosis but not apoptosis induced by FAS or BID. Displays anti-inflammatory activity. Required for immunity against C.albicans infection. Involved in the innate immune response by contributing to proinflammatory cytokine release in response to invasive bacterial infection. Contributes to T-cell-mediated inflammatory responses in the skin. Plays a role in protection against periodontitis through its involvement in induction of IL1A via ERK activation in oral epithelial cells infected with periodontal pathogens. Exhibits both ATPase and GTPase activities.
基因功能參考文獻：
1. Authors observed an important role of NLRP10 in cytokine and chemokine production as well as expression of NF-kappaB and MAPKs in CSE-exposed A549 cells. Furthermore, replenishment of A549 cell culture with recombinant IL-17A (rIL-17A) during NLRP10 knockdown rescued CSE-induced inflammatory responses. PMID: 29501574
2. these data suggest that NLRP10 is involved in activating the ERK signalling pathway in oral epithelial cell line infected with Tannerella forsythia and Fusobacterium nucleatum PMID: 28766990
3. Review summarize recent advances of the role of of human and murine NLRP10 in innate and adaptive immune responses. [Review] PMID: 23562614
4. These data revealed a novel role of NLRP10 in innate immune responses towards bacterial infection and suggest that NLRP10 functions as a scaffold for the formation of the NOD1-Nodosome. PMID: 22672233
5. The results show that either deletion of the p53 binding elements within the PYNOD promoter or treatment with p53 inhibitor could significantly reduce PYNOD promoter activity. PMID: 22365966
6. Transgenic PYNOD colocalizes with apoptosis-associated speck-like protein containing a caspase recruitment domain (ASC) and inhibits caspase-1-mediated interleukin (IL)-1beta processing without inhibiting caspase-4-mediated caspase-1 processing. PMID: 20393137
7. Observational study of gene-disease association. (HuGE Navigator) PMID: 20403135
8. PYNOD is a novel regulator of apoptosis and inflammation. PMID: 15096476
9. PYPAF3 is a feedback regulator of interleukin-1beta secretion, and PYPAF2 and PYPAF3, together with PYNOD, constitute an anti-inflammatory subgroup of PYRIN-containing apoptotic protease-activating factor-1-like proteins PMID: 15817483
10. The structural modification of the NLRP10 gene might have played a role in development or enhancement of human-specific traits during evolution. PMID: 19544093
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亞細胞定位：

Cytoplasm. Cell membrane; Peripheral membrane protein.
蛋白家族：

NLRP family
組織特異性：

Highly expressed in basal and suprabasal epidermal cell layers with lower levels in dermal fibroblast cells (at protein level). Widely expressed with highest levels in heart, brain and skeletal muscle. Also expressed in liver, colon, dermis and epidermis.
數據庫鏈接：

HGNC: 21464

OMIM: 609662

KEGG: hsa:338322

STRING: 9606.ENSP00000327763

UniGene: Hs.449636