Recombinant Human MYC-induced nuclear antigen (MINA)

中文名稱：

人RIOX2重組蛋白
貨號：

CSB-YP810267HU
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

人RIOX2重組蛋白
貨號：

CSB-EP810267HU
說明書：

MSDS Datasheet
規格：
來源：

E.coli
其他：

中文名稱：

人RIOX2重組蛋白
貨號：

CSB-EP810267HU-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

人RIOX2重組蛋白
貨號：

CSB-BP810267HU
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：

人RIOX2重組蛋白
貨號：

CSB-MP810267HU
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

RIOX2
Uniprot No.：

Q8IUF8
別名：

60S ribosomal protein L27a histidine hydroxylase; Bifunctional lysine specific demethylase and histidyl hydroxylase MINA; FLJ14393; Histone lysine demethylase MINA; MDIG; MINA; MINA_HUMAN; Mineral dust-induced gene protein; Myc induced nuclear antigen 53 kDa; MYC induced nuclear antigen; MYC-induced nuclear antigen; NO52; Nucleolar protein 52; Ribosomal oxygenase MINA; ROX
種屬：

Homo sapiens (Human)
蛋白長度：

full length protein
表達區域：

1-465
氨基酸序列

MPKKAKPTGS GKEEGPAPCK QMKLEAAGGP SALNFDSPSS LFESLISPIK TETFFKEFWE QKPLLIQRDD PALATYYGSL FKLTDLKSLC SRGMYYGRDV NVCRCVNGKK KVLNKDGKAH FLQLRKDFDQ KRATIQFHQP QRFKDELWRI QEKLECYFGS LVGSNVYITP AGSQGLPPHY DDVEVFILQL EGEKHWRLYH PTVPLAREYS VEAEERIGRP VHEFMLKPGD LLYFPRGTIH QADTPAGLAH STHVTISTYQ NNSWGDFLLD TISGLVFDTA KEDVELRTGI PRQLLLQVES TTVATRRLSG FLRTLADRLE GTKELLSSDM KKDFIMHRLP PYSAGDGAEL STPGGKLPRL DSVVRLQFKD HIVLTVLPDQ DQSDEAQEKM VYIYHSLKNS RETHMMGNEE ETEFHGLRFP LSHLDALKQI WNSPAISVKD LKLTTDEEKE SLVLSLWTEC LIQVV
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder Warning: in_array() expects parameter 2 to be array, null given in /www/web/cusabio_cn/public_html/caches/caches_template/default/content/show_product_protein.php on line 668
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Oxygenase that can act as both a histone lysine demethylase and a ribosomal histidine hydroxylase. Is involved in the demethylation of trimethylated 'Lys-9' on histone H3 (H3K9me3), leading to an increase in ribosomal RNA expression. Also catalyzes the hydroxylation of 60S ribosomal protein L27a on 'His-39'. May play an important role in cell growth and survival. May be involved in ribosome biogenesis, most likely during the assembly process of pre-ribosomal particles.
基因功能參考文獻：
1. RIOX2 transcripts were overexpressed in renal cell tumor subtypes compared to renal normal tissues. Higher RIOX2 transcript levels were associated with metastasis. PMID: 29099276
2. our findings revealed that Mina53 was an important indicator of prognosis in patients with stage III colorectal cancer treated with adjuvant chemotherapy. PMID: 29750310
3. Results indicate that mdig can inhibit the phosphorylation of GSK-3beta and promote the phosphorylation and destabilization of beta-catenin, in order to suppress the expression of slug, snail, and ZEB1 and the occurrence of EMT, and thereby inhibit the invasion and metastasis of non-small cell lung cancer (NSCLC). PMID: 29039479
4. mdig directly interacts with c-myc and JAK1 in multiple myeloma (MM) cell lines, which contributes to hyperactivation of the IL-6-JAK-STAT3 signaling important for the pathogenesis of MM. PMID: 27833099
5. MDIG overexpression substantially promoted hepatocellular carcinoma cell proliferation, cell migration and spreading, whereas knockdown of MDIG would reverse above-mentioned effect. PMID: 28471446
6. Findings reveal the role of MINA in glioblastoma initiation and progression by controlling the cell-cycle progression through transcriptionally regulating cyclin and CDK expression via the demethylation of H3K9me3. PMID: 27292258
7. Data suggest that mineral dust-induced gene protein (mdig) accomplishes its functions on chromatin, DNA repair and cell growth through interacting with the partner proteins. PMID: 26293673
8. in lung cancer tissues, upregulation of mdig expression accompanies with the downregulation of p27(KIP1) expression and in bronchial stump PMID: 25851349
9. Mina53 can be used as a marker for pancreatic cancer PMID: 24522517
10. Mina: a Th2 response regulator meets TGFbeta. PMID: 25282476
11. Increased expression of mdig in cancer tissues. PMID: 24505346
12. mina53 expression was gradually elevated during gastric carcinogenesis, and the overexpression of mina53 was correlated with different clinicopathological features between diffuse-type gastric carcinoma and intestinal-type gastric carcinoma cases. PMID: 24337011
13. Results imply that mdig is involved in the regulation of H3K9me3 to influence the heterochromatin structure of the genome and the expression of genes important for cell growth or transformation. PMID: 23965803
14. results show mdig induction by arsenic is partially dependent on the JNK and STAT3 signaling pathways. PMID: 24434654
15. these data suggest that an increased expression of mdig is an important prognostic factor for poorer survival time of the breast cancer patients. PMID: 24309373
16. The single nucleotide polymorphism of the Mina gene is associated with the development of asthma in Chinese Han children. PMID: 21631300
17. favorable prognostic marker in early stage lung cancer PMID: 19914733
18. Mina53 plays an important role in carcinogenesis and may be a target for cancer prevention. PMID: 19756735
19. role in cell division PMID: 12091391
20. the elevated expression of Mina53 is a characteristic feature in colon cancer PMID: 14695334
21. Mina53 may have a role in progression of esophageal squamous cell carcinoma PMID: 15534111
22. Data suggests NO52 protein (MYC induced nuclear antigen) is directly involved in ribosome biogenesis, most likely during the assembly process of preribosomal particles. PMID: 15819408
23. The expression of mineral dust induced mRNA was detected in alveolar macrophages from coal miners but not from normal subjects. PMID: 15897898
24. Increased expression of Mina53 is associated with lymphoma PMID: 17786344
25. Mina53 is overexpressed in renal cell carcinoma tissue from patients with poor prognostic factors, suggesting that Mina53 overexpression is one of the factors for poor prognosis in renal cell carcinoma. PMID: 17803656
26. Mina53 was overexpressed in gastric carcinoma and associated with tumor proliferation and antioncogene inactivation. PMID: 18629780
27. The MINA protein alters histone H3 methylation contributes to the initiation or development of the human lung cancer. PMID: 19502796
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亞細胞定位：

Nucleus. Nucleus, nucleolus.
蛋白家族：

ROX family, MINA53 subfamily
組織特異性：

Expressed in liver, skeletal muscle, heart, pancreas, and placenta. Not detected in brain, lung or kidney. Expressed in several lung cancer tissues, but is barely detected in the adjacent non-cancerous tissues. Also highly expressed in several esophageal
數據庫鏈接：

HGNC: 19441

OMIM: 612049

KEGG: hsa:84864

STRING: 9606.ENSP00000328251

UniGene: Hs.570562