Recombinant Human Leucine-rich repeat flightless-interacting protein 2 (LRRFIP2)

中文名稱：

人LRRFIP2重組蛋白
貨號：

CSB-YP896921HU
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

人LRRFIP2重組蛋白
貨號：

CSB-EP896921HU
說明書：

MSDS Datasheet
規格：
來源：

E.coli
其他：

中文名稱：

人LRRFIP2重組蛋白
貨號：

CSB-EP896921HU-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

人LRRFIP2重組蛋白
貨號：

CSB-BP896921HU
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：

人LRRFIP2重組蛋白
貨號：

CSB-MP896921HU
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

LRRFIP2
Uniprot No.：

Q9Y608
別名：

5133400F20Rik; AI850587; DKFZp434H2035; FLJ20248; FLJ22683; FLJ58304; HUFI 2; Leucine rich repeat (in FLII) interacting protein 2; Leucine rich repeat flightless interacting protein 2; Leucine-rich repeat flightless-interacting protein 2; LRR FLII interacting protein 2; LRR FLII-interacting protein 2; LRRF2_HUMAN; Lrrfip2
種屬：

Homo sapiens (Human)
蛋白長度：

full length protein
表達區域：

1-721
氨基酸序列

MGTPASGRKR TPVKDRFSAE DEALSNIARE AEARLAAKRA ARAEARDIRM RELERQQKEY SLHSFDRKWG QIQKWLEDSE RARYSHRSSH HRPYLGVEDA LSIRSVGSHR YDMFKDRSSR LSSLNHSYSH SHGMKKRSSD SHKDLLSGLY FDQRNYSSLR HSKPTSAYYT RQSSSLYSDP LATYKSDRAS PTANSGLLRS ASLASLYNGG LYNPYGPRTP SECSYYSSRI SSARSSPGFT NDDTASIVSS DRASRGRRES VVSAADYFSR SNRRGSVVSE VDDISIPDLS SLDEKSDKQY AENYTRPSSR NSASATTPLS GNSSRRGSGD TSSLIDPDTS LSELRDIYDL KDQIQDVEGR YMQGLKELKE SLSEVEEKYK KAMVSNAQLD NEKNNLIYQV DTLKDVIEEQ EEQMAEFYRE NEEKSKELER QKHMCSVLQH KMEELKEGLR QRDELIEEKQ RMQQKIDTMT KEVFDLQETL LWKDKKIGAL EKQKEYIACL RNERDMLREE LADLQETVKT GEKHGLVIIP DGTPNGDVSH EPVAGAITVV SQEAAQVLES AGEGPLDVRL RKLAGEKEEL LSQIRKLKLQ LEEERQKCSR NDGTVGDLAG LQNGSDLQFI EMQRDANRQI SEYKFKLSKA EQDITTLEQS ISRLEGQVLR YKTAAENAEK VEDELKAEKR KLQRELRTAL DKIEEMEMTN SHLAKRLEKM KANRTALLAQ Q
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

May function as activator of the canonical Wnt signaling pathway, in association with DVL3, upstream of CTNNB1/beta-catenin. Positively regulates Toll-like receptor (TLR) signaling in response to agonist probably by competing with the negative FLII regulator for MYD88-binding.
基因功能參考文獻：
1. Data show that the ability of Ca(2+) to accentuate the activity of NLRP3 inflammasome is abrogated in Flightless-I (FliI) and leucine-rich repeat FliI-interaction protein 2 (LRRFIP2)-knockdown macrophages. PMID: 27431477
2. FATylation of LRRFIP2 occurs on two distinct sites, each being modified by a single FAT10 moiety. PMID: 23036196
3. A novel exonic rearrangement affecting MLH1 and the contiguous LRRFIP2 is a founder mutation in Portuguese Lynch syndrome families PMID: 21785361
4. Unambiguous characterization of site-specific phosphorylation of leucine-rich repeat Fli-I-interacting protein 2 (LRRFIP2) in Toll-like receptor 4 (TLR4)-mediated signaling. PMID: 21220426
5. These data suggest that LRRFIP2 plays an important role in transducing Wnt signals. PMID: 15677333
6. LRR-binding MyD88 interactor LRRFIP2 is a positive regulator of NF-kappa B activity and is also a positive regulator of cytokine production in lipopolysaccharide-stimulated macrophages, suggesting a functional role in TLR4-mediated inflammatory response. PMID: 19265123
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蛋白家族：

LRRFIP family
組織特異性：

Widely expressed, with highest levels in heart and skeletal muscle.
數據庫鏈接：

HGNC: 6703

OMIM: 614043

KEGG: hsa:9209

STRING: 9606.ENSP00000338727

UniGene: Hs.740522