Recombinant Human Leucine carboxyl methyltransferase 1 (LCMT1)

中文名稱：

人LCMT1重組蛋白
貨號：

CSB-YP012808HU
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

人LCMT1重組蛋白
貨號：

CSB-EP012808HU
說明書：

MSDS Datasheet
規格：
來源：

E.coli
其他：

中文名稱：

人LCMT1重組蛋白
貨號：

CSB-EP012808HU-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

人LCMT1重組蛋白
貨號：

CSB-BP012808HU
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：

人LCMT1重組蛋白
貨號：

CSB-MP012808HU
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

LCMT1
Uniprot No.：

Q9UIC8
別名：

[Phosphatase 2A protein]-leucine-carboxy methyltransferase 1; CGI 68; LCMT; LCMT1; LCMT1_HUMAN; Leucine carboxyl methyltransferase 1; PPMT1 ; Protein leucine O methyltransferase ; protein phosphatase methyltransferase 1; Protein-leucine O-methyltransferase
種屬：

Homo sapiens (Human)
蛋白長度：

full length protein
表達區域：

1-334
氨基酸序列

MATRQRESSI TSCCSTSSCD ADDEGVRGTC EDASLCKRFA VSIGYWHDPY IQHFVRLSKE RKAPEINRGY FARVHGVSQL IKAFLRKTEC HCQIVNLGAG MDTTFWRLKD EDLLPSKYFE VDFPMIVTRK LHSIKCKPPL SSPILELHSE DTLQMDGHIL DSKRYAVIGA DLRDLSELEE KLKKCNMNTQ LPTLLIAECV LVYMTPEQSA NLLKWAANSF ERAMFINYEQ VNMGDRFGQI MIENLRRRQC DLAGVETCKS LESQKERLLS NGWETASAVD MMELYNRLPR AEVSRIESLE FLDEMELLEQ LMRHYCLCWA TKGGNELGLK EITY
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Methylates the carboxyl group of the C-terminal leucine residue of protein phosphatase 2A catalytic subunits to form alpha-leucine ester residues.
基因功能參考文獻：
1. alterations in the membrane localization of PP2A and Tau following down-regulation of LCMT1 may lead to PP2A and Tau dysfunction in AD. PMID: 23943618
2. determined crystal structures of human LCMT-1 in isolation and in complex with PP2A stabilized by a cofactor mimic. The structures show that the LCMT-1 active-site pocket recognizes the carboxyl terminus of PP2A PMID: 21292165
3. X-ray crystal structure of human LCMT1 protein in complex with the cofactor S-adenosylmethionine (AdoMet) has been solved to a resolution of 2 A. PMID: 21206058
4. LCMT-1 is important for normal progression through mitosis and cell survival and is essential for embryonic development PMID: 17724024
蛋白家族：

Methyltransferase superfamily, LCMT family
數據庫鏈接：

HGNC: 17557

OMIM: 610286

KEGG: hsa:51451

STRING: 9606.ENSP00000382021

UniGene: Hs.337730