Recombinant Human Latent-transforming growth factor beta-binding protein 1 (LTBP1), partial
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中文名稱：人LTBP1重組蛋白
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貨號：CSB-EP623934HU-B
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說明書：
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規格：
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來源：E.coli
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共軛：Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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其他：
產品詳情
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純度：>85% (SDS-PAGE)
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基因名：
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Uniprot No.：
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別名：9430031G15Rik; 9830146M04; Latent transforming growth factor beta binding protein 1; Latent-transforming growth factor beta-binding protein 1; Latent-transforming growth factor beta-binding protein, isoform 1L; Latent-transforming growth factor beta-binding protein, isoform 1S; LBT1S; LTBP-1; Ltbp1; LTBP1_HUMAN; MGC163161; TGF-beta1-BP-1; Tgfb; Transforming growth factor beta-1-binding protein 1; Transforming growth factor beta-1-masking protein large subunit
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種屬：Homo sapiens (Human)
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蛋白長度：Partial
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蛋白標簽：Tag?type?will?be?determined?during?the?manufacturing?process.
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially. -
產品提供形式：Lyophilized powder Warning: in_array() expects parameter 2 to be array, null given in /www/web/cusabio_cn/public_html/caches/caches_template/default/content/show_product_protein.php on line 662
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand. -
復溶：We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
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儲存條件：Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
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保質期：The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C. -
貨期：Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
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注意事項：Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
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Datasheet ：Please contact us to get it.
產品評價
相關產品
靶點詳情
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功能：Key regulator of transforming growth factor beta (TGFB1, TGFB2 and TGFB3) that controls TGF-beta activation by maintaining it in a latent state during storage in extracellular space. Associates specifically via disulfide bonds with the Latency-associated peptide (LAP), which is the regulatory chain of TGF-beta, and regulates integrin-dependent activation of TGF-beta. Outcompeted by LRRC32/GARP for binding to LAP regulatory chain of TGF-beta.
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基因功能參考文獻：
- these results show peripheral blood levels of TGF beta are significantly increased in colorectal patients PMID: 29924680
- Compared with the control, miR-340 was significantly lower in the serum of hepatocellular carcinoma patients (p<0.01). miR-340 was lower in HCC tissues than in adjacent; however, DcR3, TGF-beta1 and Smad2 were higher. PMID: 29311025
- It is a protein that promotes renal fibrosis in diabetic nephropathy. PMID: 29549584
- The present study demonstrated that in human osteoarthritis fibroblastlike synoviocytes, TGF-beta signals via p-Smad2 and p-Smad1/5/8. Furthermore, it was demonstrated that LTBP-1 may modulate the activity of TGF-beta in human osteoarthritis fibroblastlike synoviocytes. PMID: 29257223
- LTBP1 anchors itself to FBN1 using two independent epitopes. PMID: 28669633
- Expression levels of TGF-beta1 and BMP-2 appeared to be delayed in nonunion patients which could play an important role in developing an early marker of fracture union condition and facilitate improved patient's management. PMID: 28331138
- All members of the tolloid family bind the N terminus of latent TGFb-binding protein-1, providing support for their role in TGFb signalling. PMID: 27391803
- Eosinophils enhance Wnt-5a, TGF-beta1, fibronectin, and collagen gene expression in airway smooth muscle cells and promote proliferation of these cells in asthma. PMID: 27297409
- LTBP-1 and LTBP-2 are involved in the keratinization of oral epithelium. PMID: 25858550
- LTBP-1 may be a promising biomarker for distinguishing early stage hepatocellular carcinoma from the chronic hepatitis B or liver cirrhosis patients. PMID: 26884881
- role in olive-pollen sensitization PMID: 25759826
- Significantly higher frequency of TT genotype of transforming growth factor-Beta 1 in asthma patients was found compared to controls. PMID: 25359706
- The aim of this study is to evaluate whether specific inhibition of c-Abl by siRNA can influence the transforming growth factor-beta1 (TGF-beta1)-induced fibrotic responses. PMID: 25527259
- Dental pulp stem cells suppress the proliferation of lymphocytes via transforming growth factor-beta1 PMID: 25605036
- LTBP-1 showed both an accumulation and a striking co-localization with Notch3-ECD deposits suggesting specific recruitment into aggregates in brain in CADASIL. PMID: 25190493
- This review concludes that TGF-beta1 29T/C polymorphism does not play a role in breast cancer susceptibility in overall or ethnicity-specific manner. PMID: 25374198
- LTBP-1 an extracellular matrix protein and key regulator of TGF-beta bioavailability is a novel HtrA1 target.Attenuation of TGF-beta signaling caused by a lack of HtrA1-mediated LTBP-1 processing as mechanism underlying CARASIL pathogenesis. PMID: 25369932
- Combination of EGF with TGF-beta1, but not EGF or TGF-beta1 alone, caused assembly of cells to a new two-dimensional structure, being characterized by dense aggregates connected by branches of few cells. PMID: 25529149
- There is an increasing anti-cancer protection with increased numbers of alleles associated with higher levels of TGF-beta1 and IL-4. PMID: 24164868
- The LTBP1 C-terminus adopts a flexible "knotted rope" structure, which may facilitate cell matrix interactions. PMID: 24489852
- these results suggested that the C allele could increase TGF-beta secretion which suppresses antitumour immune responses and may affect the Oral squamous cell carcinoma risk. PMID: 23442056
- The expression of TGF-beta1 is increased while the Smad7 expression is diminished in dendritic cell infiltration decrease in liver gastrointestinal cancer metastasis. PMID: 23998914
- The high incidence of intimal hyperplasia in patients with surgically repaired congenital heart disease (CHD) is correlated with TGF-beta1 expression and may contribute to the development of atherosclerotic coronary artery disease in CHD patients. PMID: 23395279
- High transforming Growth Factor beta1 expression is associated with myelofibrosis. PMID: 23462118
- Dysregulated expression of TWIST1, TGF-beta1 and SMAD3 mRNA observed in osteoarthritis bone is reflected in the functionality of the osteoblast when these cells are cultured ex vivo. PMID: 22820497
- Data show that plasma TGF-beta1 was elevated in the circulation of patients with brain tumors and that significant decreases in TGF-beta1 levels were observed after the removal of benign and malignant tumors. PMID: 22632886
- Increased generation of reactive oxygen species (ROS) and enhanced expression of NADPH oxidases were found to be associated with the TGF-beta1-induced autophagy. PMID: 22322529
- results suggest that the CC genotype of the TGF-beta1 gene increases the risk to develop LOAD and is also associated with depressive symptoms in AD. PMID: 21924590
- The expression of PAI-1 mRNA and TGF-beta1 mRNA was significantly higher in the cDNA samples obtained from the atopic cataracts than those obtained from the senile cataracts. PMID: 22410565
- susceptibility genes associated with alcohol drinking PMID: 22295116
- Elevated expression of either TGF-beta1 or TGF-beta2 in cells that represent the early stages in the development of human squamous cell carcinoma results in a more aggressive phenotype. PMID: 22414291
- We have shown that TGF-beta1 expression in gastric tumor tissue with HER2/neu-negative status is of prognostic relevance in gastric cancer. PMID: 22015652
- Force-induced latency-associated peptide conformational changes result in transforming growth factor (TGF)-beta1 release. Mechanical pulling opens the straitjacket structure that keeps TGF-beta1 latent. PMID: 22169532
- genetic polymorphism is associated with both lack of microfilariae and differential microfilarial loads in the blood of persons infected with lymphatic filariasis PMID: 21843572
- a spliced variant form of latent transforming growth factor beta binding protein 1, LTBPD41 is highly expressed in advanced atherosclerotic lesions PMID: 21161366
- Study indicates marked differences in the expression pattern of LTBP1 mRNA and protein in early lesions compared with advanced lesions. PMID: 21071877
- large latent TGFbeta complex (LLC), which contains latent TGFbeta-binding protein 1 (LTBP-1), is directly dependent on the pericellular assembly of fibrillin microfibrils, which interact with fibronectin during higher-order fibrillogenesis. PMID: 20699357
- A strong negative correlation between LTBP-1 and P-Smad2 immunoreactivity was found, implying that LTBP-1 is not likely to contribute directly to the increased levels of TGF-beta activity in malignant mesothelioma. PMID: 21106222
- extracellular HSP90beta is a negative regulator for the activation of latent TGF-beta1 modulating TGF-beta signaling in the extracellular domain. PMID: 20599762
- TGF-beta1 gene -509C/T polymorphism was associated with severe TID. The higher value in serum concentration of TGF-beta1 was also associated with severe TID and the T T genotype/T allele. PMID: 20446778
- TGF-beta(1) augmented Tumor necrosis factor-like weak inducer of apoptosis (TWEAK)-induced production of IL-8 and MCP-1 by retinal pigment epithelial cells. PMID: 19895311
- Latent transforming growth factor beta-binding protein 1 interacts with fibrillin and is a microfibril-associated protein PMID: 12429738
- The current study was carried out to understand hormonal regulation of LTBP-1 expression in normal and SV-40 virus transformed human lung fibroblasts PMID: 14626352
- The LTBP1 protein expressed from a cDNA encoding only the TGF-beta-LAP-binding domain was incapable of supporting alphavbeta6-integrin-mediated activation. PMID: 15564041
- The single nucleotide polymorphisms -202G/C and +20A/C on the LTBP-1L promoter may affect the clinical outcome of ovarian cancer patients, probably via up-regulating protein expression. PMID: 16825507
- LTBP-2 specifically interacts with the amino-terminal region of fibrillin-1 and competes with LTBP-1 PMID: 17293099
- heparan sulfate proteoglycans may play a critical role in regulating TGF-beta availability by controlling the deposition of LTBP1 into the extracellular matrix in association with fibronectin PMID: 17580303
- MT1-MMP-mediated proteolytic processing of ECM-bound LTBP-1 is a mechanism to release latent TGF-beta from the subendothelial matrix. PMID: 18602101
- TGFB1 as an important candidate gene for further biological studies of IgA nephropathy and as a possible target for therapy. Our data also indicate a possibility of a gender effect in the genetic background of IgA nephropathy PMID: 19258388
- Data identify LTBP-1 as an important modulator of TGF-beta activation in glioma cells, which may contribute to the malignant phenotype. PMID: 19431147
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亞細胞定位：Secreted. Secreted, extracellular space, extracellular matrix.
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蛋白家族：LTBP family
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組織特異性：Expressed in the aorta (at protein level). Isoform Long: Expressed in fibroblasts.
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