Recombinant Human Keratin, type II cuticular Hb6 (KRT86)

中文名稱：

人KRT86重組蛋白
貨號：

CSB-YP012581HU
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

人KRT86重組蛋白
貨號：

CSB-EP012581HU
說明書：

MSDS Datasheet
規格：
來源：

E.coli
其他：

中文名稱：

人KRT86重組蛋白
貨號：

CSB-EP012581HU-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

人KRT86重組蛋白
貨號：

CSB-BP012581HU
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：

人KRT86重組蛋白
貨號：

CSB-MP012581HU
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

KRT86
Uniprot No.：

O43790
別名：

Hair keratin K2.11; Hb6; K86; Keratin; Keratin-86; KRT86; KRT86_HUMAN; KRTHB6; MNX; type II cuticular Hb6; Type II hair keratin Hb6; Type-II keratin Kb26
種屬：

Homo sapiens (Human)
蛋白長度：

Full length protein
表達區域：

1-486
氨基酸序列

MTCGSYCGGR AFSCISACGP RPGRCCITAA PYRGISCYRG LTGGFGSHSV CGGFRAGSCG RSFGYRSGGV CGPSPPCITT VSVNESLLTP LNLEIDPNAQ CVKQEEKEQI KSLNSRFAAF IDKVRFLEQQ NKLLETKLQF YQNRECCQSN LEPLFEGYIE TLRREAECVE ADSGRLASEL NHVQEVLEGY KKKYEEEVSL RATAENEFVA LKKDVDCAYL RKSDLEANVE ALIQEIDFLR RLYEEEIRVL QSHISDTSVV VKLDNSRDLN MDCIIAEIKA QYDDIVTRSR AEAESWYRSK CEEMKATVIR HGETLRRTKE EINELNRMIQ RLTAEVENAK CQNSKLEAAV AQSEQQGEAA LSDARCKLAE LEGALQKAKQ DMACLIREYQ EVMNSKLGLD IEIATYRRLL EGEEQRLCEG VGSVNVCVSS SRGGVVCGDL CASTTAPVVS TRVSSVPSNS NVVVGTTNAC APSARVGVCG GSCKRC
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

基因功能參考文獻：
1. Analysis of KRT86 revealed a novel mutation, c.1231G>T;p.Glu411*, in exon 7 in the three affected children and their mother with monilethrix. PMID: 25809918
2. The mutation of extron 7 of KRT86 identified plays a major role in the pathogenesis of this pedigree with monilethrix. PMID: 23981620
3. Congenital monilethrix and hereditary unilateral external auditory canal atresia are co-inherited in a Chinese pedigree with recurrent KRT86 mutation. PMID: 22568869
4. Results idntify a novel mutation of krt86 protein causing monilethrix located in a region other than the helix. PMID: 22670615
5. The KRTHB6 expression uniformly occurred in the midcortex region. PMID: 15797458
6. The results emphasized the key role of hair keratin hHB6 in the pathogenesis of monilethrix and indicated that the common mutation of hHB6 was also a cause of monilethrix in Chinese. PMID: 18393232
7. Mutation E402K of the hHb6 in a Chinese Han family with monilethrix. PMID: 19505862
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相關疾病：

Monilethrix (MNLIX)
蛋白家族：

Intermediate filament family
組織特異性：

Synthesis begins slightly higher in the hair shaft than HB1 and HB3 and continues much farther up, ending in the keratogeneous zone.
數據庫鏈接：

HGNC: 6463

OMIM: 158000

KEGG: hsa:3892

STRING: 9606.ENSP00000452237

UniGene: Hs.278658