Recombinant Human Isthmin-1 (ISM1)

中文名稱：

人ISM1重組蛋白
貨號：

CSB-YP011850HU
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

人ISM1重組蛋白
貨號：

CSB-EP011850HU-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

人ISM1重組蛋白
貨號：

CSB-BP011850HU
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：

人ISM1重組蛋白
貨號：

CSB-MP011850HU
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

ISM1
Uniprot No.：

B1AKI9
別名：

ISM1; C20orf82; ISM; Isthmin-1
種屬：

Homo sapiens (Human)
蛋白長度：

Full Length of Mature Protein
表達區域：

30-464
氨基酸序列

A DGPDAAAGNA SQAQLQNNLN VGSDTTSETS FSLSKEAPRE HLDHQAAHQP FPRPRFRQET GHPSLQRDFP RSFLLDLPNF PDLSKADING QNPNIQVTIE VVDGPDSEAD KDQHPENKPS WSVPSPDWRA WWQRSLSLAR ANSGDQDYKY DSTSDDSNFL NPPRGWDHTA PGHRTFETKD QPEYDSTDGE GDWSLWSVCS VTCGNGNQKR TRSCGYACTA TESRTCDRPN CPGIEDTFRT AATEVSLLAG SEEFNATKLF EVDTDSCERW MSCKSEFLKK YMHKVMNDLP SCPCSYPTEV AYSTADIFDR IKRKDFRWKD ASGPKEKLEI YKPTARYCIR SMLSLESTTL AAQHCCYGDN MQLITRGKGA GTPNLISTEF SAELHYKVDV LPWIICKGDW SRYNEARPPN NGQKCTESPS DEDYIKQFQE AREY
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder Warning: in_array() expects parameter 2 to be array, null given in /www/web/cusabio_cn/public_html/caches/caches_template/default/content/show_product_protein.php on line 662
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Acts as an angiogenesis inhibitor.
基因功能參考文獻：
1. Our study demonstrates a successful pipeline from CNV identification of a candidate gene to functional validation in a vertebrate model system, and reveals Isthmin 1 as both a new human clefting locus as well as a key craniofacial patterning gene. PMID: 29162626
2. Given that ISM1 has been reported to have anti-angiogenic properties, these observations suggest that ISM1 is a mediator of lymphocyte effector functions and may participate in both innate and acquired immune responses. PMID: 24956034
3. Isthmin unexpectedly has both a pro-survival and death-promoting effect on endothelial cells depending on its physical state. PMID: 21544092
亞細胞定位：

Secreted.
蛋白家族：

Isthmin family
數據庫鏈接：

HGNC: 16213

OMIM: 615793

KEGG: hsa:140862

STRING: 9606.ENSP00000262487

UniGene: Hs.559353