Recombinant Human Inhibin beta B chain protein (INHBB), partial

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中文名稱：

人INHBB重組蛋白
貨號：

CSB-EP011720HU1
說明書：

MSDS Datasheet
規格：

￥1836
圖片：
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

純度：

Greater than 90% as determined by SDS-PAGE.
基因名：

INHBB
Uniprot No.：

P09529
種屬：

Homo sapiens (Human)
蛋白長度：

Partial
來源：

E.coli
分子量：

16.5 kDa
表達區域：

295-405aa
氨基酸序列

ECDGRTNLCCRQQFFIDFRLIGWNDWIIAPTGYYGNYCEGSCPAYLAGVPGSASSFHTAVVNQYRMRGLNPGTVNSCCIPTKLSTMSMLYFDDEYNIVKRDVPNMIVEECG
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
蛋白標簽：

N-terminal 6xHis-tagged
產品提供形式：

Liquid or Lyophilized powder Warning: in_array() expects parameter 2 to be array, null given in /www/web/cusabio_cn/public_html/caches/caches_template/default/content/show_product_protein.php on line 662
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
緩沖液：

If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

3-7 business days
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet & COA：

Please contact us to get it.

產品評價

靶點詳情

功能：

Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins.
基因功能參考文獻：
1. Results found that INHBB expression was reduced in nasopharyngeal carcinoma (NPC) tissues, and associated with lymph node metastasis. Further data revealed that INHBB could suppress anoikis resistance and migration of NPC cells by the TGF-beta signaling pathway, decrease p53 overexpression, and could serve as a potential biomarker for NPC metastasis and prognosis . PMID: 30151927
2. Presence of varicocele was associated with lower serum inhibin B. PMID: 27423503
3. Elevated activin B levels together with normal activin A levels identified patients with the diagnostic symptoms of chronic fatigue syndrome/myalgic encephalomyelitis. PMID: 28302133
4. Results identified Inhbb as one factor mediating the proliferative effect of Pdx-1 on islet cells. PMID: 27620967
5. Low activin B level is associated with tubal ectopic pregnancy. PMID: 26968108
6. Pregnant Han Chinese women carrying the rs7579169 CC genotype and G-G-C haplotype are significantly more likely to develop pre-eclampsia, especially late-onset and multiparous cases. PMID: 26313529
7. We report here an original observation that activin-B is upregulated in the human idiopathic pulmonary fibrosis lung. PMID: 25361680
8. reduction of RhoA signaling by Activin B together with persistent Rac1 activity is a prerequisite for inducing an invasive phenotype in clear cell renal cell carcinoma. PMID: 25343250
9. inhibin B and anti-Mullerian hormone serum concentrations did not provide an additional diagnostic tool for male infertility PMID: 25581422
10. inhibin B levels, but not FSH, are increased in primary hypothyroidism, which is consistent with a hypogonadotrophic hypogonadal state affecting the reproductive segment of the gonadotrophic axis PMID: 23692058
11. There are significant differences in serum inhibin B levels in patients with diminished ovarian reserve before and after supplementation with dehydroepiandrosterone (DHEA). PMID: 23664458
12. Inhibin B production was decreased following recombinant human chorionic gonadotropin administration in both control and polycystic ovary syndrome women. PMID: 24188875
13. Inhibin B was measured in plasma samples obtained from 34 healthy male subjects selected on criteria typical for a phase I clinical trial across a wide age range. PMID: 23349064
14. Data indicate that neither serum inhibin B nor follicle-stimulating hormone (FSH) is a suitable surrogate for determination of sperm concentration in a semen sample. PMID: 23423746
15. The signaling pathway responsible for hepcidin up-regulation in the inflammatory context is still not understood completely. Activin B has an unexpected but crucial role in the induction of hepcidin by inflammation. PMID: 22611157
16. A genome-wide association study for preeclampsia in unrelated Australian individuals of Caucasian ancestry was performed to genotype single nucleotide polymorphisms the Inhibin, beta B gene on 2q14.2, in preeclampsia and normal pregnancy controls. PMID: 22432041
17. inhibin-betaB subunit appears not to be a useful prognostic marker regarding endometrioid adenocarcinomas. PMID: 21938679
18. Compared with antimullerian hormone (AMH), stimulated serum inhBB is a more accurate predictor of ovarian response in patients undergoing in vitro fertilization. PMID: 21843890
19. Inhibin B constitutes a reliable marker of Sertoli cell function as well as spermatogenesis, while the clinical significance of anti-Mullerian hormone in men with varicocele remains to be elucidated. PMID: 21285453
20. High inhibin beta B is associated with cervical intraepithelial neoplasia grades 1 and 2 compared to cervix uteri. PMID: 21475087
21. Inhibin B and antimullerian hormone have a role in gonadal function after treatment for medulloblastoma or posterior fossa ependymoma during childhood PMID: 21168856
22. A variant in the fibrillin-3 gene is associated with TGF-beta and inhibin B levels in women with polycystic ovary syndrome. PMID: 20630504
23. The aim of the present study is to investigate the effect of obesity on testicular function by evaluating reproductive hormones, inhibinB, insulin-like 3(INSL3), and leptin, in obese and non-obese adolescents according to pubertal Tanner stages. PMID: 20713036
24. Serum inhibin-b levels decrease nonlinearly during the daytime, and are positively correlated with sperm counts, but the predictive power is best when inhibin-b is low. PMID: 20149358
25. Antral follicle size influences serum inhibin B and FSH levels and alters their expected relationship with the number of antral follicles on day 3 PMID: 19061996
26. Gonads in anorexia nervosa with weight gain have low level of activity. Inhibin B is early marker of gonadal activity, and with weight gain, awakening of the reproductive function is gradual. PMID: 15070953
27. Inhibin B pubertal surge is prominent signal of gonadal maturation in females as well as in males. Significantly higher in boys than in girls. Review. PMID: 15319819
28. The expression of inhibin betaB by Sertoli cells is dependent on the coexistence of spermatogenic activity within these seminiferous tubules and is low in patients with Sertoli cell only syndrome. PMID: 15551748
29. Ovulatory cycles were characterized by higher FSH and lower inhibin B leveels in hypergonadotropic hypogonadism or premature ovarian failure. PMID: 15562017
30. Regular increase of inhibin B(InhB) during puberty. In first phases of gonadal maturation, InhB and FSH correlate positively, while in mid-late stages relationship is inverse. In mid-puberty (G3-G4), serum InhB increases. PMID: 15757857
31. Exposure of the cells of Sertoli to excessive amounts of lead results in inappropriate inhibin B overproduction that may be involved in the impairment of spermatogenesis. PMID: 15910540
32. inhibin B may have a role in male fecundity PMID: 16024538
33. INHBB expression was high in human adipocytes, reduced by weight loss and adipose tissue INHBB mRNA levels correlated to metabolic risk factors. PMID: 16650820
34. A significant down-regulation of inhibin-beta (B) subunit in extravillous trophoblast cells in IUGR syncytiotrophoblast cells was demonstrated. PMID: 16670820
35. Preoperative serum inhibin B concentration could not reliably predict a response to varicocelectomy, but the increase in inhibin B levels after treatment might suggest an improvement in testicular function. PMID: 16728349
36. Follistatin was overexpressed while both activin subunits were downregulated in the majority of rat and human liver tumours PMID: 16935389
37. The present findings showed that treatment with vaginal estroprogestinic decreases serum inhibin A and inhibin B levels, the follicular diameter PMID: 16989826
38. Varicocele sclerotherapy improves inhibin B levels and seminal parameters. PMID: 17376219
39. it is not clear that inhibin B does not seem to play any role in the mechanism of action of laparoscopic ovarian diathermy [letter] PMID: 17525068
40. Granulosa cell production of inhibin B is reduced by pharmacologically induced increase in the intrafollicular androgen levels. PMID: 17628551
41. decreased levels of inhibin b are associated with hot flushes, aches, joint pain, stiffness and depressed mood in the stages of menopausal transition. PMID: 17666595
42. Activin B is a potent inducer of Pdx1 as well as Shh in differentiating embryonic stem cell derived embryoid bodies PMID: 17761145
43. Activin and estrogen crosstalk regulates transcription in human breast cancer cells. PMID: 17914098
44. Used monoclonal antibody to xenopus laevis Inhbb in ELISA for detection of human Inhbb. PMID: 17991484
45. Expression of the beta-B subunit is related to decidualization and can be detected in the circulation as activin B. PMID: 18381568
46. The degree of inhibin B increment during controlled ovarian stimulation provides a way for for predicting ovarian response to ovarian stimulation. PMID: 18555227
47. There was no significant association of (log)inhibin B profiles with age at final menstrual period. PMID: 18593767
48. Functional validation of activins and bone morphogenetic protein 11 as candidate novel muscle mass regulators. PMID: 18927237
49. Serum inhibin B and estradiol concentrations obtained shortly after Gn therapy may offer an accurate and early prediction of ovarian response. PMID: 19198021
50. Inhibin B is more potent than inhibin A in suppressing FSH in vitro and in vivo, and this difference in bioactivity is not explained by its affinity to betaglycan or activin type II receptors. PMID: 19589860
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亞細胞定位：

Secreted.
蛋白家族：

TGF-beta family
數據庫鏈接：

HGNC: 6067

OMIM: 147390

KEGG: hsa:3625

STRING: 9606.ENSP00000295228

UniGene: Hs.1735