Recombinant Human Homeobox protein engrailed-1 (EN1)

中文名稱：

人EN1重組蛋白
貨號：

CSB-YP007659HU
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

人EN1重組蛋白
貨號：

CSB-EP007659HU
說明書：

MSDS Datasheet
規格：
來源：

E.coli
其他：

中文名稱：

人EN1重組蛋白
貨號：

CSB-EP007659HU-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

人EN1重組蛋白
貨號：

CSB-BP007659HU
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：

人EN1重組蛋白
貨號：

CSB-MP007659HU
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

EN1
Uniprot No.：

Q05925
別名：

En 1; EN1; Engrailed 1; Engrailed; Engrailed homeobox 1; Engrailed homolog 1; HME1_HUMAN; Homeobox protein en-1; Homeobox protein engrailed 1; Homeobox protein engrailed-1; Hu-En-1; Mo-en.1; OTTHUMP00000162091
種屬：

Homo sapiens (Human)
蛋白長度：

Full length protein
表達區域：

1-392
氨基酸序列

MEEQQPEPKS QRDSALGAAA AATPGGLSLS LSPGASGSSG SGSDGDSVPV SPQPAPPSPP AAPCLPPLAH HPHLPPHPPP PPPQHLAAPA HQPQPAAQLH RTTNFFIDNI LRPDFGCKKE QPPPQLLVAA AARGGAGGGG RVERDRGQTA AGRDPVHPLG TRAPGAASLL CAPDANCGPP DGSQPAAAGA GASKAGNPAA AAAAAAAAVA AAAAAAAAKP SDTGGGGSGG GAGSPGAQGT KYPEHGNPAI LLMGSANGGP VVKTDSQQPL VWPAWVYCTR YSDRPSSGPR TRKLKKKKNE KEDKRPRTAF TAEQLQRLKA EFQANRYITE QRRQTLAQEL SLNESQIKIW FQNKRAKIKK ATGIKNGLAL HLMAQGLYNH STTTVQDKDE SE
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder Warning: in_array() expects parameter 2 to be array, null given in /www/web/cusabio_cn/public_html/caches/caches_template/default/content/show_product_protein.php on line 662
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

基因功能參考文獻：
1. Engrailed homeobox 1 was expressed specifically in normal eccrine glands and was expressed in most of the tumour cells of sweat gland neoplasms with eccrine gland differentiation. PMID: 29436004
2. our finding suggested that the EN1 rs4144782 might contribute to the susceptibility of knee OA. PMID: 28430581
3. FGFR Inhibitor Ameliorates Hypophosphatemia and Impaired Engrailed-1/Wnt Signaling in FGF2 High Molecular Weight Isoform PMID: 26762209
4. low-frequency non-coding variant near a novel locus, EN1, with an effect on bone mineral density--which was also associated with a decreased risk of fracture PMID: 26367794
5. EN1 is an activator of intrinsic inflammatory pathways associated with prosurvival in basal-like breast cancer. PMID: 24141779
6. The current review describes the role of two such factors, Nurr1 and engrailed, in differentiation, maturation, and in normal physiological functions including acquisition of neurotransmitter identity. PMID: 24685177
7. EN1 is a biologic predictor of poor prognosis in patients with salivary adenoid cystic carcinoma. PMID: 21800291
8. Homeobox protein engrailed-1 protein regulates transcription of the utrophin gene. PMID: 21672318
9. EN1 might be a negative regulatory factor for UTROPHIN. PMID: 21482524
10. The result of this study found a strong association between the EN1 rs1438852 polymorphism and Parkinson's disease. PMID: 19345444
11. En-1 exerts its repressive effect by a mechanism negatively controlling the level of beta-catenin. PMID: 16571670
12. Single nucleotide polymorphisms genotyped in the EN1 gene were associated with schizophrenia symptoms PMID: 18698228
13. Epigenetic suppression along 2q14.2 is common to most colorectal cancers and the presence of a methylated EN1 CpG island in stool DNA might be used as biomarker of neoplastic disease. PMID: 19384295
14. Genetic variation in human engrailed 1 may influence antipsychotic response in schizophrenia. PMID: 18698228
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亞細胞定位：

Nucleus.
蛋白家族：

Engrailed homeobox family
數據庫鏈接：

HGNC: 3342

OMIM: 131290

KEGG: hsa:2019

STRING: 9606.ENSP00000295206

UniGene: Hs.271977