Recombinant Human Homeobox protein Hox-B1 (HOXB1)

中文名稱：

人HOXB1重組蛋白
貨號：

CSB-YP010660HU
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

人HOXB1重組蛋白
貨號：

CSB-EP010660HU
說明書：

MSDS Datasheet
規格：
來源：

E.coli
其他：

中文名稱：

人HOXB1重組蛋白
貨號：

CSB-EP010660HU-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

人HOXB1重組蛋白
貨號：

CSB-BP010660HU
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：

人HOXB1重組蛋白
貨號：

CSB-MP010660HU
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

HOXB1
Uniprot No.：

P14653
別名：

HCFP3; Homeo box 2I; Homeo box B1; Homeobox 2I; Homeobox B1; Homeobox protein Hox B1; Homeobox protein Hox-2I; Homeobox protein Hox-B1; Homeobox protein HoxB1; Homeobox2I; HomeoboxB1; HOX 2; Hox 2.9; HOX 2I; HOX B1; HOX2; Hox2.9; HOX2I; HOXB 1; HOXB1; HOXB1 protein; HXB1_HUMAN; MGC116843; MGC116844; MGC116845
種屬：

Homo sapiens (Human)
蛋白長度：

Full length protein
表達區域：

1-301
氨基酸序列

MDYNRMNSFL EYPLCNRGPS AYSAHSAPTS FPPSSAQAVD SYASEGRYGG GLSSPAFQQN SGYPAQQPPS TLGVPFPSSA PSGYAPAACS PSYGPSQYYP LGQSEGDGGY FHPSSYGAQL GGLSDGYGAG GAGPGPYPPQ HPPYGNEQTA SFAPAYADLL SEDKETPCPS EPNTPTARTF DWMKVKRNPP KTAKVSEPGL GSPSGLRTNF TTRQLTELEK EFHFNKYLSR ARRVEIAATL ELNETQVKIW FQNRRMKQKK REREEGRVPP APPGCPKEAA GDASDQSTCT SPEASPSSVT S
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder Warning: in_array() expects parameter 2 to be array, null given in /www/web/cusabio_cn/public_html/caches/caches_template/default/content/show_product_protein.php on line 662
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Acts on the anterior body structures.
基因功能參考文獻：
1. This is the first disease-associated HOXB1 mutation with a likely loss-of-function effect suggesting that all HOXB1 variants reported so far also have severe impact on activity of this transcriptional regulator PMID: 27144914
2. findings revealed a novel homozygous mutation p.Arg230Trp (c.688C>T) within the HOXB1 gene of three members of a Turkish family with hereditary congenital facial paresis (HCFP3) PMID: 27640920
3. HOXB1 functions as a tumor suppressor, regulated by miR-3175 in glioma. PMID: 26565624
4. The resulting phenotype includes bilateral facial palsy, hearing loss, and strabismus and correlates extensively with the previously reported Hoxb1(-/-) mouse phenotype. PMID: 22770981
5. Hoxb1 Expression Induces Cell Fate Changes in the Trunk Neural Tube. PMID: 21433221
6. analysis of a tethered-hopping model for protein-DNA binding and unbinding based on Sox2-Oct1-Hoxb1 ternary complex simulations PMID: 20371328
7. Data show that inducible Hox genes are selectively sensitive to the inhibition of actin polymerization and that actin polymerization is required for the assembly of a transcription complex on the regulatory region of the Hox genes. PMID: 19477923
8. It is unlikely that HoxB1 plays a significant role in the genetic predisposition to autism. PMID: 11840501
9. UTX directly binds to the HOXB1 locus and is required for its activation PMID: 17713478
10. HoxB1 interacts with Pax6 and enhances its transcriptional activity. This interaction was modeled on a demonstrated interaction between zebrafish Pax6 and human HoxB1. PMID: 11069920
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相關疾病：

Facial paresis, hereditary congenital, 3 (HCFP3)
亞細胞定位：

Nucleus.
蛋白家族：

Antp homeobox family, Labial subfamily
數據庫鏈接：

HGNC: 5111

OMIM: 142968

KEGG: hsa:3211

STRING: 9606.ENSP00000355140

UniGene: Hs.99992