Recombinant Human H/ACA ribonucleoprotein complex subunit 3 (NOP10)

中文名稱：

人NOP10重組蛋白
貨號：

CSB-YP873610HU
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

人NOP10重組蛋白
貨號：

CSB-EP873610HU
說明書：

MSDS Datasheet
規格：
來源：

E.coli
其他：

中文名稱：

人NOP10重組蛋白
貨號：

CSB-EP873610HU-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

人NOP10重組蛋白
貨號：

CSB-BP873610HU
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：

人NOP10重組蛋白
貨號：

CSB-MP873610HU
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

NOP10
Uniprot No.：

Q9NPE3
別名：

DKCB1; H/ACA ribonucleoprotein complex subunit 3; homolog of yeast Nop10p; MGC70651; NOLA3; NOP10; NOP10 ribonucleoprotein homolog (yeast); NOP10_HUMAN; NOP10P; Nucleolar protein 10; Nucleolar protein family A member 3; nucleolar protein family A, member 3 (H/ACA small nucleolar RNPs); snoRNP protein NOP10
種屬：

Homo sapiens (Human)
蛋白長度：

full length protein
表達區域：

1-64
氨基酸序列

MFLQYYLNEQ GDRVYTLKKF DPMGQQTCSA HPARFSPDDK YSRHRITIKK RFKVLMTQQP RPVL
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Required for ribosome biogenesis and telomere maintenance. Part of the H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Each rRNA can contain up to 100 pseudouridine ('psi') residues, which may serve to stabilize the conformation of rRNAs. May also be required for correct processing or intranuclear trafficking of TERC, the RNA component of the telomerase reverse transcriptase (TERT) holoenzyme.
基因功能參考文獻：
1. Indian aplastic anemia patients did not have NOP10 mutations. PMID: 25906515
2. Effects of dyskeratosis congenita mutations in NOP10 on assembly of H/ACA pre-RNPs PMID: 20008900
3. NOP10 has a role in the telomerase complex and telomere maintenance, and in autosomal recessive dyskeratosis congenita PMID: 17507419
相關疾病：

Dyskeratosis congenita, autosomal recessive, 1 (DKCB1)
亞細胞定位：

Nucleus, nucleolus. Nucleus, Cajal body. Note=Also localized to Cajal bodies (coiled bodies).
蛋白家族：

NOP10 family
數據庫鏈接：

HGNC: 14378

OMIM: 224230

KEGG: hsa:55505

STRING: 9606.ENSP00000332198

UniGene: Hs.14317