Recombinant Human GDNF family receptor alpha-3 (GFRA3)

中文名稱：

人GFRA3重組蛋白
貨號：

CSB-YP009381HU
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

人GFRA3重組蛋白
貨號：

CSB-EP009381HU
說明書：

MSDS Datasheet
規格：
來源：

E.coli
其他：

中文名稱：

人GFRA3重組蛋白
貨號：

CSB-EP009381HU-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

人GFRA3重組蛋白
貨號：

CSB-BP009381HU
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：

人GFRA3重組蛋白
貨號：

CSB-MP009381HU
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

GFRA3
Uniprot No.：

O60609
別名：

GDNF family receptor alpha 3; GDNF family receptor alpha-3; GDNF receptor alpha-3; GDNFR-alpha-3; GDNFR3; GFR-alpha-3; GFRA3; GFRA3_HUMAN; Glial cell line derived neurotrophic factor receptor alpha 3 ; GPI linked receptor; OTTHUMP00000159486; OTTHUMP00000224020
種屬：

Homo sapiens (Human)
蛋白長度：

Full Length of Mature Protein
表達區域：

32-374
氨基酸序列

DPLPTESRL MNSCLQARRK CQADPTCSAA YHHLDSCTSS ISTPLPSEEP SVPADCLEAA QQLRNSSLIG CMCHRRMKNQ VACLDIYWTV HRARSLGNYE LDVSPYEDTV TSKPWKMNLS KLNMLKPDSD LCLKFAMLCT LNDKCDRLRK AYGEACSGPH CQRHVCLRQL LTFFEKAAEP HAQGLLLCPC APNDRGCGER RRNTIAPNCA LPPVAPNCLE LRRLCFSDPL CRSRLVDFQT HCHPMDILGT CATEQSRCLR AYLGLIGTAM TPNFVSNVNT SVALSCTCRG SGNLQEECEM LEGFFSHNPC LTEAIAAKMR FHSQLFSQDW PHPTFAVMAH QNEN
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder Warning: in_array() expects parameter 2 to be array, null given in /www/web/cusabio_cn/public_html/caches/caches_template/default/content/show_product_protein.php on line 662
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Receptor for the glial cell line-derived neurotrophic factor, ARTN (artemin). Mediates the artemin-induced autophosphorylation and activation of the RET receptor tyrosine kinase.
基因功能參考文獻：
1. increased GFRalpha3 expression is significantly correlated with poor prognosis of patients with urothelial carcinoma PMID: 28651425
2. Mir-34a directly regulates GFRA3 via its coding region.GFRA3 is crucial for breast cancer growth. PMID: 28356515
3. The GFRA3 promoter region showed marked hypermethylation in almost all tumors, and its correlation with survival and other clinicopathological parameters may have important prognostic significance. PMID: 26984265
4. The lack of expression of the RET/GFRA system could be related to the cell mislocation and deregulated growth of craniopharyngiomas. PMID: 22031517
5. Artemin and GFRalpha3 expressions may play an important role in perineural invasion of pancreatic carcinoma. PMID: 19304517
6. 1.92 A crystal structure of the complex formed between ARTN and its receptor GFRalpha3 was reported. PMID: 16765900
7. In the human digestive and reproductive systems, a subset of epithelial cells exhibited GFRalpha3- and RET-like staining, suggesting co-localization. PMID: 16773224
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亞細胞定位：

Cell membrane; Lipid-anchor, GPI-anchor.
蛋白家族：

GDNFR family
組織特異性：

Widely expressed in adult and fetus which exhibit a similar pattern. Essentially not expressed in the central nervous system, but highly expressed in several sensory and sympathetic ganglia of the peripheral nervous system. Moderate expression in many non
數據庫鏈接：

HGNC: 4245

OMIM: 605710

KEGG: hsa:2676

STRING: 9606.ENSP00000274721

UniGene: Hs.58042