Recombinant Human Factor in the germline alpha (FIGLA)

中文名稱：

人FIGLA重組蛋白
貨號：

CSB-YP750909HU
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

人FIGLA重組蛋白
貨號：

CSB-EP750909HU
說明書：

MSDS Datasheet
規格：
來源：

E.coli
其他：

中文名稱：

人FIGLA重組蛋白
貨號：

CSB-EP750909HU-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

人FIGLA重組蛋白
貨號：

CSB-BP750909HU
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：

人FIGLA重組蛋白
貨號：

CSB-MP750909HU
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

FIGLA
Uniprot No.：

Q6QHK4
別名：

FIGLA; BHLHC8Factor in the germline alpha; FIGalpha; Class C basic helix-loop-helix protein 8; bHLHc8; Folliculogenesis-specific basic helix-loop-helix protein; Transcription factor FIGa
種屬：

Homo sapiens (Human)
蛋白長度：

full length protein
表達區域：

1-219
氨基酸序列

MDPAPGVLDP RAAPPALLGT PQAEVLEDVL REQFGPLPQL AAVCRLKRLP SGGYSSTENL QLVLERRRVA NAKERERIKN LNRGFARLKA LVPFLPQSRK PSKVDILKGA TEYIQVLSDL LEGAKDSKKQ DPDEQSYSNN SSESHTSSAR QLSRNITQHI SCAFGLKNEE EGPWADGGSG EPAHACRHSV MSTTEIISPT RSLDRFPEVE LLSHRLPQV
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Germline specific transcription factor implicated in postnatal oocyte-specific gene expression. Plays a key regulatory role in the expression of multiple oocyte-specific genes, including those that initiate folliculogenesis and those that encode the zona pellucida (ZP1, ZP2 and ZP3) required for fertilization and early embryonic survival. Essential for oocytes to survive and form primordial follicles. The persistence of FIGLA in adult females suggests that it may regulate additional pathways that are essential for normal ovarian development. Binds to the E-box (5'-CANNTG-3') of the ZPs (ZP1, ZP2, ZP3) promoters.
基因功能參考文獻：
1. Biallelic mutations in FIGLA may be the cause of premature ovarian insufficiency (POI) . This study will aid researchers and clinicians in genetic counseling of POI and provides new insights into understanding the mode of genetic inheritance of FIGLA mutations in POI pathology. PMID: 29914564
2. study identified an association between FIGLA gene variants and the occurrence of premature ovarian failure(POF) in the Indian population; findings suggest that the c.427G->C and c.557C->T alleles lead to an increased risk of POF in Indian women PMID: 25314148
3. Expression of mRNA observed in ovarian follicles, mature oocytes, and less frequently in preimplantation embryos. PMID: 12468641
4. These results suggest that FIGLA is involved in continued oocyte survival as primordial follicles form in the human as in the rodent ovary. PMID: 15044608
5. the p.140 delN mutation disrupted FIGLA binding to the TCF3 helix-loop-helix (HLH) domain. Our findings show that a subset of Chinese women with sporadic, premature ovarian failure harbor mutations in FIGLA. PMID: 18499083
6. may have a role in the development of primordial follicle before zona pellucida formation PMID: 18502569
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相關疾病：

Premature ovarian failure 6 (POF6)
亞細胞定位：

Nucleus.
組織特異性：

Germ cells. Expressed in the fetal ovary, but not by a range of other tissues. Expression increases across mid-gestation, rising some 40-fold by the time of primordial follicle formation.
數據庫鏈接：

HGNC: 24669

OMIM: 608697

KEGG: hsa:344018

STRING: 9606.ENSP00000333097

UniGene: Hs.407636